Real estate loans of registrants under Regulation X

Regulation X: Borrowers of Securities Credit ; Mortgage loans - Law and legislation

Retail Innovation - The never-ending road to success? A critical analysis of pitfalls and opportunities

This paper outlines the current and continuous changes occurring in the retail and social environment that necessitate the constant evolution of retail formats. Over recent years experiential retail formats have appeared in recognition of the increasing need to ‘entertain’ shoppers and satisfy their ‘leisure’ needs. A number of ‘best practice’ examples of such retail innovation have been presented. While such experiential innovations appear to be the ‘holy grail’ of modern retailing, they often require considerable investments of both capital and management time. This paper has used an autoethnographic approach to reflect upon the constraints and costs involved in the design, construction and operation of such a retail enterprise to provide a unique and holistic assessment of the benefits and challenges experiential innovation holds in developing new retail formats and initiatives. The findings from this research highlight a number of previously unreported pitfalls that are likely to be encountered, financially, operationally and symbolically. It is recommended that retailers continue to explore experiential innovations, but that they proceed with caution

An Open Resource for Non-human Primate Imaging

Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience. Unfortunately, the technological and methodological advances of the past two decades have outpaced the accrual of data, which is particularly challenging given the relatively few centers that have the necessary facilities and capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human primate magnetic resonance imaging (MRI) datasets and openly sharing them via the International Neuroimaging Data-sharing Initiative (INDI). Here, we present the rationale, design, and procedures for the PRIME-DE consortium, as well as the initial release, consisting of 25 independent data collections aggregated across 22 sites (total = 217 non-human primates). We also outline the unique pitfalls and challenges that should be considered in the analysis of non-human primate MRI datasets, including providing automated quality assessment of the contributed datasets

Fine-Scale Spatial Organization of Face and Object Selectivity in the Temporal Lobe: Do Functional Magnetic Resonance Imaging, Optical Imaging, and Electrophysiology Agree?

The spatial organization of the brain's object and face representations in the temporal lobe is critical for understanding high-level vision and cognition but is poorly understood. Recently, exciting progress has been made using advanced imaging and physiology methods in humans and nonhuman primates, and the combination of such methods may be particularly powerful. Studies applying these methods help us to understand how neuronal activity, optical imaging, and functional magnetic resonance imaging signals are related within the temporal lobe, and to uncover the fine-grained and large-scale spatial organization of object and face representations in the primate brain

A review of volatiles in the Martian interior

Multiple observations from missions to Mars have revealed compelling evidence for a volatile-rich Martian crust. A leading theory contends that eruption of basaltic magmas was the ultimate mechanism of transfer of volatiles from the mantle toward the surface after an initial outgassing related to the crystallization of a magma ocean. However, the concentrations of volatile species in ascending magmas and in their mantle source regions are highly uncertain. This work and this special issue of Meteoritics & Planetary Science summarize the key findings of the workshop on Volatiles in the Martian Interior (Nov. 3–4, 2014), the primary open questions related to volatiles in Martian magmas and their source regions, and the suggestions of the community at the workshop to address these open questions

Carbon storage in cacao (Theobroma cacao) plantations in Armero-Guayabal (Tolima, Colombia)

P?ginas 6-10El cambio clim?tico sigue siendo la principal amenaza de la humanidad hoy en d?a. Esta problem?tica se ha incrementado debido a las acciones humanas, como el uso de combustibles f?siles, la deforestaci?n y la degradaci?n. La comunidad mundial organizada ha establecido esquemas para mitigar este problema ambiental, por ejemplo el mecanismo de desarrollo limpio. Los sistemas agroforestales con cacao son considerados como mitigadores del cambio clim?tico por capturar carbono en biomasa, necromasa y suelos. Se estim? el almacenamiento y la fijaci?n de carbono en biomasa arriba del suelo y necromasa de cacaotales de 18 y 35 a?os de edad en el Centro Universitario Regional del Norte, en Armero-Guayabal (Tolima, Colombia) CURDN. Los cacaotales estudiados almacenaron 28.8 y 33.6 t C ha-1 en biomasa arriba del suelo a los 18 y 35 a?os, respectivamente, que arrojaron una tasa de fijaci?n promedio de 1.1 t C ha-1 a?o-1 . El carbono almacenado en necromasa ascendi? a 4.4 t ha-1 , con diferencias leves entre las edades de las plantaciones. Los sistemas agroforestales con cacao en Armero-Guayabal (Tolima, Colombia) tienen potencial para mitigar el cambio clim?tico al capturar carbono en biomasa y necromasa.ABSTRACT. Climate change holds as the current main threat of the humankind. This problem has being increasing by human actions such as the use of fossil fuels, deforestation and degradation. The organized world community has established schemes to mitigate this environmental problem, such as the Clean Development Mechanism. Agroforestry systems with cacao are considered as mitigating activities of climate change due to their capture of carbon in biomass and necromass. The carbon storage and fixation in aboveground biomass and necromass in cacao plantations of 18 and 35 years in the Centro Universitario Regional del Norte (CURDN), in ArmeroGuayabal (Tolima, Colombia) were estimated. The studied cacao plantations stored 28.8 and 33.6 t C ha-1 in aboveground biomass with an age of 18 and 35 years respectively, showing an average fixation rate of 1.1 t C ha-1 year-1 . The stored carbon in necromass was 4.4 t ha-1 , with slight differences between the ages of plantations. Agroforestry systems with cacao in Armero-Guayabal, Tolima, Colombia have the potential to mitigate climate change due its capture of atmospheric carbon in aboveground biomass and necromass

