The end of the unique myocardial band: Part I. Anatomical considerations

The concept of the ‘unique myocardial band’, which proposes that the ventricular myocardial cone is arranged like skeletal muscle, provides an attractive framework for understanding haemodynamics. The original idea was developed by Francisco Torrent-Guasp. Using boiled hearts and blunt dissection, Torrent-Guasp created a single band of ventricular myocardium extending from the pulmonary trunk to the aortic root, with the band thus constructed encircling both ventricular cavities. Cooked hearts can, however, be dissected in many ways. In this review, we show that the band does not exist as an anatomical entity with defined borders. On the contrary, the ventricular cardiomyocytes are aggregated end to end and by their branching produce an intricate meshwork. Across the thickness of the left ventricular wall, the chains of cardiomyocytes exhibit a gradually changing helical angle, with a circumferential zone formed in the middle. There is no abrupt change in helical angle, as could be expected if the wall was constructed of opposing limbs of a single wrapped band, nor does the long axis of the cardiomyocytes consistently match with the long axis of the unique myocardial band. There are, furthermore, no connective tissue structures that could be considered to demarcate its purported boundaries. The unique myocardial band should be consistent with evolution, and although the ventricular wall of fish and reptiles has one or several distinct layers, a single band is not found. In 1965, Lev and Simpkins cautioned that the ventricular muscle mass of a cooked heart can be dissected almost at the whim of the anatomist. We suggest that the unique myocardial band should have ended there

Linking transitions to sustainability: A study of the societal effects of transition management

Sustainability transitions as processes of fundamental change in societal systems are open-ended, nonlinear and uncertain. Respective research and governance approaches, e.g., transition management, propose a reflexive way of governing, aiming for a number of societal effects to help facilitating a transition. Effects include empowerment, social learning and social capital development. Jointly mentioned effects shall allow for reflexivity and innovation in developing socially robust and contextualized solutions to sustainability challenges that work in practice. But, understanding the mentioned societal effects and their interplay in more depth is necessary to design and assess transition management processes. While such understanding and related assessment framework is under development in the transition management literature, transdisciplinary sustainability research can provide a rich body of tools and experiences. Building on a review of the literature, this article develops an evaluation framework focusing on social learning, empowerment and social capital as important and hitherto under-conceptualised aspects of the sustainability transition literature. This framework is used to empirically investigate the effects of two specific transition management processes at the local scale. In doing so, the article provides a conceptual and empirical understanding of how social learning, empowerment and social capital contribute to a transition towards sustainability. The three effects are shown to be interrelated, mutually supportive and bridging different scale levels from individuals to groups, niches and beyond. Results highlight possibilities to facilitate and assess societal effects, addressing sustainability as their inherent quality

Enhancing Retention for Patient Care Assistants: Effective Strategies to Implement to Reduce Turnover

Develop and implement a hospital-wide, evidence-based recruitment and retention program to reduce turnover rates for Patient Care Assistants (PCAs).https://digitalcommons.centracare.com/nursing_posters/1094/thumbnail.jp

Enhancing Retention for Nursing Assistants: Effective Strategies to Reduce Turnover

Develop and implement a hospital-wide, evidence-based recruitment and retention program to reduce turnover rates for Nursing Assistants (NAs).https://digitalcommons.centracare.com/nursing_posters/1105/thumbnail.jp

The Social Studies Laboratory and Its Use in the Secondary Schools

A vital problem facing us at the present is to find a more effective and interesting method in the teaching of social studies in our high schools so as to prepare pupils, in a limited period of time and in an already overburdened curriculum, for a useful and satisfying life guided by well cultivated social attitudes and ideals. The social studies laboratory, where pupils learn by doing, seems to be indispensable if, with economy of time and space, a thorough course of social studies is to be covered effectively

Bioeconomy Transitions through the Lens of Coupled Social-Ecological Systems: A Framework for Place-Based Responsibility in the Global Resource System

