Stem cells conditioned medium: a new approach to skin wound healing management

Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine. Initially upon transplantation, these cells home to and differentiate within the injured tissue into specialised cells. Contrariwise, it now appears that only a small percentage of transplanted cells integrate and survive in host tissues. Thus, the foremost mechanism by which stem cells participate in tissue repair seems to be related to their trophic factors. Indeed, stem cells provide the microenvironment with a wide range of growth factors, cytokines and chemokines, which can broadly defined as the stem cells secretome. In in vitro condition, these molecules can be traced from the conditioned medium or spent media harvested from cultured cells. Conditioned medium now serves as a new treatment modality in regenerative medicine and has shown a successful outcome in some diseases. With the emergence of this approach, we described the possibility of using stem cells conditioned medium as a novel and promising alternative to skin wound healing treatment. Numerous pre-clinical data have shown the possibility and efficacy of this treatment. Despite this, significant challenges need to be addressed before translating this technology to the bedside.Article Link: http://onlinelibrary.wiley.com/doi/10.1002/cbin.10138/pd

Cross-Border Financing by the Industrial Sector Increases Competition in the Domestic Banking Sector

We predict that access to cross-border financing by the industrial sector reduces firms' reliance on domestic banks, thereby leading to lower rents for banks and greater competition in the domestic banking sector. We also predict that banks take on more risk to offset these lost rents and remain competitive. Using mandatory adoption of International Financial Reporting Standards (IFRS) to identify variation in cross-border financing, we find evidence consistent with our hypotheses. Additional tests verify that the effects emanate from the demand side (i.e., firms not relying on banks) rather than the supply side (i.e., banks not willing to lend to firms). Overall, we document how competition from overseas financial markets influences the domestic banking sector

Characterization of the domain chaos convection state by the largest Lyapunov exponent

Using numerical integrations of the Boussinesq equations in rotating cylindrical domains with realistic boundary conditions, we have computed the value of the largest Lyapunov exponent lambda1 for a variety of aspect ratios and driving strengths. We study in particular the domain chaos state, which bifurcates supercritically from the conducting fluid state and involves extended propagating fronts as well as point defects. We compare our results with those from Egolf et al., [Nature 404, 733 (2000)], who suggested that the value of lambda1 for the spiral defect chaos state of a convecting fluid was determined primarily by bursts of instability arising from short-lived, spatially localized dislocation nucleation events. We also show that the quantity lambda1 is not intensive for aspect ratios Gamma over the range 20<Gamma<40 and that the scaling exponent of lambda1 near onset is consistent with the value predicted by the amplitude equation formalism

High efficiency magnetic bearings

Research activities concerning high efficiency permanent magnet plus electromagnet (PM/EM) pancake magnetic bearings at the University of Maryland are reported. A description of the construction and working of the magnetic bearing is provided. Next, parameters needed to describe the bearing are explained. Then, methods developed for the design and testing of magnetic bearings are summarized. Finally, a new magnetic bearing which allows active torque control in the off axes directions is discussed

Sound Velocity Anomaly at the Mott Transition: application to organic conductors and V2O3

Close to the Mott transition, lattice degrees of freedom react to the softening of electron degrees of freedom. This results in a change of lattice spacing, a diverging compressibility and a critical anomaly of the sound velocity. These effects are investigated within a simple model, in the framework of dynamical mean-field theory. The results compare favorably to recent experiments on the layered organic \kappa-(BEDT-TTF)_2Cu[N(CN)_2]Cl conductor . We predict that effects of a similar magnitude are expected for V2O3, despite the much larger value of the elastic modulus of this material.Comment: New discussion of the relation between the sound-velocity and the compressibility has been adde

The origin and evolution of the zodiacal dust cloud

We have now analyzed a substantial fraction of the IRAS observations of the zodiacal cloud, particularly in the 25 micron waveband. We have developed a gravitational perturbation theory that incorporates the effects of Poynting-Robertson light drag (Gomes and Dermott, 1992). We have also developed a numerical model, the SIMUL mode, that reproduces the exact viewing geometry of the IRAS telescope and calculates the distribution of thermal flux produced by any particular distribution of dust particle orbits (Dermott and Nicholson, 1989). With these tools, and using a distribution of orbits based on those of asteroidal particles with 3.4 micron radii whose orbits decay due to Poynting-Robertson light drag and are perturbed by the planets, we have been able to: (1) account for the inclination and node of the background zodiacal cloud observed by IRAS in the 25 micron waveband; (2) relate the distribution of orbits in the Hirayama asteroid families to the observed shapes of the IRAS solar system dustbands; and (3) show that there is observational evidence in the IRAS data for the transport of asteroidal particles from the main belt to the Earth by Poynting-Robertson light drag

Historical and Projected Surface Temperature over India during the 20th and 21st century.

Surface Temperature (ST) over India has increased by ~0.055 K/decade during 1860-2005 and follows the global warming trend. Here, the natural and external forcings (e.g., natural and anthropogenic) responsible for ST variability are studied from Coupled Model Inter-comparison phase 5 (CMIP5) models during the 20th century and projections during the 21st century along with seasonal variability. Greenhouse Gases (GHG) and Land Use (LU) are the major factors that gave rise to warming during the 20th century. Anthropogenic Aerosols (AA) have slowed down the warming rate. The CMIP5 projection over India shows a sharp increase in ST under Representative Concentration Pathways (RCP) 8.5 where it reaches a maximum of 5 K by the end of the 21st century. Under RCP2.6 emission scenarios, ST increases up to the year 2050 and decreases afterwards. The seasonal variability of ST during the 21st century shows significant increase during summer. Analysis of rare heat and cold events for 2080-2099 relative to a base period of 1986-2006 under RCP8.5 scenarios reveals that both are likely to increase substantially. However, by controlling the regional AA and LU change in India, a reduction in further warming over India region might be achieved

Origin and evolution of the zodiacal dust cloud

The astrophysical importance of the zodiacal cloud became more apparent. The most useful source of information on the structure of the zodiacal cloud is the Infrared Astronomical Satellite (IRAS) observations. A substantial fraction of the extensive IRAS data set was analyzed. Also, a numerical model was developed (SIMUL) that allows to calculate the distribution of night-sky brightness that would be produced by any particular distribution of dust particle orbits. This model includes the effects of orbital perturbations by both the planets and solar radiation, it reproduces the exact viewing geometry of the IRAS telescope, and allows for the eccentricity of the Earth's orbit. SIMUL now is used to model not just the solar system dust bands discovered by IRAS but the whole zodiacal cloud