Interplay between Structure-Specific Endonucleases for Crossover Control during Caenorhabditis elegans Meiosis

The number and distribution of crossover events are tightly regulated at prophase of meiosis I. The resolution of Holliday junctions by structure-specific endonucleases, including MUS-81, SLX-1, XPF-1 and GEN-1, is one of the main mechanisms proposed for crossover formation. However, how these nucleases coordinately resolve Holliday junctions is still unclear. Here we identify both the functional overlap and differences between these four nucleases regarding their roles in crossover formation and control in the Caenorhabditis elegans germline. We show that MUS-81, XPF-1 and SLX-1, but not GEN-1, can bind to HIM-18/SLX4, a key scaffold for nucleases. Analysis of synthetic mitotic defects revealed that MUS-81 and SLX-1, but not XPF-1 and GEN-1, have overlapping roles with the Bloom syndrome helicase ortholog, HIM-6, supporting their in vivo roles in processing recombination intermediates. Taking advantage of the ease of genetic analysis and high-resolution imaging afforded by C. elegans, we examined crossover designation, frequency, distribution and chromosomal morphology in single, double, triple and quadruple mutants of the structure-specific endonucleases. This revealed that XPF-1 functions redundantly with MUS-81 and SLX-1 in executing crossover formation during meiotic double-strand break repair. Analysis of crossover distribution revealed that SLX-1 is required for crossover suppression at the center region of the autosomes. Finally, analysis of chromosome morphology in oocytes at late meiosis I stages uncovered that SLX-1 and XPF-1 promote meiotic chromosomal stability by preventing formation of chromosomal abnormalities. We propose a model in which coordinate action between structure-specific nucleases at different chromosome domains, namely MUS-81, SLX-1 and XPF-1 at the arms and SLX-1 at the center region, exerts positive and negative regulatory roles, respectively, for crossover control during C. elegans meiosis

Activation of the maternal immune system alters cerebellar development in the offspring

A common pathological finding in autism is a localized deficit in Purkinje cells (PCs). Cerebellar abnormalities have also been reported in schizophrenia. Using a mouse model that exploits a known risk factor for these disorders, maternal infection, we asked if the offspring of pregnant mice given a mid-gestation respiratory infection have cerebellar pathology resembling that seen in these disorders. We also tested the effects of maternal immune activation in the absence of virus by injection of the synthetic dsRNA, poly(I:C). We infected pregnant mice with influenza on embryonic day 9.5 (E9.5), or injected poly(I:C) i.p. on E12.5, and assessed the linear density of PCs in the cerebellum of adult or postnatal day 11 (P11) offspring. To study granule cell migration, we also injected BrdU on P11. Adult offspring of influenza- or poly(I:C)-exposed mice display a localized deficit in PCs in lobule VII of the cerebellum, as do P11 offspring. Coincident with this are heterotopic PCs, as well as delayed migration of granule cells in lobules VI and VII. The cerebellar pathology observed in the offspring of influenza- or poly(I:C)-exposed mice is strikingly similar to that observed in autism. The poly(I:C) findings indicate that deficits are likely caused by the activation of the maternal immune system. Finally, our data suggest that cerebellar abnormalities occur during embryonic development, and may be an early deficit in autism and schizophrenia