An Incentive System for Salmonella Control in the Pork Supply Chain

This paper presents a dynamic principal-agent analysis of an incentive system for Salmonella control in the pork supply chain. The incentive system determines quality premiums to the producer, testing frequencies for hogs delivered, as well as charges to the producer for testing and penalties. Using cost estimates and technical parameters, we evaluate the cost effectiveness of plant and farm control measures and trade-offs between prevalence reduction and related costs and gains. We also assess the impact of ownership structure on incentive system parameters and performance for a wide range of prevalence threshold levels. Differences in control actions, bacteriological prevalence and the overall welfare gain for the chain are very small across ownership structures. Changes in the prevalence threshold level lead to substantial changes in the use of farm and plant control packages and performance measures.dynamic programming, food quality, principal-agent, Food Consumption/Nutrition/Food Safety, Livestock Production/Industries,

Black Holes, Entropy Bound and Causality Violation

The gravity/gauge theory duality has provided us a way of studying QCD at short distances from straightforward calculations in classical general relativity. Among numerous results obtained so far, one of the most striking is the universality of the ratio of the shear viscosity to the entropy density. For all gauge theories with Einstein gravity dual, this ratio is \eta/s=1/4\pi. However, in general higher-curvature gravity theories, including two concrete models under discussion - the Gauss-Bonnet gravity and the (Riemann)^2 gravity - the ratio \eta/s can be smaller than 1/4\pi (thus violating the conjecture bound), equal to 1/4\pi or even larger than 1/4\pi. As we probe spacetime at shorter distances, there arises an internal inconsistency in the theory, such as a violation of microcausality, which is correlated with a classical limit on black hole entropy.Comment: 8 pages, no figures; Invited contribution to appear in the Proceedings of the 75 Years since Solvay, Singapore, Nov 2008, (World Scientific, Singapore, 2009

Do methanethiol adsorbates on the Au(111) surface dissociate?

The interaction of methanethiol molecules CH$_{3}$SH with the Au(111) surface is investigated, and it is found for the first time that the S-H bond remains intact when the methanethiol molecules are adsorbed on the regular Au(111) surface. However, it breaks if defects are present in the Au(111) surface. At low coverage, the fcc region is favored for S atom adsorption, but at saturated coverage the adsorption energies at various sites are almost iso-energetic. The presented calculations show that a methanethiol layer on the regular Au(111) surface does not dimerize.Comment: 4 pages, 2 figures, 4 tables, submitted to Phys. Rev. Let

Typing Quantum Superpositions and Measurement

We propose a way to unify two approaches of non-cloning in quantum lambda-calculi. The first approach is to forbid duplicating variables, while the second is to consider all lambda-terms as algebraic-linear functions. We illustrate this idea by defining a quantum extension of first-order simply-typed lambda-calculus, where the type is linear on superposition, while allows cloning base vectors. In addition, we provide an interpretation of the calculus where superposed types are interpreted as vector spaces and non-superposed types as their basis.Fil: Díaz Caro, Alejandro. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dowek, Gilles. Institut National de Recherche en Informatique et en Automatique; Franci

Increasing power for voxel-wise genome-wide association studies : the random field theory, least square kernel machines and fast permutation procedures

Imaging traits are thought to have more direct links to genetic variation than diagnostic measures based on cognitive or clinical assessments and provide a powerful substrate to examine the influence of genetics on human brains. Although imaging genetics has attracted growing attention and interest, most brain-wide genome-wide association studies focus on voxel-wise single-locus approaches, without taking advantage of the spatial information in images or combining the effect of multiple genetic variants. In this paper we present a fast implementation of voxel- and cluster-wise inferences based on the random field theory to fully use the spatial information in images. The approach is combined with a multi-locus model based on least square kernel machines to associate the joint effect of several single nucleotide polymorphisms (SNP) with imaging traits. A fast permutation procedure is also proposed which significantly reduces the number of permutations needed relative to the standard empirical method and provides accurate small p-value estimates based on parametric tail approximation. We explored the relation between 448,294 single nucleotide polymorphisms and 18,043 genes in 31,662 voxels of the entire brain across 740 elderly subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Structural MRI scans were analyzed using tensor-based morphometry (TBM) to compute 3D maps of regional brain volume differences compared to an average template image based on healthy elderly subjects. We find method to be more sensitive compared with voxel-wise single-locus approaches. A number of genes were identified as having significant associations with volumetric changes. The most associated gene was GRIN2B, which encodes the N-methyl-d-aspartate (NMDA) glutamate receptor NR2B subunit and affects both the parietal and temporal lobes in human brains. Its role in Alzheimer's disease has been widely acknowledged and studied, suggesting the validity of the approach. The various advantages over existing approaches indicate a great potential offered by this novel framework to detect genetic influences on human brains

