A Fragmentation study of di-acidic mycosporine-like amino acids in electrospray and nanospray mass spectrometry

Two mycosporine (MAAs), containing an extra acid function, were analyzed by nanospray and electrospray ionization tandem mass spectrometry. In contrast to the previous studies it is demonstrated that no significant characteristic methyl radical loss occurred in positive mode. The fragmentation pathway in negative mode was also proposed in this work, along with theoretical calculations to characterize the site of protonation.No presente estudo, duas micosporinas (MAAs) contendo um segundo ácido carboxílico foram submetidas à fragmentação em eletrospray e nanospray em diferentes equipamentos. Em contraste com resultados anteriores, a eliminação de radical metila no modo positivo de análise foi um processo minoritário de fragmentação. Neste trabalho apresentamos também a via de fragmentação destas substâncias em modo negativo e cálculos teóricos para caracterizar os sítios de protonação.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Mechanisms of Psychological Distress following War in the Former Yugoslavia: The Role of Interpersonal Sensitivity

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This study was funded by a grant from the European Commission, contract number INCO-CT-2004-509176. AN was supported by a Clinical Early Career Research Fellowship (113295) and a Project Grant (104288

Feasibility and reliability of PRISMA-Medical for specialty-based incident analysis

Aims and objectives: In this study, the feasibility and reliability of the Prevention Recovery Information System for Monitoring and Analysis (PRISMA)-Medical method for systematic, specialty-based analysis and classification of incidents in the neonatal intensive care unit (NICU) were determined. Methods: After the introduction of a Neonatology System for Analysis and Feedback on Medical Events (NEOSAFE) in eight tertiary care NICUs and one paediatric surgical ICU, PRISMA-Medical was started to be used to identify root causes of voluntary reported incidents by multidisciplinary unit patient safety committees. Committee members were PRISMA-trained and familiar with the department and its processes. In this study, the results of PRISMA-analysis of incidents reported during the first year are described. At t¿=¿3 months and t¿=¿12 months after introduction, test cases were performed to measure agreement at three levels of root cause classification using PRISMA-Medical. Inter-rater reliability was determined by calculating generalised ¿ values for each level of classification. Results: During the study period, 981 out of 1786 eligible incidents (55%) were analysed for underlying root causes. In total, 2313 root causes were identified and classified, giving an average of 2.4 root causes for every incident. Although substantial agreement (¿ 0.70–0.81) was reached at the main level of root cause classification of the test cases (discrimination between technical, organisational and human failure) and agreement among the committees at the second level (discrimination between skill-based, rule-based and knowledge-based errors) was acceptable (¿ 0.53–0.59), discrimination between rule-based errors (the third level of classification) was more difficult to assess (¿ 0.40–0.47). Conclusion: With some restraints, PRISMA-Medical proves to be both feasible and acceptably reliable to identify and classify multiple causes of medical events in the NICU

Unite and Unrule! Reflections of a co-created pedagogy for transformation

Reader notes • As a collective, we experimented with co-creation as means to develop a more creative, innovative and collaborative space in order to inspire (in)direct transformations in the larger HE system we study and work in. • Our approach to co-creation, as a specific form of collaboration, is inspired by insights from critical, contemplative, social justice and relational pedagogy based on design principles derived from regenerative development. • In this case study, we highlight two interrelated features of our co-creation approach to developing transgressive learning spaces: 1) relational learning beyond individualism, and 2) from competition towards reflective and self-directed learning

Unite and Unrule! Reflections of a co-created pedagogy for transformation

Reader notes • As a collective, we experimented with co-creation as means to develop a more creative, innovative and collaborative space in order to inspire (in)direct transformations in the larger HE system we study and work in. • Our approach to co-creation, as a specific form of collaboration, is inspired by insights from critical, contemplative, social justice and relational pedagogy based on design principles derived from regenerative development. • In this case study, we highlight two interrelated features of our co-creation approach to developing transgressive learning spaces: 1) relational learning beyond individualism, and 2) from competition towards reflective and self-directed learning

Specialty-based, voluntary incident reporting in neonatal intensive care: description of 4846 incident reports

