Applicability of the National Comprehensive Cancer Network/Multinational Association of Supportive Care in Cancer Guidelines for Prevention and Management of Chemotherapy-Induced Nausea and Vomiting in Southeast Asia: A Consensus Statement.

A meeting of regional experts was convened in Manila, Philippines, to develop a resource-stratified chemotherapy-induced nausea and vomiting (CINV) management guideline. In patients treated with highly emetogenic chemotherapy in general clinical settings, triple therapy with a serotonin (5-hydroxytryptamine-3 [5-HT3]) antagonist (preferably palonosetron), dexamethasone, and aprepitant is recommended for acute CINV prevention. In resource-restricted settings, triple therapy is still recommended, although a 5-HT3 antagonist other than palonosetron may be used. In both general and resource-restricted settings, dual therapy with dexamethasone (days 2 to 4) and aprepitant (days 2 to 3) is recommended to prevent delayed CINV. In patients treated with moderately emetogenic chemotherapy, dual therapy with a 5-HT3 antagonist, preferably palonosetron, and dexamethasone is recommended for acute CINV prevention in general settings; any 5-HT3 antagonist can be combined with dexamethasone in resource-restricted environments. In general settings, for the prevention of delayed CINV associated with moderately emetogenic chemotherapy, corticosteroid monotherapy on days 2 and 3 is recommended. If aprepitant is used on day 1, it should be continued on days 2 and 3. Prevention of delayed CINV with corticosteroids is preferred in resource-restricted settings. The expert panel also developed CINV management guidelines for anthracycline plus cyclophosphamide combination schedules, multiday cisplatin, and chemotherapy with low or minimal emetogenic potential, and its recommendations are detailed in this review. Overall, these regional guidelines provide definitive guidance for CINV management in general and resource-restricted settings. These consensus recommendations are anticipated to contribute to collaborative efforts to improve CINV management in Southeast Asia

Development and characterisation study of liposomes-encapsulated piroxicam.

The objective of present work was to develop a novel liposomes-based drug delivery system for a lipophilic non-steroidal anti-inflammatory drug, piroxicam. The system was prepared using proliposomes method and optimised for different preparation parameters including type of proliposomes, concentration of drug, duration of hydration and type of particle size reduction treatment used. All prepared liposomal samples were extensively characterized for their drug-entrapment and size profile using various in-vitro techniques. Present work showed that the most optimum formulation (Pro-lipoTM Duo; 12mg piroxicam per gram Pro-lipoTM; 10 hours hydration time) produced highest amount of actual drug been entrapped in liposomes (800.4 mg/g Pro-lipoTM) with a satisfactory entrapment efficiency of 15.36%. This formulation had also produced liposomal samples with a homogenous (polydispersity index = 0.45) and small particle size (359.95nm). Extrusion technique was found to cause significant reduction in drug-entrapment and size profile of drug-loaded liposomes. A 4-weeks storage study showed that drug-entrapment and size profile of liposomal samples were stable in both refrigerated and room temperature. Electron microscopy revealed that prepared liposomal samples were spherical-shaped and showed concentric lamellae. In conclusion, present work successfully demonstrated a simple, reproducible and practical method of preparation for liposomes-encapsulated piroxicam

Ice Machine Design Es Puter for Small Industries and Household With Quality Function Deployment Method (QFD)

Designing icemakers (es puter) technology (hard ice cream) have evolved from manual to automatic . In designing a tool not only to consider the technological aspects but also pay attention to other aspects in accordance with the needs and the level of consumer interest . Therefore needed an alternative design Es Puter making machine with the application of the method of Quality Function Deployment ( QFD ), to find and translate the desires and needs of consumers in small industry and households . Through the stages of the design process and product development , as well as the results of the questionnaire are tabulated in QFD found that respondents wanted the  machine of es puter -power, ease of maintenance and has a reliable and produce good quality products . From the research produced a prototype for an ice machine puter with a 12V DC electric motor drive 40W , portable design, with a production capacity of 5 liters each. And equipped with automatic key features , 12V 7Ah battery and place the glass for presentation. Keywords : Es Puter , QFD, Small Industrie

Charged Higgs boson contribution to νˉe−e\bar{\nu}_e-e scattering from low to ultrahigh energy in Higgs triplet model

