PROSES PENGELOLAAN HASIL HUTAN BUKAN KAYU (HHBK) GULA AREN DI DESA ETI KECAMATAN SERAM BARAT KABUPATEN SERAM BAGIAN BARAT

Hasil Hutan Bukan Kayu (HHBK) berperan penting dalam ekosistem hutan dan kehidupan manusia. HHBK telah digunakan oleh masyarakat sekitar hutan secara langsung maupun tidak langsung. HHBK memiliki nilai ekonomi yang penting dan dapat memenuhi kebutuhan masyarakat dalam hal pangan, papan, dan keperluan ritual. Beberapa jenis HHBK yang telah dimanfaatkan dan dikomersialkan antara lain cendana, gaharu, sagu, rotan, aren, sukun, bambu, sutera alam, jernang, kemenyan, kayu putih, aneka tanaman obat, minyak atsiri, dan madu. Salah satu HHBK yang memiliki nilai ekonomi tinggi dan menjadi sumber pendapatan masyarakat pedesaan adalah Arenga pinnata atau yang dikenal sebagai enau atau aren. Aren (Arenga pinnata Merr.) adalah pohon serbaguna yang telah lama dikenal menghasilkan bahan-bahan industri. Tumbuhan aren menghasilkan buah, nira, dan pati atau tepung di dalam batangnya. Semua hasil produksi aren ini memiliki nilai ekonomi dan dapat dimanfaatkan, termasuk akar, batang, buah, tandan bunga, dan ijuk. Di Maluku, banyak tumbuh pohon aren, dan masyarakat di pedesaan memanfaatkannya untuk konsumsi dan produksi. Salah satu bagian aren yang digunakan adalah tangkai bunganya yang menghasilkan air nira atau sageru. Air nira ini dapat diolah menjadi sageru, cuka, gula aren, dan sopi, yang menjadi sumber pendapatan masyarakat. Di desa Eti, kecamatan Seram Barat, kabupaten Seram Bagian Barat, mayoritas penduduknya adalah petani. Salah satu komoditas utama yang dimanfaatkan adalah air nira dari pohon aren untuk dijadikan sopi, gula aren, dan adonan kue. Meskipun gula aren juga memiliki nilai ekonomi, produksinya masih terbatas di kalangan masyarakat. Oleh karena itu, pada saat menjelang hari-hari besar seperti Natal dan Paskah, baru diproduksi dalam jumlah yang lebih banyak. rogram KKN Tematik Individu memiliki bertujuan untuk mengembangkan ketrampilan dan pengetahuan mahasiswa dalam bidang yang ditekuni, dan juga memberikan pengalaman belajar yang nyata kepada mahasiswa. Melalui program ini, mahasiswa dapat belajar dan bekerja dalam masyarakat untuk menerapkan dan mengembangkan ilmu dan pengetahuan di luar kampus. Program ini juga dapat meningkatkan keterampilan mahasiswa dalam memecahkan masalah yang ada di masyarakat serta memberikan informasi terkait pengelolaan HHBK Gula Aren dalam upaya meningkatkan perekonomian masyarakat desa Eti

Effects of graft pretensioning in anterior cruciate ligament reconstruction

Purpose Graft pretensioning is used in anterior cruciate ligament (ACL) reconstruction to prevent secondary slackening. Its effects on collagen fibrillar ultrastructure are not known. In this study, we hypothesized that graft pretensioning in ACL reconstruction creates ultrastructural changes detectable in scanning electron microscopy (SEM). Methods A prospective comparative study was carried out on 38 ACL reconstructions using a 4-strand semitendinosus graft. Samples were harvested intra-operatively before and after pretensioning for 30 s, 2 or 5 min. The images produced in SEM were analyzed using an original semi-quantitative «CIP» score taking into account collagen cohesion, integrity, and parallelism. Intra- and inter-tester reliability for the CIP score were tested. Results The CIP scores decreased by 3.5 (1.6) points after pretensioning (P < 0.05). Significant differences were found in the 5, 2 min and 30 s subgroups for the global CIP score. Relative decrease (Delta CIP) was significantly higher in the 2 and 5 min subgroups after pretensioning in comparison with the 30 s subgroups. Intra- and inter-tester reliability for the CIP score were 0.85 and 0.92 (P < 0.05). Conclusion Pretensioning ACL grafts resulted in alteration of the collagen fibrillar ultrastructure, detectable using SEM. These results confirm the existence of collagen ultrastructural changes after pretensioning that may be related to its duration. Level of evidence Prospective comparative study, Level II

