Méthode de détection des antibiotiques dans les tissus animaux

Frères D., Valdebouze P., Jacquet . Méthode de détection des antibiotiques dans les tissus animaux. In: Bulletin de l'Académie Vétérinaire de France tome 122 n°8, 1969. pp. 847-853

BRCA1 germline mutation and glioblastoma development: report of cases

Background Germline mutations in breast cancer susceptibility gene 1 (BRCA1) increase the risk of breast and ovarian cancers. However, no association between BRCA1 germline mutation and glioblastoma malignancy has ever been highlighted. Here we report two cases of BRCA1 mutated patients who developed a glioblastoma (GBM). Cases presentation Two patients diagnosed with triple negative breast cancer (TNBC) were screened for BRCA1 germline mutation. They both carried a pathogenic mutation introducing a premature STOP codon in the exon 11 of the BRCA1 gene. Few years later, both patients developed a glioblastoma and a second breast cancer. In an attempt to clarify the role played by a mutated BRCA1 allele in the GBM development, we investigated the BRCA1 mRNA and protein expression in breast and glioblastoma tumours for both patients. The promoter methylation status of this gene was also tested by methylation specific PCR as BRCA1 expression is also known to be lost by this mechanism in some sporadic breast cancers. Conclusion Our data show that BRCA1 expression is maintained in glioblastoma at the protein and the mRNA levels, suggesting that loss of heterozygosity (LOH) did not occur in these cases. The protein expression is tenfold higher in the glioblastoma of patient 1 than in her first breast carcinoma, and twice higher in patient 2. In agreement with the high protein expression level in the GBM, BRCA1 promoter methylation was not observed in these tumours. In these two cases, despite of a BRCA1 pathogenic germline mutation, the tumour-suppressor protein expression is maintained in GBM, suggesting that the BRCA1 mutation is not instrumental for the GBM development

Exercices ortographique [ressource électronique] : cours de deuxième et troisiè me année mis en rapport avec la grammaire des Frères des écoles chrétiennes/

à l'usage des écoles des Frères des écoles chrétiennes."Livre de l'élève.""Les meilleurs méthodes sont celles qui font le plus agir l'esprit, ... --Mgr. Dupanlou."Reproduction électronique.Mode of access: Internet.Mode d'accès: World Wide Web.4

Recherche des résidus à activité antibiotique dans les tissus animaux. I. Mise au point d’une méthode de détection des antibiotiques dans le muscle

Frères D., Valdebouze P., Balland F., Jacquet Jean. Recherche des résidus à activité antibiotique dans les tissus animaux. I. Mise au point d’une méthode de détection des antibiotiques dans le muscle. In: Bulletin de l'Académie Vétérinaire de France tome 122 n°8, 1969. pp. 835-845