Screening of non-alkaloid acetylcholinesterase inhibitors from extracts and essential oils of Anthriscus nemorosa (M.Bieb.) Spreng. (Apiaceae)

WOS: 000488195200034This screening of biologically active compounds, cholinesterase inhibition and antioxidant potentials of extracts and essential oils from different plant parts such as fruits, aerial parts, roots and flowers of Anthriscus nemorosa was performed. GC analytical results of essential oil compositions have been detailed described. It was found that EtOAc fraction of root and root essential oil had the highest total phenolics content and antioxidant activity (DPPH test). the essential oil of roots showed the highest butyrylcholinesterase inhibition (88.51%). alpha-Pinene as the major component of root essential oil also indicated strong butyrylcholinesterase inhibitory activity (72.09%) and antioxidant effect. the GC-FID and GC-MS analysis assessed that major monoterpene of roots and aerial parts were alpha-pinene (25.5.%), myristicin (10.4%), p-cymene (8.2%), limonene (6.0%) and fatty alcohol 1-heptadecanol (7.5%). the root and aerial part canals revealed the smaller number of secretory canals which contains mainly monoterpene and oxygenated monoterpenes. the secretory canals of fruits and flowers were characterised by the largest shape and contain a high amount of sesquiterpene hydrocarbon bicyclogermacrene. the high content of sesquiterpene spathulenol (49.6%) was estimated in the extracts of the aerial part. These presented findings represented that the roots essential oil of A. nemorosa may be a novel alternative source of natural antioxidant and anticholinesterase. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.Research Fund of the Ataturk UniversityThis work was supported by Research Fund of the Ataturk University

Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases

Due to its vast therapeutic potential, the plant-derived polyphenol curcumin is utilized in an ever-growing number of health-related applications. Here, we report the extraction methodologies, therapeutic properties, advantages and disadvantages linked to curcumin employment, and the new strategies addressed to improve its effectiveness by employing advanced nanocarriers. The emerging nanotechnology applications used to enhance CUR bioavailability and its targeted delivery in specific pathological conditions are collected and discussed. In particular, new aspects concerning the main strategic nanocarriers employed for treating inflammation and oxidative stress-related diseases are reported and discussed, with specific emphasis on those topically employed in conditions such as wounds, arthritis, or psoriasis and others used in pathologies such as bowel (colitis), neurodegenerative (Alzheimer's or dementia), cardiovascular (atherosclerosis), and lung (asthma and chronic obstructive pulmonary disease) diseases. A brief overview of the relevant clinical trials is also included. We believe the review can provide the readers with an overview of the nanostrategies currently employed to improve CUR therapeutic applications in the highlighted pathological conditions.N.C.-M. acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017). This work was supported by the CONICYT PIA/APOYO CCTE AFB170007, Seed #2001050151 and Collaborative #2101050160—University of Sharjah and Fondo di Ateneo per la Ricerca 2020, University of Sassari

Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms

Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. On the evidence of varied pharmacological properties, the present work presents an overall review of the derivation, availability, and biological capacities of coumarins with further consideration of the essential mode of their therapeutic actions. In conclusion, a wide variety of coumarins are available, and their pharmacological activities are of current interest thanks to their synthetic accessibility and riches in medicinal plants. Coumarins perform the valuable function as therapeutic agents in a range of medical fields

Wheat (Triticum aestivum l.) production under drought and heat stress – adverse effects, mechanisms and mitigation: A review

Heat and drought stresses are the most important abiotic factors that reduce crops productivity by affecting various physiological and biochemical processes. Thus, selecting cultivars with better drought or heat stress tolerance or breeding for stress tolerance will be helpful in enhancing crop productivity under harsh environments. This review elaborates the physiological basis of high temperature and drought stress tolerance in wheat which can be used as selection criteria in wheat breeding program. In addition, some agronomic selection criteria which are valid and useful in selecting stress tolerant wheat species and cultivars. The review also discussed the valid usage of stress tolerance indices (such as mean productivity (MP), geometric mean productivity (GMP), yield index (YI), yield stability index (YSI), relative productivity (RP%), stress susceptibility index (SSI), and the tolerance index (TOL)) to scan the genotypes against drought and heat stress. Beside these, exogenous application of stress signaling compounds, osmolytes, or certain inorganic salts play a vital role for alleviating adverse effects of abiotic stresses for sustainable wheat production. In addition, applications for soil amendments will also helpful in increasing wheat crop productivity under stressful conditions. All these strategies may be helpful to meet the food demands of the increasing population.Fil: El Sabagh, A.. University of Kafrelsheikh; EgiptoFil: Hossain, A.. Bangladesh Agricultural Research Institute; BangladeshFil: Barutçular, C.. University of Çukurova; TurquíaFil: Islam, Mohammad Sirajul. Hajee Mohammad Danesh Science and Technology University; BangladeshFil: Awan, S. I.. University of the Poonch; PakistánFil: Galal, A.. University of Kafrelsheikh; EgiptoFil: Iqbal, M. A.. University of the Poonch; PakistánFil: Sytar, O.. Slovak University of Agriculture; EslovaquiaFil: Yildirim, M.. Dicle University; TurquíaFil: Meena, R. S.. Inistitute of Agricultural Sciences; IndiaFil: Fahad, S.. The University of Swabi; PakistánFil: Najeeb, U.. The University of Queensland; AustraliaFil: Konuskan, O.. Mustafa Kemal University; TurquíaFil: Habib, R. A.. Bahauddin Zakariya University; PakistánFil: Llanes, Analia Susana. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones Agrobiotecnológicas - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Agrobiotecnológicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; ArgentinaFil: Hussain, S.. University of Agriculture; PakistánFil: Farooq, M.. Sultan Qaboos University; OmánFil: Hasanuzzaman, M.. Sher-e-Bangla Agricultural University; BangladeshFil: Abdelaal, K. H.. Kafrelsheikh University; EgiptoFil: Hafez, Y.. Kafrelsheikh University; EgiptoFil: Cig, F.. Siirt University; TurquíaFil: Saneoka, H.. Hiroshima University; Japó

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.CR would like to acknowledge the UID/EQU/00511/2020 Project—Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE), financed by national funds through FCT/MCTES (PIDDAC). NC-M acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017). Some of the components of the illustrations are taken from freepik and flaticon

Статус поняття «словниковий маркетинг» у сучасній лексикографії.

У дослідженні проаналізовано погляди дослідників на маркетинг. Розглянуто статус поняття «словниковий маркетинг» у сучасній лексикографії. Визначено мету й основні етапи словникового маркетингу. Специфіка досліджуваної теми передбачає застосування аналітичного методу

Plasticity of photosynthetic processes and the accumulation of secondary metabolites in plants in response to monochromatic light environments: A review

Light spectra significantly influence plant metabolism, growth and development. Here, we review the effects of monochromatic blue, red and green light compared to those of multispectral light sources on the morpho-anatomical, photosynthetic and molecular traits of herbaceous plants. Emphasis is given to the effect of light spectra on the accumulation of secondary metabolites, which are important bioactive phytochemicals that determine the nutritional quality of vegetables. Overall, blue light may promote the accumulation of phenylpropanoid-based compounds without substantially affecting plant morpho-anatomical traits compared to the effects of white light. Red light, conversely, strongly alters plant morphology and physiology compared to that under white light without showing a consistent positive effect on secondary metabolism. Due to species-specific effects and the small shifts in the spectral band within the same color that can substantially affect plant growth and metabolism, it is conceivable that monochromatic light significantly affects not only plant photosynthetic performance but also the “quality” of plants by modulating the biosynthesis of photoprotective compounds