Influence of milk source on transplantability of histocompatible mammary tumours in mice.

It is confirmed that C3H mammary tumours are much more easily transplantable in histocompatible recipients when these have been reared on C3H milk, than when they have been reared on milk from the inbred Swiss/B strain. By contrast, A.CA mammary tumours transplanted in histocompatible hosts reared on A.CA or Swiss/B milk, grow almost equally well in both sorts of recipient. Thus, rearing on Swiss/B milk has different effects on the transplantability of mammary tumours of C3H and A.CA. On the other hand, recipients which were reared on C3H or A.CA milks accept grafts of C3H mammary tumours about equally, suggesting that milks from A.CA and C3H have the same effect on the transplantability of C3H mammary tumours. The different action of Swiss/B milk on tumours of C3H and A.CA seems best attributed to differences between C3H and A.CA tumours or between mouse strain genotypes. By contrast, the transplantability of C3H mammary tumours is significantly changed when the recipients were reared on milk from the RIII strain instead of C3H. These facts suggest that the milk from RIII has an action which differs from that of both C3H and A.CA in this respect. The data are discussed on the basis of a differential tollerance-inducing action of mammary tumour viruses (MTVs) which infect C3H, A.CA and RIII, and have an important role in tumour induction

Genioplasty with surgical guide using 3D-printing technology : a systematic review

The purpose of this systematic review is to evaluate the current state of the art of making genioplasties using 3D printing technology. A multi-database single-reviewer systematic review identified sixteen papers that fulfilled the selection criteria. There were mainly case series and case reports available (Level IV of the Oxford Evidence-based medicine scale); only two prospective study (Level III) evaluated this subject. These articles are analyzed in details and summarized in this review. The realization of genioplasties with surgical guide using 3D-printing technology could improve predictability and accuracy. It protects anatomical structures in the environment of the surgery, reducing by this way the morbidity and providing safer results. The type of printer and material used as well as the sterilization techniques should be further developed by the authors. The use of open-access software should also be further explored to allow the use of these new technologies by the largest number of surgeons. Finally, prospective multi-center studies with larger samples should be performed to definitively conclude the benefits of this new technology and allow for its routine use. This article is the first systematic review on this topic

Seismic evidence for thermal runaway during intermediate-depth earthquake rupture

Intermediate-depth earthquakes occur at depths where temperatures and pressures exceed those at which brittle failure is expected. There are two leading candidates for the physical mechanism behind these earthquakes: dehydration embrittlement and self-localizing thermal shear runaway. A complete energy budget for a range of earthquake sizes can help constrain whether either of these mechanisms might play a role in intermediate-depth earthquake rupture. The combination of high stress drop and low radiation efficiency that we observe for M[subscript w] 4–5 earthquakes in the Bucaramanga Nest implies a temperature increase of 600–1000°C for a centimeter-scale layer during earthquake failure. This suggests that substantial shear heating, and possibly partial melting, occurs during intermediate-depth earthquake failure. Our observations support thermal shear runaway as the mechanism for intermediate-depth earthquakes, which would help explain differences in their behavior compared to shallow earthquakes.National Science Foundation (U.S.) (Grant EAR-1045684

Evaluation and optimization of seismic networks and algorithms for earthquake early warning – the case of Istanbul (Turkey)

Earthquake early warning (EEW) systems should provide reliable warnings as quickly as possible with a minimum number of false and missed alarms. Using the example of the megacity Istanbul and based on a set of simulated scenario earthquakes, we present a novel approach for evaluating and optimizing seismic networks for EEW, in particular in regions with a scarce number of instrumentally recorded earthquakes. We show that, while the current station locations of the existing Istanbul EEW system are well chosen, its performance can be enhanced by modifying the parameters governing the declaration of warnings. Furthermore, unless using ocean bottom seismometers or modifying the current EEW algorithm, additional stations might not lead to any significant performance increase

Existence of a rotating wave pattern in a disk for a wave front interaction model

[[abstract]]We study the rotating wave patterns in an excitable medium in a disk. This wave pattern is rotating along the given disk boundary with a constant angular speed. To study this pattern we use the wave front interaction model proposed by Zykov in 2007. This model is derived from the FitzHugh-Nagumo equation and it can be described by two systems of ordinary differential equations for wave front and wave back respectively. Using a delicate shooting argument with the help of the comparison principle, we derive the existence and uniqueness of rotating wave patterns for any admissible angular speed with convex front in a given disk.[[incitationindex]]SCI[[booktype]]紙本[[booktype]]電子

Source processes and spectral ground motion models of intermediate depth Vrancea (Romania) earthquakes

For successful assessment and mitigation of earthquake hazards, it is necessary to be able to reliably predict the level of ground shaking which has to be expected from future large earthquakes. This prediction of ground motion can be done either by using empirical relations (derived from past earthquakes) between some ground motion parameter and the source and observer location, so-called attenuation relations, or by performing numerical simulations of future earthquakes based on models of the earthquake source and the propagation medium (i.e. the Earth). The capacity of the first option is at times rather limited, for instance if only very few large earthquakes occurred in the region of interest in instrumental times. Numerical simulations, on the other hand, cannot provide reliable results without a detailed description of the underlying source process and a thorough understanding of path and site effects. This thesis aims at a better understanding of the source process and the spectral characteristics of the intermediate-depth Vrancea (Romania) earthquakes...thesi