416 research outputs found

    Resultados de pesquisa com espécies de inverno: trigo - 1998.

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    Comportamento climatico durante o ciclo da cultura do trigo, em Dourados, MS, safra 1998; Avaliacao de cultivares de trigo em nivel estadual de experimentacao, no sul de Mato Grosso do Sul, safra 1998; Avaliacao de cultivares e linhagens de trigo em nivel final de experimentacao, no sul de Mato Grosso do Sul, safra 1998; Avaliacao de linhagens de trigo em nivel intermediario de experimentacao, no sul de Mato Grosso do Sul, safra 1998; Avaliacao de linhagens de trigo em nivel preliminar de experimentacao, no sul de Mato Grosso do Sul, safra 1998.bitstream/item/65633/1/DOC21-00-Res-Trigo.pd

    Resultados de pesquisa com trigo, triticale e aveia - 2000.

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    Condições climáticas para o Trigo em Mato Grosso do Sul, Safra 2000; Avaliação de cultivares de trigo indicadas para cultivo em Mato Grosso do Sul, Safra 2000; Avaliação de de cultivares de trigo indicadas para cultivo em outros estados do Brasil, safra 2000; Ensaio Brasileiro de Cultivares de Triticale em Dourados, MS, Safra 2000; Ensaio Brasileiro de Cultivares de Aveia Branca em Dourados, MS, Safra 2000.bitstream/item/38284/1/DOC46.pd

    Memoria y balance general: Memoria y balance general - Ejercicio Noveno - 1929 diciembre 31 (31/12/1929)

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

    Resultados de pesquisa com trigo na area de melhoramento genético - safra 1997.

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    bitstream/item/39646/1/doc20.pd

    Memoria y balance general: Memoria y balance general - Ejercicio VIII - 1928 diciembre 31 (31/12/1928)

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

    Editorial: Nck has a knack for T cell differentiation

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    Peer Reviewe

    Modification of cysteine residues by cyclopentenone prostaglandins: Interplay with redox regulation of protein function

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    40 p.-5 fig.-1 tab.Cyclopentenone prostaglandins (cyPG) are endogenous lipid mediators involved in the resolution of inflammation and the regulation of cell proliferation and cellular redox status. Upon exogenous administration they have shown beneficial effects in models of inflammation and tissue injury, as well as potential antitumoral actions, which have raised a considerable interest in their study for the development of therapeutic tools. Due to their electrophilic nature, the best-known mechanism of action of these mediators is the covalent modification of proteins at cysteine residues through Michael addition. Identification of cyPG targets through proteomic approaches, including MS/MS analysis to pinpoint the modified residues, is proving critical to characterize their mechanisms of action. Among the targets of cyPG are proinflammatory transcription factors, proteins involved in cell defense, such as the regulator of the antioxidant response Keap1 and detoxifying enzymes like GST, and key signaling proteins like Ras proteins. Moreover, cyPG may interact with redox-active small molecules, such as glutathione and hydrogen sulfide. Much has been learned about cyPG in the past few years and this knowledge has also contributed to clarify both pharmacological actions and signaling mechanisms of these and other electrophilic lipids. Given the fact that many cyPG targets are involved in or are targets for redox regulation, there is a complex interplay with redox-induced modifications. Here we address the modification of protein cysteine residues by cyPG elucidated by proteomic studies, paying special attention to the interplay with redox signaling.Work in the authors’ laboratory is supported by grants from MINECO SAF2009-11642 and SAF2012-36519, RETIC RIRAAF RD07/0064/0007 and RD12/0013/0008 from ISCIII and COST action CM1001. CLO is the recipient of a FPI fellowship from MINECO.Peer reviewe
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