Barriers to self-care among diabetes patients: A qualitative study

Diabetes mellitus (DM) is a significant global health issue, with its prevalence continuing to rise in Indonesia. Self-care is a key component in managing DM, yet many patients face various obstacles in its implementation. This study aims to deeply explore the challenges faced by individuals with type 2 diabetes in managing their condition independently. Using a descriptive qualitative approach, the study analyzes the experiences of seven diabetes patients receiving care at Royal Prima Hospital. The social ecological model serves as the analytical framework to identify factors influencing self-care behavior, including individual internal factors, interpersonal relationships, healthcare systems, and the social environment. Data was collected through in-depth interviews and analyzed using thematic content analysis. The findings reveal several barriers to effective self-care in diabetes management. Firstly, at the individual level, a lack of knowledge, limited resources, non-adherence to medication, and financial constraints were major obstacles. Secondly, insufficient social support and misinformation about alternative treatments also influenced patient behavior. Thirdly, at the healthcare service level, long waiting times and inadequate social support were identified as challenges. Lastly, limited accessibility due to transportation issues and community resource constraints further hindered self-care. Patients require comprehensive education, easy access to medical tools, and psychological support to manage their condition effectively. Families and communities must be equipped with accurate knowledge about diabetes and trained to support patients. Healthcare providers should improve service quality by adopting a holistic approach and collaborating with communities to ensure optimal care. With collective efforts, it is hoped that the quality of life for diabetes patients can improve, and complications resulting from the disease can be prevented

From writing to screen: Goliyon Ki Raasleela Ram-Leela by Sanjay Leela Bhansali

openIl presente lavoro di tesi si propone di esplorare il cinema indiano attraverso l'analisi approfondita del film Goliyon Ki Raasleela Ram-Leela (2013), diretto da Sanjay Leela Bhansali. L'introduzione offrirà una panoramica di Bollywood e spiegherà le motivazioni che mi hanno portato a scegliere questo percorso. La tesi sarà suddivisa in due capitoli principali. Il primo capitolo si concentrerà sulla scrittura e sul adattamento di Romeo e Giulietta , mentre il secondo capitolo analizzerà il film, esaminandone gli aspetti tecnici, i temi, la regia, la colonna sonora e la rappresentazione dei personaggi. Questa tesi mira a fornire una comprensione approfondita dell'interazione tra testo teatrale e mezzo cinematografico, evidenziando come Romeo e Giulietta continui a essere una fonte di ispirazione per il cinema in tutto il mondo.This thesis aims to explore Indian cinema through an in-depth analysis of the film Goliyon Ki Raasleela Ram-Leela (2013), directed by Sanjay Leela Bhansali. The introduction will provide an overview of Bollywood and explain why I chose this topic. The thesis will be divided into two main chapters. The first chapter will focus on the writing and adaptation of Romeo and Juliet, in contrast, the second chapter will analyze the film, examining its technical aspects, themes, direction, soundtrack, and character portrayal. This thesis aims to offer a comprehensive understanding of the interaction between theatrical text and cinematic medium, highlighting how Romeo and Juliet continue to be a source of inspiration for cinema worldwide

Drugs targeting the bone microenvironment: new therapeutic tools in Ewing's sarcoma?

Introduction: Ewing's sarcoma (ES) is the second most frequent malignant primary bone tumour in children, adolescents and young adults. The overall survival is 60 – 70% at 5 years but still very poor for patients with metastases, disease relapse or for those not responding to chemotherapy. For these high risk patients, new therapeutic approaches are needed beyond conventional therapies (chemotherapy, surgery and radiation) such as targeted therapies. Areas covered: Transcriptomic and genomic analyses in ES have revealed alterations in genes that control signalling pathways involved in many other cancer types. To set up more specific approaches, it is reasonable to think that the particular microenvironment of these bone tumours is essential for their initiation and progression, including in ES. To support this hypothesis, preclinical studies using drugs targeting bone cells (bisphosphonate zoledronate, anti-receptor activator of NF-κB ligand strategies) showed promising results in animal models. This review will discuss the new targeted therapeutic options in ES, focusing more particularly on the ones modulating the bone microenvironment. Expert opinion: Targeting the microenvironment represents a new option for patients with ES. The proof-of-concept has been demonstrated in preclinical studies using relevant animal models, especially for zoledronate, which induced a strong inhibition of tumour progression in an orthotopic bone model

