Oculocutaneous albinism and reduced bone density in two sibs: a new autosomal recessive syndrome?

A sister and brother, with oculocutaneous albinism and reduced bone density are described. Autosomal recesive inheritance is possible. This association has not been previously described. Clin dysmorphol 9: 295-296 (C) 2000 Lippincott Williams & Wilkins

Seizures in a boy with subacute sclerosing panencephalitis during high-dose intrathecal interferon-alpha therapy

A 27-month-old boy was admitted with speech abnormality, inability to walk, and involuntary movements. He was diagnosed with subacute sclerosing panencephalitis based on clinical and laboratory findings. Inosiplex (100 mg/kg/ day orally) plus intrathecal interferon-alpha (3 million units/dose twice per week) in a standard regime were given. After four doses of interferon it was prescribed as 6 million units/dose/week because he had been admitted from a remote district. One day after giving the second dose of 6 million units of interferon, two generalized tonic-elonic seizures that occurred within an hour, associated with high fever, which lasted approximately 5 minutes were observed. An antiepileptic agent was not administered because electroencephologram results did not indicate epileptic discharges. After this condition we returned to the first treatment protocol of interferon (3 million units/dose twice per week). At the current time, he is in the fifth month of follow-up and remains convulsion-free. To the best of our knowledge, seizures as a result of high-dose intratechal interferon in subacute sclerosing panencephalitis has not been reported in the literature. Our patient demonstrated that it is reasonable to avoid the use of high-dose intrathecal interferon-alpha in childhood. (C) 2002 by Elsevier Science Inc. All rights reserved

Computing 3-dimensional groups : crossed squares and cat2-groups

The category XSq of crossed squares is equivalent to the category Cat2 of cat2-groups. Functions for computing with these structures have been developed in the package XMod written using the GAP computational discrete algebra programming language. This paper contains a table listing the numbers ι2G of isomorphism classes of cat2-groups on groups G of order at most 30 – a total of 1007 cat2- groups. Secondly, it contains general formulae for ι2G in a number of special cases