Bioeconomy strategies in high income societies focus at replacing finite, fossil resources by renewable, biological resources to reconcile macro-economic concerns with climate constraints. However, the current bioeconomy is associated with critical levels of environmental degradation. As a potential increase in biological resource use may further threaten the capacity of ecosystems to fulfil human needs, it remains unclear whether bioeconomy transitions in high income countries are sustainable. In order to fill a gap in bioeconomy sustainability assessments, we apply an ontological lens of coupled social-ecological systems to explore critical mechanisms in relation to bioeconomy activities in the global resource system. This contributes to a social-ecological systems (SES)-based understanding of sustainability from a high income country perspective: the capacity of humans to satisfy their needs with strategies that reduce current levels of pressures and impacts on ecosystems. Building on this notion of agency, we develop a framework prototype that captures the systemic relation between individual human needs and collective social outcomes on the one hand (microlevel) and social-ecological impacts in the global resource system on the other hand (macro-level). The BIO-SES framework emphasizes the role of responsible consumption (for physical health), responsible production (to reduce stressors on the environment), and the role of autonomy and selforganisation (to protect the reproduction capacity of social-ecological systems). In particular, the BIO-SES framework can support (1) individual and collective agency in high income country contexts to reduce global resource use and related ecosystem impacts with a bioeconomy strategy, (2) aligning social outcomes, monitoring efforts and governance structures with place-based efforts to achieve the SDGs, as well as (3), advancing the evidence base and social-ecological theory on responsible bioeconomy transitions in the limited biosphere

A social perspective on sustainable transport policy. A case study on car road pricing in Austria

The current transport system in industrialised countries is far from being sustainable, partly due to the negative impacts of motorised individual transport. Car road pricing would present a policy instrument to reduce the transport volume and to change the modal split. However, its effects go beyond the transport system itself and influence the different dimensions of sustainability, especially the social dimension. In the present paper the impacts of different car road pricing scenarios in Austria are discussed. It aims to present the operationalisation of the social dimension and its significance in relation to the other dimensions of sustainability, often represented by a trade-off. Results concerning the impacts of car road pricing on the Austrian population are discussed with regard to the feasibility and acceptance of such a measure. Different options to overcome the negative acceptance of road pricing or to reduce the trade-offs are suggested

How a Mycoparasite Employs G-Protein Signaling: Using the Example of Trichoderma

Mycoparasitic Trichoderma spp. act as potent biocontrol agents against a number of plant pathogenic fungi, whereupon the mycoparasitic attack includes host recognition followed by infection structure formation and secretion of lytic enzymes and antifungal metabolites leading to the host's death. Host-derived signals are suggested to be recognized by receptors located on the mycoparasite's cell surface eliciting an internal signal transduction cascade which results in the transcription of mycoparasitism-relevant genes. Heterotrimeric G proteins of fungi transmit signals originating from G-protein-coupled receptors mainly to the cAMP and the MAP kinase pathways resulting in regulation of downstream effectors. Components of the G-protein signaling machinery such as Gα subunits and G-protein-coupled receptors were recently shown to play crucial roles in Trichoderma mycoparasitism as they govern processes such as the production of extracellular cell wall lytic enzymes, the secretion of antifungal metabolites, and the formation of infection structures

Trichoderma G protein-coupled receptors: functional characterisation of a cAMP receptor-like protein from Trichoderma atroviride

Gα subunits act to regulate vegetative growth, conidiation, and the mycoparasitic response in Trichoderma atroviride. To extend our knowledge on G protein signalling, we analysed G protein-coupled receptors (GPCRs). As the genome sequence of T. atroviride is not publicly available yet, we carried out an in silico exploration of the genome database of the close relative T. reesei. Twenty genes encoding putative GPCRs distributed over eight classes and additional 35 proteins similar to the Magnaporthe grisea PTH11 receptor were identified. Subsequently, four T. atroviride GPCR-encoding genes were isolated and affliated to the cAMP receptor-like family by phylogenetic and topological analyses. All four genes showed lowest expression on glycerol and highest mRNA levels upon carbon starvation. Transcription of gpr3 and gpr4 responded to exogenously added cAMP and the shift from liquid to solid media. gpr3 mRNA levels also responded to the presence of fungal hyphae or cellulose membranes. Further characterisation of mutants bearing a gpr1-silencing construct revealed that Gpr1 is essential for vegetative growth, conidiation and conidial germination. Four genes encoding the first GPCRs described in Trichoderma were isolated and their expression characterized. At least one of these GPCRs is important for several cellular processes, supporting the fundamental role of G protein signalling in this fungus

Trichoderma Biocontrol: Signal Transduction Pathways Involved in Host Sensing and Mycoparasitism

Fungi of the genus Trichoderma are used as biocontrol agents against several plant pathogenic fungi like Rhizoctonia spp., Pythium spp., Botrytis cinerea and Fusarium spp. which cause both soil-borne and leaf- or flower-borne diseases of agricultural plants. Plant disease control by Trichoderma is based on complex interactions between Trichoderma, the plant pathogen and the plant. Until now, two main components of biocontrol have been identified: direct activity of Trichoderma against the plant pathogen by mycoparasitism and induced systemic resistance in plants. As the mycoparasitic interaction is host-specific and not merely a contact response, it is likely that signals from the host fungus are recognised by Trichoderma and provoke transcription of mycoparasitism-related genes