OBJECTIVES: To examine the characteristics of incidents reported after introduction of a voluntary, non-punitive incident reporting system for neonatal intensive care units (NICUs) in the Netherlands; and to investigate which types of reported incident pose the highest risk to patients in the NICU. DESIGN: Prospective multicentre survey. METHODS: Voluntary, non-punitive incident reporting was introduced in eight level III NICUs and one paediatric surgical ICU. An incident was defined as any unintended event which (could have) reduced the safety margin for the patient. Multidisciplinary, unit-based patient safety committees systematically collected and analysed incident reports, and assigned risk scores to each reported incident. Data were centrally collected for specialty-based analysis. This paper describes the characteristics of incidents reported during the first year. Bivariate logistic regression analysis was conducted to identify high-risk incident categories. RESULTS: There were 5225 incident reports on 3859 admissions, of which 4846 were eligible for analysis. Incidents with medication were most frequently reported (27%), followed by laboratory (10%) and enteral nutrition (8%). Severe harm was described in seven incident reports, and moderate harm in 63 incident reports. Incidents involving mechanical ventilation and blood products were most likely to be assigned high-risk scores, followed by those involving parenteral nutrition, intravascular lines and medication dosing errors. CONCLUSIONS: Incidents occur much more frequently in Dutch NICUs than has been previously observed, and their impact on patient morbidity is considerable. Reported incidents concerning mechanical ventilation, blood products, intravascular lines, parenteral nutrition and medication dosing errors pose the highest risk to patients in the NIC

Fresh-blood-free diet for rearing malaria mosquito vectors

Mosquito breeding depends on the supply of fresh vertebrate blood, a major bottleneck for large-scale production of Anopheles spp. Feeding alternatives to fresh blood are thus a priority for research, outdoor large-cage trials and control interventions. Several artificial meal compositions were tested and Anopheles oogenesis, egg laying and development into the next generation of adult mosquitoes were followed. We identified blood-substitute-diets that supported ovarian development, egg maturation and fertility as well as, low progeny larval mortality, and normal development of offspring into adult mosquitoes. The formulated diet is an effective artificial meal, free of fresh blood that mimics a vertebrate blood meal and represents an important advance for the sustainability of Anopheles mosquito rearing in captivity.Agência financiadora / Número do subsídio Bill and Melinda Gates Foundation OPP1138841 Fundacao para a Ciencia e Tecnologia GHTM - UID/Multi/04413/201 CCMAR - UID/Multi/04326/2013 UID/Multi/04326/2013 RF SFRH/BPD/89811/2012 FAPEAM, Brazil 19716.UNI472.2459.20022014info:eu-repo/semantics/publishedVersio

Liquid metals as a divertor plasma facing material explored using the Pilot-PSI and Magnum-PSI linear devices

Abstract For DEMO and beyond liquid metal plasma facing components are considered due to their resilience to erosion through flowed replacement, potential for cooling beyond conduction and inherent immunity to many of the issues of neutron loading compared to solid materials. The development curve of liquid metals is behind that of e.g. tungsten however and tokamak-based research is currently somewhat limited in scope. Therefore investigation in linear plasma devices can provide faster progress under controlled and well-diagnosed conditions in assessing many of the issues surrounding the use of liquid metals. The linear plasma devices Magnum-PSI and Pilot-PSI are capable of producing DEMO relevant plasma fluxes which well replicate expected divertor conditions, and the exploration of physics issues for tin (Sn) and lithium (Li) such as vapour-shielding, erosion under high particle flux loading and overall power handing are reviewed here. A deeper understanding of erosion and deposition through this work indicates that stannane formation may play an important role in enhancing Sn erosion, while on the other hand the strong hydrogen isotope affinity reduces the evaporation rate and sputtering yields for Li. In combination with the strong re-deposition rates which have been observed under this type of high density plasma this implies an increase in the operational temperature range, implying a power handling range of 20-25 MW m -2 for Sn and up to 12.5 MW m -2 for Li could be achieved. Vapour shielding may be expected to act as a self-protection mechanism in reducing the heat load to the substrate for off-normal events in the case of Sn, but may potentially be a continual mode of operation for Li.</p

