Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease

Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary disease remains unclear. We have investigated whether gene expression patterns in peripheral blood correlate with the severity of coronary disease and whether these patterns correlate with the extent of atherosclerosis in the vascular wall

Enhancement of Yield and Quality of Guava cv. Lucknow-49 by Foliar Application of Nutrients under High-Density Planting System

In view of the importance of foliar application of macro and micro nutrients to increase the yield and quality of guava under high density planting system, an experiment was laid out in a randomized complete block design consisting of nine treatment combinations with three replications. [(Control - Fertigation alone), (NPK (19:19:19)), (NPK + Zn), (NPK + Ca), (NPK + B), (NPK + Zn + Ca), (NPK + Zn + B), (NPK + Ca + B), (NPK + Zn + Ca + B). Among the treatments, fruit weight (225.22 g), fruit volume (215.35 ml),number of fruits per plant (80.35), fruit yield per plant(17.67 kg plant-1), TSS(10.60 0Brix), titratable acidity (0.196 %) and pectin content (1.31 %) was found to be significantly higher with the foliar application of NPK @ 1% + Zn @ 0.5 % + B @ 0.4%. The foliar spray of NPK @ 1% + Ca@ 0.2% + B@ 0.4% significantly increased the fruit diameter (7.85 cm), and ascorbic acid content (159.84 mg 100g-1). Thus, foliar spray of NPK, zinc and boron maintained more number of fruits per plant and improved the fruit set leading to an 18% increase in yield. Whereas, the addition of calcium to the plants increased the ascorbic acid content of the fruit and pectin that enhanced the shelf life of the fruit</jats:p

Intracranial Arteriovenous Malformations During Pregnancy and Puerperium-A Retrospective Nationwide Population-Based Cohort Study

BACKGROUND AND OBJECTIVES: The knowledge about the management of patients with brain arteriovenous malformations (AVM) during pregnancy is limited, owing partly to insufficient evidence about the outcomes of newborns. This study aims to explore symptomatic AVMs and their outcomes during pregnancy, delivery, and the postpartum period. METHODS: We conducted a retrospective analysis by combining patients with symptomatic AVM from a nationwide population-based cohort of all women with a pregnancy resulting in delivery during 1987 to 2016 (n = 1 773 728 deliveries) and our AVM database (n = 805, 1942-2014). Cerebrovascular events during pregnancy were identified through International Classification of Diseases-9, International Classification of Diseases-10, or surgical procedure codes from the Hospital Discharge and Medical Birth Registers. Our analysis focused on treatment characteristics and outcomes of patients with AVM hemorrhage or symptomatic AVM during pregnancy, delivery, or puerperium. RESULTS: A total of 28 women with symptomatic AVMs during pregnancy, delivery, or postpartum period were followed for an average of 12.8 years (SD = 15.5) after admission. Among them, 21 (75%) experienced AVM hemorrhages during pregnancy, puerperium, or delivery. The mean age of patients was 28.9 years (SD = 5.5). Hemorrhages occurred predominantly during the second (n = 9, 43% of all ruptures) or the third trimester (n = 5, 24%). Two AVM ruptures occurred during labor. Treatment for AVM took place during pregnancy (n = 7, 25%) or puerperium (n = 3, 14%) in 10 patients (35.7%). Only 5 mothers (17.8%) had not been previously pregnant. There was no significant difference in mean Apgar scores between those with AVM hemorrhage (8.3) and those without (8.4). CONCLUSION: Most mothers in the study had prior pregnancies, suggesting a potentially weaker association between AVM rupture and pregnancy compared to previous reports. Notably, 2 AVM ruptures occurred during spontaneous vaginal deliveries. Outcomes were generally favorable in both mothers and infants. More research is needed to refine our understanding of the optimal timing for invasive treatment during pregnancy.Peer reviewe