Incidence of HI 21-cm absorption in strong FeII systems at 0.5<z<1.50.5<z<1.5

We present the results from our search for HI 21-cm absorption in a sample of 16 strong FeII systems ($W_{\rm r}$(MgII $\lambda2796$) $\ge1.0$ \AA\ and $W_{\rm r}$(FeII $\lambda2600$) or $W_{\rm FeII}$ $\ge1$ \AA) at $0.5<z<1.5$ using the Giant Metrewave Radio Telescope and the Green Bank Telescope. We report six new HI 21-cm absorption detections from our sample, which have increased the known number of detections in strong MgII systems at this redshift range by $\sim50$%. Combining our measurements with those in the literature, we find that the detection rate of HI 21-cm absorption increases with $W_{\rm FeII}$, being four times higher in systems with $W_{\rm FeII}$ $\ge1$ \AA\ compared to systems with $W_{\rm FeII}$ $<1$ \AA. The $N$(HI) associated with the HI 21-cm absorbers would be $\ge 2 \times 10^{20}$ cm$^{-2}$, assuming a spin temperature of $\sim500$ K (based on HI 21-cm absorption measurements of damped Lyman-$\alpha$ systems at this redshift range) and unit covering factor. We find that HI 21-cm absorption arises on an average in systems with stronger metal absorption. We also find that quasars with HI 21-cm absorption detected towards them have systematically higher $E(B-V)$ values than those which do not. Further, by comparing the velocity widths of HI 21-cm absorption lines detected in absorption- and galaxy-selected samples, we find that they show an increasing trend (significant at $3.8\sigma$) with redshift at $z<3.5$, which could imply that the absorption originates from more massive galaxy haloes at high-$z$. Increasing the number of HI 21-cm absorption detections at these redshifts is important to confirm various trends noted here with higher statistical significance.Comment: 17 pages, 10 figures, 8 tables, accepted for publication in MNRA

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated. We evaluated the effects of Gal-1 on eosinophil function and its role in a mouse model of allergic asthma. Allergen exposure resulted in airway recruitment of Gal-1-expressing inflammatory cells, including eosinophils, as well as increased Gal-1 in extracellular spaces in the lungs. In vitro, extracellular Gal-1 exerted divergent effects on eosinophils that were N-glycan- And dose-dependent. At concentrations ≤0.25 μM, Gal-1 increased eosinophil adhesion to vascular cell adhesion molecule-1, caused redistribution of integrin CD49d to the periphery and cell clustering, but inhibited ERK(1/2) activation and eotaxin-1-induced migration. Exposure to concentrations ≥1 μM resulted in ERK(1/2)- dependent apoptosis and disruption of the F- Actin cytoskeleton. At lower concentrations, Gal-1 did not alter expression of adhesion molecules (CD49d, CD18, CD11a, CD11b, L-selectin) or of the chemokine receptor CCR3, but decreased CD49d and CCR3 was observed in eosinophils treated with higher concentrations of this lectin. In vivo, allergen-challenged Gal-1-deficient mice exhibited increased recruitment of eosinophils and CD3+ T lymphocytes in the airways as well as elevated peripheral blood and bone marrow eosinophils relative to corresponding WT mice. Further, these mice had an increased propensity to develop airway hyperresponsiveness and displayed significantly elevated levels of TNF-α in lung tissue. This study suggests that Gal-1 can limit eosinophil recruitment to allergic airways and suppresses airway inflammation by inhibiting cell migration and promoting eosinophil apoptosis.Fil: Ge, Xiao Na. University of Minnesota; Estados UnidosFil: Ha, Sung Gil. University of Minnesota; Estados UnidosFil: Greenberg, Yana G.. University of Minnesota; Estados UnidosFil: Rao, Amrita. University of Minnesota; Estados UnidosFil: Bastan, Idil. University of Minnesota; Estados UnidosFil: Blidner, Ada Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rao, Savita P.. University of Minnesota; Estados UnidosFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sriramarao, P.. University of Minnesota; Estados Unido

Lattice-Driven Magnetoresistivity and Metal-Insulator Transition in Single-Layered Iridates

Sr2IrO4 exhibits a novel insulating state driven by spin-orbit interactions. We report two novel phenomena, namely a large magnetoresistivity in Sr2IrO4 that is extremely sensitive to the orientation of magnetic field but exhibits no apparent correlation with the magnetization, and a robust metallic state that is induced by dilute electron (La3+) or hole (K+) doping for Sr2+ ions in Sr2IrO4. Our structural, transport and magnetic data reveal that a strong spin-orbit interaction alters the balance between the competing energies so profoundly that (1) the spin degree of freedom alone is no longer a dominant force; (2) underlying transport properties delicately hinge on the Ir-O-Ir bond angle via a strong magnetoelastic coupling; and (3) a highly insulating state in Sr2IrO4 is proximate to a metallic state, and the transition is governed by lattice distortions. This work suggests that a novel class of lattice-driven electronic materials can be developed for applications.Comment: 4 figure