Mindfulness in psychiatry - Where are we now?

Mindfulness is an increasingly popular therapeutic approach. Mindfulness-based interventions have been tried out in a wide range of mental disorders, with the strongest evidence for use in depression and anxiety. Mindfulness operates by changing the person's relationship with unhelpful thoughts and emotions. The need for home practice is both a strength and a weakness. Some find home practice too demanding and a barrier to effective utilisation of mindfulness. Others discover a set of practical tools that, once learnt, can be applied to ongoing life difficulties; in this way mindfulness may have a place in promoting recovery beyond the acute treatment of a disorder. Additionally, mindfulness may be beneficial for clinicians to promote well-being and enhance the therapeutic relationship

The Limits of In-Run Calibration of MEMS Inertial Sensors and Sensor Arrays

MEMS accelerometers and gyroscope triads now cost less than $10, potentially opening up many new applications. However, these sensors require calibration prior to navigation use. This paper determines the maximum tolerable sensor errors for in-run calibration techniques using a basic Kalman filter by developing criteria for filter failure and performing Monte Carlo simulations for a range of different sensor specifications, and both car and UAV motion-profiles. Gyroscope bias is found to be the most significant with the maximum tolerable value of its SD varying between 0.75 and 2.6 deg/s depending on the value of the specification of the other sensor sources. The paper shows that pre-calibration and smart array techniques could potentially enable in-run calibration to be applied to lower-quality sensors. However, the estimation of scale-factor cross-coupling and gyroscope g-dependent errors could potentially be critical. Armed with this knowledge, designers can avoid both unnecessary design complexity and computational load of over-engineering and the poor navigation performance of inadequate filters

Reflection high-energy electron diffraction experimental analysis of polycrystalline MgO films with grain size and orientation distributions

Analysis of biaxial texture of MgO films grown by ion-beam-assisted deposition (IBAD) has been performed using a quantitative reflection high-energy electron diffraction (RHEED) based method. MgO biaxial texture is determined by analysis of diffraction spot shapes from single RHEED images, and by measuring the width of RHEED in-plane rocking curves for MgO films grown on amorphous Si3N4 by IBAD using 750 eV Ar+ ions, at 45° incidence angle, and MgO e-beam evaporation. RHEED-based biaxial texture measurement accuracy is verified by comparison with in-plane and out-of-plane orientation distribution measurements made using transmission electron microscopy and x-ray rocking curves. In situ RHEED measurements also enable the analysis of the evolution of the biaxial texture which narrows with increasing film thickness. RHEED-based measurements of IBAD MgO biaxial texture show that the minimum in-plane orientation distribution depends on the out-of-plane orientation distribution, and indicates that the minimum obtainable in-plane orientation on distribution is 2°

The role of Atonal transcription factors in the development of mechanosensitive cells

Mechanosensation is an evolutionarily ancient sensory modality seen in allmain animal groups. Mechanosensation can be mediated by sensory neurons or by dedicated receptor cells that form synapses with sensory neurons. Evidence over the last 15–20 years suggests that both classes of mechanosensory cells can be specified by the atonal class of basic helix-loop-helix transcription factors. In this review we discuss recent work addressing how atonal factors specify mechanosensitive cells in vertebrates and invertebrates, and how the redeployment of these factors underlies the regeneration of mechanosensitive cells in some vertebrate groups

Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome

Pneumococcal-associated hemolytic uremic syndrome (pHUS) is a rare but severe complication of invasive Streptococcus pneumoniae infection. We report the case of a 12-year-old female with steroid-resistant nephrotic syndrome treated with adrenocorticotrophic hormone (H.P. Acthar(®) Gel), who developed pneumococcal pneumonia and subsequent pHUS. While nephrotic syndrome is a well-known risk factor for invasive pneumococcal disease, this is the first reported case of pHUS in an adolescent patient with nephrotic syndrome, and reveals novel challenges in the diagnosis, treatment and potential prevention of this complication

Cohomological finiteness conditions for a class of metabelian groups

We consider a class of metabelian groups first studied by Baumslag and Stammbach and we show that these groups are consistent with the Bieri-Groves conjecture which relates cohomological finiteness conditions to the Bieri-Neumann-Strebel sigma invariant.Comment: 10 pages Accepted for publication in the Bulletin of the London Mathematical Societ

