Disease Localization in Multilayer Networks

We present a continuous formulation of epidemic spreading on multilayer networks using a tensorial representation, extending the models of monoplex networks to this context. We derive analytical expressions for the epidemic threshold of the SIS and SIR dynamics, as well as upper and lower bounds for the disease prevalence in the steady state for the SIS scenario. Using the quasi-stationary state method we numerically show the existence of disease localization and the emergence of two or more susceptibility peaks, which are characterized analytically and numerically through the inverse participation ratio. Furthermore, when mapping the critical dynamics to an eigenvalue problem, we observe a characteristic transition in the eigenvalue spectra of the supra-contact tensor as a function of the ratio of two spreading rates: if the rate at which the disease spreads within a layer is comparable to the spreading rate across layers, the individual spectra of each layer merge with the coupling between layers. Finally, we verified the barrier effect, i.e., for three-layer configuration, when the layer with the largest eigenvalue is located at the center of the line, it can effectively act as a barrier to the disease. The formalism introduced here provides a unifying mathematical approach to disease contagion in multiplex systems opening new possibilities for the study of spreading processes.Comment: Revised version. 25 pages and 18 figure

Fano resonances in plasmonic core-shell particles and the Purcell effect

Despite a long history, light scattering by particles with size comparable with the light wavelength still unveils surprising optical phenomena, and many of them are related to the Fano effect. Originally described in the context of atomic physics, the Fano resonance in light scattering arises from the interference between a narrow subradiant mode and a spectrally broad radiation line. Here, we present an overview of Fano resonances in coated spherical scatterers within the framework of the Lorenz-Mie theory. We briefly introduce the concept of conventional and unconventional Fano resonances in light scattering. These resonances are associated with the interference between electromagnetic modes excited in the particle with different or the same multipole moment, respectively. In addition, we investigate the modification of the spontaneous-emission rate of an optical emitter at the presence of a plasmonic nanoshell. This modification of decay rate due to electromagnetic environment is referred to as the Purcell effect. We analytically show that the Purcell factor related to a dipole emitter oriented orthogonal or tangential to the spherical surface can exhibit Fano or Lorentzian line shapes in the near field, respectively.Comment: 28 pages, 10 figures; invited book chapter to appear in "Fano Resonances in Optics and Microwaves: Physics and Application", Springer Series in Optical Sciences (2018), edited by E. O. Kamenetskii, A. Sadreev, and A. Miroshnichenk

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X.

BackgroundActivated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin. There are no reports of humans with complete deficiency of FX, and knockout of murine F10 is embryonic or perinatal lethal.ObjectiveWe sought to generate a viable mouse model of FX deficiency.MethodsWe used a socket-targeting construct to generate F10-knockout mice by eliminating F10 exon 8 (knockout allele termed F10(tm1Ccmt), abbreviated as '-'; wild-type '+'), and a plug-targeting construct to generate mice expressing a FX variant with normal antigen levels but low levels of FX activity [4-9% normal in humans carrying the defect, Pro343-->Ser, termed FX Friuli (mutant allele termed F10(tm2Ccmt), abbreviated as F)].ResultsF10 knockout mice exhibited embryonic or perinatal lethality. In contrast, homozygous Friuli mice [F10 (F/F)] had FX activity levels of approximately 5.5% (sufficient to rescue both embryonic and perinatal lethality), but developed age-dependent iron deposition and cardiac fibrosis. Interestingly, F10 (-/F) mice with FX activity levels of 1-3% also showed complete rescue of lethality. Further study of this model provides evidence supporting a role of maternal FX transfer in the embryonic survival.ConclusionsWe demonstrate that, while complete absence of FX is incompatible with murine survival, minimal FX activity as low as 1-3% is sufficient to rescue the lethal phenotype. This viable low-FX mouse model will facilitate the development of FX-directed therapies as well as investigation of the FX role in embryonic development

Cerenkov angle and charge reconstruction with the RICH detector of the AMS experiment