Hubungan Status Gizi dan Infeksi Terhadap Kejadian Ketuban Pecah Dini pada Ibu Hamil di RSUD Prof. Dr. H. M. Chatib Quzwain Sarolangun Tahun 2022

Ketuban Pecah Dini (KPD) merupakan kelainan ketuban pada kehamilan dimana normalnya ketuban pecah dan keluar saat terjadinya kontraksi rahim menjelang persalinan, namun ketuban pecah sebelum saat persalinan tiba. Menurut WHO 2021 Angka Kematian Ibu (AKI) tertinggi secara global sebanyak 295.000, dengan resiko kematian ibu sebesar 211 kematian ibu per 100.000 kelahiran hidup. Menurut profil Kesehatan Indonesia tahun 2021 yang dihimpun dari pencatatan program kesehatan keluarga di Kementerian Kesehatan jumlah AKI tertinggi meningkat setiap tahunnya. Pada tahun 2021 angka kematian di Indonesia sebesar 7.389. Terjadi peningkatan AKI dibandingkan tahun 2020 sebanyak 4.627 kematian ibu. Tujuan dari penelitian ini untuk mengetahui apa saja faktor - Faktor yang berhubungan dengan kejadian ketuban pecah dini di RSUD Chatib Quzwain Sarolangun Tahun 2022. Penelitian ini menggunakan metode penelitian Deskriptif Analitik.  Pendekatan penelitian menggunakan metode cross sectional. Populasi dari KPD ini yaitu sebanyak 372 ibu hamil yang terdata sebagai KPD selama 1 tahun terakhir yaitu tahun 2022. Sampel pada penelitian ini terdiri dari 79 orang ibu hamil dengan KPD. Data diperoleh dari data skunder rekam medis dan buku register pasien KPD dan di analisis menggunakan uji chi – square. Berdasarkan tabel Uji Statistik dapat diketahui bahwa dari uji chi – square diperoleh hasil  karakteristik responden yaitu umur (P – value = 0,10) lebih besar dari sig α (0,05),  dan karakteristik pada paritas (P – value = 0,000) lebih kecil  dari sig α (0,05). Selanjutnya status gizi (P – value = 0,450) lebih besar dari sig α (0,05) dan Selanjutnya infeksi  (P – value = 0,001.) lebih kecil dari sig α (0,05). Sehingga disimpulkan bahwa terdapat hubungan pada ksarkteristik paritas dan variabel Infeksi  dengan kejadian Ketuban Pecah Dini pada Ibu hamil. Diharapkan bagi tenaga kesehatan untuk mengevaluasi kembali tentang hubungan status gizi dan infeksi terhadap kejadian Ketuban Pecah Dini Pada Ibu Hamil di RSUD Prof Dr. H.M. Chatib Quzwain Sarolangun Tahun 2022

Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma

Ewing sarcoma is the second most common pediatric bone tumor, with three cases per million worldwide. In clinical terms, Ewing sarcoma is an aggressive, rapidly fatal malignancy that mainly develops not only in osseous sites (85%) but also in extra-skeletal soft tissue. It spreads naturally to the lungs, bones, and bone marrow with poor prognosis in the two latter cases. Bone lesions from primary or secondary (metastases) tumors are characterized by extensive bone remodeling, more often due to osteolysis. Osteoclast activation and subsequent bone resorption are responsible for the clinical features of bone tumors, including pain, vertebral collapse, and spinal cord compression. Based on the "vicious cycle" concept of tumor cells and bone resorbing cells, drugs, which target osteoclasts, may be promising agents as adjuvant setting for treating bone tumors, including Ewing sarcoma. There is also increasing evidence that cellular and molecular protagonists present in the bone microenvironment play a part in establishing a favorable "niche" for tumor initiation and progression. The purpose of this review is to discuss the potential therapeutic value of drugs targeting the bone tumor microenvironment in Ewing sarcoma. The first part of the review will focus on targeting the bone resorbing function of osteoclasts by means of bisphosphonates or drugs blocking the pro-resorbing cytokine receptor activator of NF-kappa B ligand. Second, the role of this peculiar hypoxic microenvironment will be discussed in the context of resistance to chemotherapy, escape from the immune system, or neo-angiogenesis. Therapeutic interventions based on these specificities could be then proposed in the context of Ewing sarcoma