We study the $\bar{\nu}_e-e$ scattering from low to ultrahigh energy in the framework of Higgs Triplet Model (HTM). We add the contribution of charged Higgs boson exchange to the total cross section of the scattering. We obtain the upper bound $h_{ee}/M_{H^\pm}\lesssim2.8\times10^{-3}GeV^{-1}$ in this process from low energy experiment. We show that by using the upper bound obtained, the charged Higgs contribution can give enhancements to the total cross section with respect to the SM prediction up to 5.16% at $E\leq10^{14}$ eV and maximum at $s\approx M_{H^\pm}^2$ and would help to determine the feasibility experiments to discriminate between SM and HTM at current available facilities.Comment: 6 pages, 6 figure

Methylation levels of a novel genetic element, EgNB3 as a candidate biomarker associated with the embryogenic competency of oil palm

The association between DNA methylation status and embryogenic competency in oil palm tissue culture was examined through Representational Difference Analysis (RDA) approach, using methylation-sensitive restriction endonucleases. "Difference Products" (DPs) of RDA derived from palms of similar genetic backgrounds but exhibiting different embryogenesis rates during the regeneration process were isolated. The DPs were sequenced using a pyrosequencing platform. To our knowledge, this is the first study profiling partial HpaII methylation sites in oil palm young leaf tissues which are potentially associated with embryogenic amenability through a genomic subtractive approach. Quantitative real-time PCR analysis demonstrated that the methylation status of a novel fragment, EgNB3, was higher in highly embryogenic leaf explants compared to low embryogenesis rate materials. These differences are likely to be contributed by the 5′-mCCGG-3′ and/or 5′-mCmCGG-3′ methylation patterns. Our data suggest that the differentially methylated site in EgNB3 has potential as a molecular biomarker for the screening of oil palm leaf explants for their embryogenic potentials

Characterization of Wideband Semiconductor Optical Amplifiers based on OptiSystem and MATLAB

A study about different types of semiconductor optical amplifiers (SOA)s - linear, nonlinear and in-line SOAs modelling is carried out. The SOA key performance characteristics covered in this paper include optical gain, power, and amplified spontaneous emission (ASE) noise figure. These characteristics definition are included in this work together with the tabulation of each SOA specification parameter operating in the operational conventional (C-) band. The first modelling of SOA wideband travelling wave (TW) component is done through a simple configuration using OptiSystem software. Next, the second modelling method is simulated through numerical steady-state model using MATLAB software. Each graphical result is explained and discussed according to the operational characteristic theories of SOA along with the evaluation for the best performance among the types of SOAs. The contrasted result among them had shown that linear SOA has the most ideal and competitive characteristics, as compared to the nonlinear and in-line SOAs, especially a better choice as gain medium in the multiwavelength fiber laser (MWFL) application

Analisis dan Peningkatan Kualitas Proses Taper pada Industri Pegas dengan Pendekatan Lean Six Sigma

XYZ merupakan industri Pegas nasional dengan produk utama Pegas Daun (leaf spring) dan Pegas Keong (coil spring). Hasil laporan produksi diketahui adanya, produk cacat, waiting time dan scraps dalam jumlah yang cukup signifikan. Penelitian ini mempunyai tujuan untuk menyelesaikan masalah dalam proses produksi pegas dengan pendekatan Lean Six Sigma dan FMEA. Identifikasi waste dilakukan melalui Value Stream Mapping untuk mengetahui aktivitas value added dan non-value added. Tahapan DMAIC (define, measure, analyse, improve, control) digunakan untuk implementasi six sigma. Hasil penelitian menunjukkan bahwa proses Taper pada Pegas Daun memiliki biaya repair tertinggi pada COPQ (Cost Of Poor Quality) sebesar 70%. Penerapan Lean Six Sigma menunjukkan efektivitas dalam proses Taper. Waste material sebesar 1.2% turun menjadi 0%, extra processing dan waiting dari 16.67 Jam menjadi 0 Jam. Waste defect disebabkan oleh cacat Burrs rata-rata 6% turun menjadi 0%. Sebelum perbaikan, nilai DPMO adalah 16,880 dengan level sigma 3.62, sedangkan setelah perbaikan menjadi 5,027 dengan level sigma 4.92

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexit