2,109 research outputs found
Evaluation of Agents Interactions in a Context-Aware System
The evaluation of Multi-Agent Systems (MAS) is a complex problem and it does not have a single form. Much effort has been spent on suggesting and implementing new architectures of MAS. Often these new architectures are not even compared to any other existing architectures in order to evaluate their relative benefits. The present work focuses on interactions, the most important characteristic of any complex software as autonomous agents according to [25], as a problematic of evaluation. So, in this paper, we describe the assignment of evaluation values to Agents interaction in a specific MAS architecture. This evaluation is based on the weight of the messages brought by an interaction.Funded by projects CICYT TIN2008-06742-C02-02/TSI,CICYT TEC2008-06732-C02-02/TEC, SINPROB, CAM MADRINET S-0505/TIC/0255, and DPS2008-07029-C02-02.Publicad
Divergent effects of liraglutide, exendin-4, and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycaemia
AIMS:Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP4) inhibitors improve glucose tolerance by still incompletely understood mechanisms. Each class of antihyperglycemic drugs has also been proposed to increase pancreatitis risk. Here, we compare systematically the effects of two widely-used GLP-1 analogues, liraglutide and exendin-4, and the DPP4 inhibitor, sitagliptin, in the mouse. METHODS:C57BL6 mice were maintained for 131 days on a normal diet (ND) or a diet comprising 60% fat (HFD) before measurements of fasting blood glucose and insulin, and intraperitoneal glucose tolerance. Beta- and alpha- cell volume, and Reg3b immunoreactivity, were measured by immunohistochemical analysis of pancreatic slices. RESULTS:Whereas liraglutide (200 µg/kg) and exendin-4 (10 µg/kg) treatment reduced body weight and/or improved glucose tolerance, sitagliptin (10 mg/kg) was without effect on either parameter. Liraglutide caused a sharp reduction in beta-cell mass in both ND and HFD mice, whereas exendin-4 exerted no effect. By contrast, sitagliptin unmasked an action of high fat diet to increase beta-cell mass. Reg3B positive area was augmented by all three agents in normal chow-fed mice, whilst sitagliptin and exendin-4, but not liraglutide, affected this parameter in HFD animals. Correspondingly sitagliptin, but not the GLP-1 analogues, increased circulating amylase levels in ND and HFD mice. CONCLUSIONS:Liraglutide improves glucose tolerance in the mouse whilst exerting relatively modest effects on pancreatitis risk. Conversely, exendin-4 and sitagliptin, at doses which exert, respectively, minor or no effects on metabolic parameters, lead to signs of pancreatitis
Implications of the Small Spin Changes Measured for Large Jupiter-Family Comet Nuclei
Rotational spin-up due to outgassing of comet nuclei has been identified as a possible mechanism for considerable mass-loss and splitting. We report a search for spin changes for three large Jupiter-family comets (JFCs): 14P/Wolf, 143P/Kowal-Mrkos, and 162P/Siding Spring. None of the three comets has detectable period changes, and we set conservative upper limits of 4.2 (14P), 6.6 (143P) and 25 (162P) minutes per orbit. Comparing these results with all eight other JFCs with measured rotational changes, we deduce that none of the observed large JFCs experiences significant spin changes. This suggests that large comet nuclei are less likely to undergo rotationally-driven splitting, and therefore more likely to survive more perihelion passages than smaller nuclei. We find supporting evidence for this hypothesis in the cumulative size distributions of JFCs and dormant comets, as well as in recent numerical studies of cometary orbital dynamics. We added 143P to the sample of 13 other JFCs with known albedos and phase-function slopes. This sample shows a possible correlation of increasing phase-function slopes for larger geometric albedos. Partly based on findings from recent space missions to JFCs, we hypothesise that this correlation corresponds to an evolutionary trend for JFCs. We propose that newly activated JFCs have larger albedos and steeper phase functions, which gradually decrease due to sublimation-driven erosion. If confirmed, this could be used to analyse surface erosion from ground and to distinguish between dormant comets and asteroids
SAJaS: enabling JADE-based simulations
Multi-agent systems (MAS) are widely acknowledged as an appropriate modelling paradigm for distributed and decentralized systems, where a (potentially large) number of agents interact in non-trivial ways. Such interactions are often modelled defining high-level interaction protocols. Open MAS typically benefit from a number of infrastructural components that enable agents to discover their peers at run-time. On the other hand, multi-agent-based simulations (MABS) focus on applying MAS to model complex social systems, typically involving a large agent population. Several MAS development frameworks exist, but they are often not appropriate for MABS; and several MABS frameworks exist, albeit sharing little with the former. While open agent-based applications benefit from adopting development and interaction standards, such as those proposed by FIPA, MABS frameworks typically do not support them. In this paper, a proposal to bridge the gap between MAS simulation and development is presented, including two components. The Simple API for JADE-based Simulations (SAJaS) enhances MABS frameworks with JADE-based features. While empowering MABS modellers with modelling concepts offered by JADE, SAJaS also promotes a quicker development of simulation models for JADE programmers. In fact, the same implementation can, with minor changes, be used as a large scale simulation or as a distributed JADE system. In its current version, SAJaS is used in tandem with the Repast simulation framework. The second component of our proposal consists of a MAS Simulation to Development (MASSim2Dev) tool, which allows the automatic conversion of a SAJaS-based simulation into a JADE MAS, and vice-versa. SAJaS provides, for certain kinds of applications, increased simulation performance. Validation tests demonstrate significant performance gains in using SAJaS with Repast when compared with JADE, and show that the usage of MASSim2Dev preserves the original functionality of the system. © Springer-Verlag Berlin Heidelberg 2015
The Cratering History of Asteroid (2867) Steins
The cratering history of main belt asteroid (2867) Steins has been
investigated using OSIRIS imagery acquired during the Rosetta flyby that took
place on the 5th of September 2008. For this purpose, we applied current models
describing the formation and evolution of main belt asteroids, that provide the
rate and velocity distributions of impactors. These models coupled with
appropriate crater scaling laws, allow the cratering history to be estimated.
Hence, we derive Steins' cratering retention age, namely the time lapsed since
its formation or global surface reset. We also investigate the influence of
various factors -like bulk structure and crater erasing- on the estimated age,
which spans from a few hundred Myrs to more than 1Gyr, depending on the adopted
scaling law and asteroid physical parameters. Moreover, a marked lack of
craters smaller than about 0.6km has been found and interpreted as a result of
a peculiar evolution of Steins cratering record, possibly related either to the
formation of the 2.1km wide impact crater near the south pole or to YORP
reshaping.Comment: Accepted by Planetary and Space Scienc
Evolution of the Dust Coma in Comet 67P/Churyumov-Gerasimenko Before 2009 Perihelion
Comet 67P/Churyumov-Gerasimenko is the main target of ESA's Rosetta mission
and will be encountered in May 2014. As the spacecraft shall be in orbit the
comet nucleus before and after release of the lander {\it Philae}, it is
necessary necessary to know the conditions in the coma. Study the dust
environment, including the dust production rate and its variations along its
preperihelion orbit. The comet was observed during its approach to the Sun on
four epochs between early-June 2008 and mid-January 2009, over a large range of
heliocentric distances that will be covered by the mission in 2014. An
anomalous enhancement of the coma dust density was measured towards the comet
nucleus. The scalelength of this enhancement increased with decreasing
heliocentric distance of the comet. This is interpreted as a result of an
unusually slow expansion of the dust coma. Assuming a spherical symmetric coma,
the average amount of dust as well as its ejection velocity have been derived.
The latter increases exponentially with decreasing heliocentric distance (\rh),
ranging from about 1 m/s at 3 AU to about 25-35 m/s at 1.4 AU. Based on these
results we describe the dust environment at those nucleocentric distances at
which the spacecraft will presumably be in orbit.
Astronomy and Astrophysics, in pressComment: 5 pages, 4 figure
Observing the variation of asteroid thermal inertia with heliocentric distance
Thermal inertia is a useful property to characterise a planetary surface since it can be used as a qualitative measure of the regolith grain size. It is expected to vary with heliocentric distance because of its dependence on temperature. However, no previous investigation has conclusively observed a change in thermal inertia for any given planetary body. We have addressed this by using NEOWISE data and the Advanced Thermophysical Model to study the thermophysical properties of the near-Earth asteroids (1036) Ganymed, (1580) Betulia, and (276049) 2002 CE26 as they moved around their highly eccentric orbits. We confirm that the thermal inertia values of Ganymed and 2002 CE26 do vary with heliocentric distance, although the degree of variation observed depends on the spectral emissivity assumed in the thermophysical modelling. We also confirm that the thermal inertia of Betulia did not change for three different observations obtained at the same heliocentric distance. Depending on the spectral emissivity, the variations for Ganymed and 2002 CE26 are potentially more extreme than that implied by theoretical models of heat transfer within asteroidal regoliths, which might be explained by asteroids having thermal properties that also vary with depth. Accounting for this variation reduces a previously observed trend of decreasing asteroid thermal inertia with increasing size, and suggests that the surfaces of small and large asteroids could be much more similar than previously thought. Furthermore, this variation can affect Yarkovsky orbital drift predictions by a few tens of per cent
Co-firing of biomass and other wastes in fluidised bed systems
A project on co-firing in large-scale power plants burning coal is currently funded by the European Commission. It is called COPOWER. The project involves 10 organisations from 6 countries. The project involves combustion studies over the full spectrum of equipment size, ranging from small laboratory-scale reactors and pilot plants, to investigate fundamentals and operating parameters, to proving trials on a commercial power plant in Duisburg. The power plant
uses a circulating fluidized bed boiler. The results to be obtained are to be compared as function of scale-up. There are two different coals, 3 types of biomass and 2 kinds of waste materials are to be used for blending with coal for co-firing tests. The baseline values are obtained during a campaign of one month at the power station and the results are used for comparison with those to be obtained in other units of various sizes. Future tests will be implemented with the objective to achieve improvement on baseline values. The fuels to be used are already characterized. There are ongoing studies to determine reactivities of fuels and chars produced from the fuels. Reactivities are determined not only for individual fuels but also for blends to be used. Presently pilot-scale combustion tests are also undertaken to study the effect of blending coal with different types of biomass and waste materials. The potential for synergy to improve combustion is investigated. Early results will be reported in the Conference. Simultaneously, studies to verify the availability of biomass and waste materials in Portugal, Turkey and Italy have been undertaken. Techno-economic barriers for the future use of biomass and other waste materials are identified. The potential of using these materials in coal fired power stations has been assessed. The conclusions will also be reported
Creating university spin-offs: A science-based design perspective
Academic entrepreneurship by means of university spin-offs commercializes technological breakthroughs, which may otherwise remain unexploited. However, many universities face difficulties in creating spin-offs. This article adopts a science-based design approach to connect scholarly research with the pragmatics of effectively creating university spin-offs. This approach serves to link the practice of university spin-off creation, via design principles, to the scholarly knowledge in this area. As such, science-based design promotes the interplay between emergent and deliberate design processes. This framework is used to develop a set of design principles that are practice based as well as grounded in the existing body of research on university spin-offs. A case-study of spin-off creation at a Dutch university illustrates the interplay between initial processes characterized by emergent design and the subsequent process that was more deliberate in nature. This case study also suggests there are two fundamentally different phases in building capacity for university spin-off creation. First, an infrastructure for spin-off creation (including a collaborative network of investors, managers and advisors) is developed that then enables support activities to individual spin-off ventures. This study concludes that to build and increase capacity for creating spin-offs, universities should do the following: (1) create university-wide awareness of entrepreneurship opportunities, stimulate the development of entrepreneurial ideas, and subsequently screen entrepreneurs and ideas by programs targeted at students and academic staff; (2) support start-up teams in composing and learning the right mix of venturing skills and knowledge by providing access to advice, coaching, and training; (3) help starters in obtaining access to resources and developing their social capital by creating a collaborative network organization of investors, managers, and advisors; (4) set clear and supportive rules and procedures that regulate the university spin-off process, enhance fair treatment of involved parties, and separate spin-off processes from academic research and teaching; and (5) shape a university culture that reinforces academic entrepreneurship by creating norms and exemplars that motivate entrepreneurial behavior. These and other results of this study illustrate how science-based design can connect scholarly research to the pragmatics of actually creating spin-offs in academic institutions
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