Identification of Novel Candidate Markers of Type 2 Diabetes and Obesity in Russia by Exome Sequencing with a Limited Sample Size

Type 2 diabetes (T2D) and obesity are common chronic disorders with multifactorial etiology. In our study, we performed an exome sequencing analysis of 110 patients of Russian ethnicity together with a multi-perspective approach based on biologically meaningful filtering criteria to detect novel candidate variants and loci for T2D and obesity. We have identified several known single nucleotide polymorphisms (SNPs) as markers for obesity (rs11960429), T2D (rs9379084, rs1126930), and body mass index (BMI) (rs11553746, rs1956549 and rs7195386) (p < 0.05). We show that a method based on scoring of case-specific variants together with selection of protein-altering variants can allow for the interrogation of novel and known candidate markers of T2D and obesity in small samples. Using this method, we identified rs328 in LPL (p = 0.023), rs11863726 in HBQ1 (p = 8 × 10−5), rs112984085 in VAV3 (p = 4.8 × 10−4) for T2D and obesity, rs6271 in DBH (p = 0.043), rs62618693 in QSER1 (p = 0.021), rs61758785 in RAD51B (p = 1.7 × 10−4), rs34042554 in PCDHA1 (p = 1 × 10−4), and rs144183813 in PLEKHA5 (p = 1.7 × 10−4) for obesity; and rs9379084 in RREB1 (p = 0.042), rs2233984 in C6orf15 (p = 0.030), rs61737764 in ITGB6 (p = 0.035), rs17801742 in COL2A1 (p = 8.5 × 10−5), and rs685523 in ADAMTS13 (p = 1 × 10−6) for T2D as important susceptibility loci in Russian population. Our results demonstrate the effectiveness of whole exome sequencing (WES) technologies for searching for novel markers of multifactorial diseases in cohorts of limited size in poorly studied populations

Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector

This paper presents the measurement of the electroweak production of two jets in association with a $Z\gamma$ pair with the $Z$ boson decaying into two neutrinos. It also presents the search for invisible or partially invisible decays of a Higgs boson with a mass of 125 GeV produced through vector-boson fusion with a photon in the final state. These results use data from LHC proton-proton collisions at $\sqrt{s}$ = 13 TeV collected with the ATLAS detector corresponding to an integrated luminosity of 139 fb$^{-1}$. The event signature, shared by all benchmark processes considered for measurements and searches, is characterized by a significant amount of unbalanced transverse momentum and a photon in the final state, in addition to a pair of forward jets. For electroweak production of $Z\gamma$ in association with two jets, the background-only hypothesis is rejected with an observed (expected) significance of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this process is 1.31$\pm$0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at 95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to invisible particles, assuming the Standard Model production cross-section. The signature is also interpreted in the context of decays of a Higgs boson to a photon and a dark photon. An observed (expected) 95% CL upper limit on the branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV Standard Model Higgs boson production cross-section

The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2

The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb$^{-1}$, 46.9 fb$^{-1}$, and 60.6 fb$^{-1}$ respectively of proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13 TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and $b$-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interaction multiplicities demonstrates how the inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme

The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2

The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb$^{-1}$, 46.9 fb$^{-1}$, and 60.6 fb$^{-1}$ respectively of proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13 TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and $b$-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interaction multiplicities demonstrates how the inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme

ATLAS measurements of CP Violation and Rare decays processes with Beauty mesons

The ATLAS experiment has performed accurate measurements of mixing and CP violation in the neutral B mesons, and also of rare neutral B-meson decays proceeding via electroweak FCNC-suppressed processes. This talk will focus on the latest results from ATLAS, such as rate measurements of B^0_s → mu mu and B^0 → mu mu decaysand CP violation in B_s^0 —> J/psi phi decays. In the latter, the Standard Model predicts the CP violating mixing phase, phi_s, to be very small and its SM value is very well constrained, while in many new physics models large phi_s values are expected. Latest measurements of phi_s and several other parameters describing the B_s^0 —> J/psi phi decays will be reported

Measurement of the weak mixing phase phi_s through time-dependent CP violation in Bs—>J/ψΦ decay in ATLAS - FPCP 2020

In the Standard Model of particle physics, CP violation arises due to a single complex phase in the Cabibbo–Kobayashi–Maskawa (CKM) quark mixing matrix. Precise measurements of the CKM parameters therefore constrain the Standard Model, and may reveal new physics effects. The measurement of the time–dependent decay rates of B0s—>J/psi phi provides a theoretically clean method for extracting CP–violating weak mixing phase phi_s. This talk will present the most recent results from ATLAS on the CP-violating mixing phase phi_s and on several other parameters describing the B0s meson system

Measurement of the CP violation in Bs ->J/ψϕ decays in pp collisions at √s= 13 TeV with the ATLAS detector

In the Standard Model of particle physics, CP violation arises due to a single complex phase in the Cabibbo–Kobayashi–Maskawa (CKM) quark mixing matrix. Precise measurements of the CKM parameters therefore constrain the Standard Model, and may reveal new physics effects. The measurement of the time–dependent decay rates of Bs -> J/ψϕ provides a theoretically clean method for extracting CP–violating weak mixing phase phi_s. This poster will present the most recent results from ATLAS on the CP-violating mixing phase phi_s and on several other parameters describing the Bs meson system

Heavy quark physics at ATLAS and CMS (excluding top)

An overview of the most recent results obtained by ATLAS and CMS collaboration in B-physics is given

Methane Emission Control at the High-Productive Longwall Panels of the Yalevsky Coal Mine

The analysis of the experience of methane emission control at the V. D. Yalevsky mine (Kuznetsk coal basin, Russia) during the series of shallow gassy coal seams mining with the high productive longwall was performed. The analysis of the efficiency of gob degassing by the vertical wells and isolated methane removal by gas-suction fans is performed. The efficiency of reducing the distance between ventilation crosscuts between entries is shown. It is also shown that the problems of providing the longwall high productivity in conditions of increasing the natural gas content in the coal seams are associated with gas emission from the extracted coal seam and the lack of effective methods for its early and preliminary degassing. Recommendations for using advanced mining of close-up coal seams as an effective method of degassing of rock mass within the zone of influence of undermining and overmining are given