Fachspezifische Suche nach elektronischen Zeitschriften : Ein webliographischer Streifzug am Beispiel der Informationswissenschaft

This paper presents and evaluates existing options for searching electronic journals in library and information science. It focuses on web-based collections of links and references (webliographies), and on e-journals available on the web that are listed by such sources. Both multidisciplinary and specialised listings from German- and English-speaking countries are reviewed. The author's survey reveals a surprisingly large number of web-based e-journals listed by these sources. However, the latter seem to operate without any co-ordination in the way they register and list the journals

[Review of:] Vanda Broughton, Essential thesaurus construction. London: Facet Publishing, 2006. - v, 296 S., ISBN 1-85604-565-X

Book review of Vanda Broughton, Essential thesaurus construction. London: Facet Publishing, 2006. - v+296p., ISBN 1-85604-565-X. This book is for anyone concerned with the job of document analysis, description, and organization for retrieval

Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol

Cholesterol was linked to 2'-O-methyl-oligoribonucleotides (2'-OMe-RNA) via a disulfide bond by reacting the 3'-(pyridyldithio)-modified 2'-OMe-RNA with thiocholesterol in dichloromethane-methanol solution. This ligation reaction was made possible by a novel strategy in which the highly charged oligonucleotide was rendered soluble in nonaqueous solvent through conversion to a lipophilic amidinium salt. The biodegradable lipophilic modification of 2'-OMe-RNA resulted in a large increase in incorporation of such oligonucleotides into liposomes prepared by reversephase evaporation. Furthermore, association of these modified oligonucleotides with cultured TIB 73 cells was 100-fold higher than that seen with unmodified 2'-OMe-RNA in serum-free medium and about 10 to 30-fold higher in the presence of 10% calf serum. During incubation with cells, release of the internalized oligonucleotide from the thiocholesteryl moiety can be demonstrated