The Alpha Magnetic Spectrometer (AMS) experiment to be installed on the International Space Station (ISS) will be equipped with a proximity focusing Ring Imaging Cerenkov (RICH) detector, for measurements of particle electric charge and velocity. In this note, two possible methods for reconstructing the Cerenkov angle and the electric charge with the RICH, are discussed. A Likelihood method for the Cerenkov angle reconstruction was applied leading to a velocity determination for protons with a resolution of around 0.1%. The existence of a large fraction of background photons which can vary from event to event, implied a charge reconstruction method based on an overall efficiency estimation on an event-by-event basis.Comment: Proceedings submitted to RICH 2002 (Pylos-Greece

Tolerância ao calor de caprinos e ovinos sem-lã em Sobral.

Resumo: Caprinos das raças Canindé, Anglo-Nubiana e Bhuj e avinos sem-la Morada Nova e Santa Inês foram comparados quanta às temperaturas retais e taxa respiratoria, antes e imediatamente apos o exercício e durante o período de uma hora de repouso apos o0 exercicio, para avaliaçao da tolerância ao calor ambiental. Resultados mostraram que a temperatura retal inicial nao foi diferente entre as cinco raças; apos exercicio, elevou de 1,25ºC até 1,95ºC nas diferentes raças; nao houve diferença da elevaçao da temperatura corporal entre espécies. Apos exercício, a recuperaçao foi rapida nos caprinos Bhuj e Canindé. A recuperaçao foi mais lenta na Anglo-Nubiana e nos avinos. A variaçao inicial no ritmo respiratorio apresentou-se elevada na Anglo-Nubiana em comparaçao com as outras raças de caprinos e avinos. Depois do exercicio, os avinos apresentaram menoI elevaçao no ritmo respiratorio do que os caprinos. Isto pode explicar o grau de recuperaçao mais rapida da temperatura corporal dos caprinos Bhuj e Canindé, os quais tiveram distintamente os mais elevados ritmos respiratorios após o exercicio. 0 ritmo respiratório da Anglo-Nubiana voltou ao normal dentro de 15 minutas apos o exercicio; somente o da Bhuj continuou elevado após os 15 minutos de descanso. Todas as espécies voltaram ao ritmo respiratório normal, após os trinta minutos de descanso. [Heat tolerance of goats and woolless sheep in Sobral Brazil]

Morphofunctional evaluation of thymus in hyperglycemic-hypoinsulinemic mice during dermatophytic infection

Many works have shown that the enhanced susceptibility to infection seen in diabetic patients can be related to the hyperglycemia-hypoinsulinemia (HH) observed in this condition. Herein, we evaluated the HH effects on the morphofunctional features of the thymus as well as on dermatophytic infection. We demonstrated that, not only the HH condition but also the dermatophytic infection induced transitory alterations in the thymus; it was characterized by loss of cortical-medullar definition and disorganization of the extracellular matrix. These mice also showed a decrease of CD4+CD8+ thymocytes and a higher percentage of CD4+CD8+ lymphocytes in the peripheral blood. After 7 days, the thymus and peripheral lymphocytes subsets returned to normal values. Interestingly, when the two conditions, HH condition and the infection, were associated, the mice showed a decrease in the percentage of CD4+CD8- blood lymphocytes that are involved in the modulation of immune response and have direct cytotoxic effects on the fungus. Taken together, our results showed that both conditions transitorily changed the thymus, but only when both these conditions are present do they trigger persistent changes that might be responsible for the higher susceptibility to dermatophytosis seen in HH patients.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP Univ Estadual Paulista, Lab Imunopatol Expt, Fac Ciencias, Dept Ciencias Biol, BR-17033360 Bauru, SP, BrazilUNESP Univ Estadual Paulista, Fac Med Botucatu, Botucatu, SP, BrazilUNIFESP Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilUNIFESP Universidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, BrazilWeb of Scienc