A Portfolio Approach to NLOS and Multipath Mitigation in Dense Urban Areas

Non-line-of-sight (NLOS) reception and multipath interference are major causes of poor GNSS positioning accuracy in dense urban environments. They are commonly grouped together. However, both the mechanisms by which they cause position errors and many of the techniques for mitigating those errors are quite different [1]. For example, correlation-based multipath mitigation has no effect on the errors caused by NLOS reception. University College London (UCL) has investigated the performance of a number of multipath and/or NLOS mitigation techniques in dense urban areas, including C/N0-based solution weighting [2], advanced consistency checking [3], dual-polarization NLOS detection [4] and vector tracking [5]. In this paper, we present a new multipath detection technique based on comparing the measured C/N0 on multiple frequencies and also new dual-polarization results. Meanwhile, other researchers have demonstrated NLOS detection using a panoramic camera [6, 7] or 3D city model [8, 9] and detection of NLOS and multipath using an antenna array [10]. All of these techniques bring some improvement in positioning performance in urban environments, but none of them eliminate the effects of both NLOS reception and multipath interference completely. As the different techniques are largely complementary, best performance is obtained by using several of them in combination, a portfolio approach. This paper comprises three parts. The first presents a feasibility study on a new multipath detection technique using multi-frequency C/N0 measurements. Constructive multipath interference results in an increase in the measured C/N0, whereas destructive multipath interference results in a decrease. As the phase of a reflected signal with respect to its directly received counterpart depends on the wavelength, the multipath interference may be constructive on one frequency and destructive on another. Thus, by comparing the difference in measured C/N0 between two frequencies with what would normally be expected for that signal at that elevation angle, strong multipath interference may be detected. However, the converse is not true because, depending on the path delay, the phase of the multipath interference may also be consistent across the two frequencies. Consistency across three frequencies in the presence of multipath interference is much less likely than consistency across two. Therefore, by comparing C/N0 measured across three (or more) frequencies, the chance of detection is improved substantially, noting that reliability is less critical as part of a portfolio approach to multipath detection than for a stand-alone technique. Experimental results are presented demonstrating the potential of this approach using GPS and GLONASS data collected in Central London. The second part of the paper presents the results of the first multi-constellation test of the dual-polarization NLOS detection technique pioneered at UCL [4]. This separately correlates the right hand circularly polarized (RHCP) and left hand circularly polarized (LHCP) outputs of a dual-polarization antenna and differences the resulting C/N0 measurements, producing a result that is positive for directly received signals and negative for most NLOS signals. Data was collected at six different sites in Central London and NLOS reception of both GPS and GLONASS signals was detected. Position solutions with the NLOS signals removed are compared with the corresponding all-satellite solutions. The final part of the paper addresses the portfolio approach to NLOS and multipath mitigation. Each technique is assessed qualitatively for its ease of implementation and its efficiency at detecting or directly mitigating both NLOS reception and multipath mitigation. A compatibility matrix is then presented showing which techniques may be combined without conflict. Suitable portfolios are then proposed both for professional-grade and for consumer-grade user equipment. References [1] Groves, P. D., Principles of GNSS, inertial, and multi-sensor integrated navigation systems, Second Edition, Artech House, 2013. [2] Jiang, Z., P. Groves, W. Y. Ochieng, S. Feng, C. D. Milner, and P. G. Mattos, “Multi-Constellation GNSS Multipath Mitigation Using Consistency Checking,” Proc. ION GNSS 2011. [3] Jiang, Z., and P. Groves, “GNSS NLOS and Multipath Error Mitigation using Advanced Multi-Constellation Consistency Checking with Height Aiding,” Proc. ION GNSS 2012. [4] Jiang, Z., and P. D. Groves, “NLOS GPS Signal Detection Using A Dual-Polarisation Antenna,” GPS Solutions, 2012, DOI: 10.1007/s10291-012-0305-5. [5] Hsu, L.-T., P. D. Groves, and S.-S. Jan, “Assessment of the Multipath Mitigation Effect of Vector Tracking in an Urban Environment,” Proc ION Pacific PNT, 2013. [6] Marais, J., M. Berbineau, and M. Heddebaut, “Land Mobile GNSS Availability and Multipath Evaluation Tool,” IEEE Transactions on Vehicular Technology, Vol. 54, No. 5, 2005, pp. 1697-1704. [7] Meguro, J., et al., “GPS Multipath Mitigation for Urban Area Using Omnidirectional Infrared Camera,” IEEE Transactions on Intelligent Transportation Systems, Vol. 10, No. 1, 2009, pp. 22-30. [8] Obst, M., S. Bauer, and G. Wanielik, “Urban Multipath Detection and mitigation with Dynamic 3D Maps for Reliable Land Vehicle Localization,” Proc. IEEE/ION PLANS 2012. [9] Peyraud, S., et al., “About Non-Line-Of-Sight Satellite Detection and Exclusion in a 3D Map-Aided Localization Algorithm,” Sensors, Vol. 13, 2013, pp. 829-847. [10] Keshvadi, M. H., A. Broumandan, and G. Lachapelle, “Analysis of GNSS Beamforming and Angle of Arrival Estimation in Multipath Environments," Proc ION ITM, San Diego, CA, January 2011, pp. 427-435