ANALISIS VERBA BERPREFIKS DENGAN VERBA DASAR KOMMEN DALAM BAHASA JERMAN

Verba merupakan suatu komponen yang mempunyai peranan penting dalam kalimat, karena verba digunakan untuk menyatakan tindakan (Handlungen), keadaan (Zustände) dan peristiwa (Vorgänge). Dalam bahasa Indonesia verba dapat dikombinasikan dengan imbuhan atau prefiks. Hal yang sama berlaku dalam bahasa Jerman. Akan tetapi berbeda dengan bahasa Indonesia, prefiks yang menyertai verba bahasa Jerman dapat mengubah makna dari verba dasarnya, seperti contoh verba kommen yang berarti ‘berasal’, ditambahkan prefiks ent- di awal verba, menjadi entkommen, maka maknanya berubah menjadi ‘melarikan diri’. Hal tersebut sangat penting untuk dipelajari dan dipahami oleh pembelajar. Berdasarkan hal tersebut peneliti tertarik untuk melakukan penelitian mengenai verba berprefiks dengan verba dasar kommen. Adapun tujuan penelitian ini adalah untuk mengetahui : 1) prefiks pada verba kommen, 2) jenis prefiks yang menyertai verba kommen berprefiks, dan 3) arti dari prefiks yang menyertai verba kommen berprefiks. Objek penelitian ini ialah verba kommen berprefiks yang terdapat dalam buku Tintenherz karya Cornelia Punke dan Majalah Brigitte terbitan 18 januari 2017. Adapun referensi yang digunakan untuk arti dari verba kommen berprefiks ialah Langenscheidt Groβwörterbuch Deutsch als Fremdsprache. Data yang ditemukan dalam penelitian ini adalah 47 kalimat dengan verba kommen berprefiks. Dari 47 kalimat tersebut ditemukan 12 macam verba kommen berprefiks, yaitu ankommen (3x), entkommen (4x), entgegenkommen (1x), heraufkommen (1x), herkommen (12x), mitkommen (7x), nachkommen (1x), vorbeikommen (3x), vorkommen (4x), wiederkommen (2x), zukommen (1x), dan zurückkommen (9x). Prefiks yang menyertai verba kommen terbagi menjadi dua jenis yaitu prefiks terikat dan tidak terikat, ada 9 macam prefiks yang masuk ke dalam jenis prefiks tidak terikat, dan 3 macam jenis prefiks terikat. Dari keseluruhan jumlah prefiks tersebut 2 macam prefiks memiliki arti lebih dari satu, yaitu prefiks her- dan vor-, sedangkan 10 prefiks lainnya yaitu prefiks an-, entgegen-, ent-, herauf-, mit-, nach-, vorbei-, wieder-, zu-, dan zurück- memiliki 1 arti. Berdasarkan hasil penelitian disarankan agar pembelajar dapat memperdalam prefiks melalui buku-buku gramatik dan membaca teks berbahasa Jerman berupa roman anak maupun artikel majalah. Adapun peneliti lain yang akan meneliti tentang prefiks disarankan untuk menggunakan referensi dan sumber data yang lebih banyak dan beragam. ABSTRAKT Verb ist ein Komponent, das eine wichtige Rolle in einem Satz spielt, da man ein Verb verwendet, um Handlungen, Zustände und Vorgänge zu bezeichnen. Im Indonesischen sind Verben mit Sufixen, Präfixen und so weiter kombinerbar. Das Phänomen gilt auch im Deutschen. Aber im Gegenteil zu Indonesisch kann das deutsche Präfix die Bedeutung von den Stammverben ändern, beispielweise, das Verb kommen heißt `berasal´ auf Indonesisch, aber wenn man zu dem Verb das Präfix ent- setzt, dann bedeutet das Verb ´melarikan diri´ auf Indonesisch. Solches linguistisches Phänomen ist sehr wichtig zu lernen und zu verstehen. In Bezug darauf interessiert sich die Verfasserin dafür, eine Untersuchung über die Analyse der Verben mit Präfixen am Beispiel vom Verb “kommen” im Deutschen durchzuführen. Diese Untersuchung hat den Zweck, folgende Punkte herauszufinden: 1) Präfixen vom Verb kommen; 2) die Arten von Präfixen vom Verb kommen; 3) die Bedeutung der Präfixe vom Verb kommen. Objekt dieser Untersuchung sind die Verben kommen mit Präfixen, die sich im Roman „Tintenherz“ von Cornelia Punke und in der Magazine „Brigitte“ befinden, die am 18. Januar 2017 erschienen. Als Quelle für die Bedeutungen der Verben kommen verwendet man das Langenscheidt Groβwörterbuch Deutsch als Fremdsprache. Die Ergebnisse der Untersuchung sind 47 Sätze mit Verb kommen mit Präfixen. In diesen 47 Sätzen wurden 12 Arten vom Verb kommen mit Präfixen gefunden. Sie sind nämlich, ankommen (3x), entkommen (4x), entgegenkommen (1x), heraufkommen (1x), herkommen (12x), mitkommen (7x), nachkommen (1x), vorbeikommen (3x), vorkommen (4x), wiederkommen (2x), zukommen (1x), und zurückkommen (9x). Die Präfixen bestehen aus zwei Arten, nämlich untrennbare und trennbare Präfixen. Es gibt 9 Präfixsorten, die zu den trennbaren Präfixen gehören und 3 Präfixsorten zu den untrennbaren Präfixen. Aus den Datenquellen werden 2 Präfixsorten gefunden, die zwei Bedeutungen haben. Sie sind Präfix her- und vor. Allerdings haben die 10 anderen Präfixe, namlich an-, entgegen-, ent-, herauf-, mit-, nach-, vorbei-, wieder-, zu-, und zurück-, nur eine Bedeutung. Basierend auf den Untersuchungsergebnissen sollten die Deutschlernenden mithilfe der grammatischen Bücher die Beherrschung von Präfixen vertiefen und Texte im Deutschen lesen, beispielsweise Kinderromane und Artikel in Magazinen. Darüber hinaus sollten andere weitere Untersucher in demselben Untersuchungsraum zahlreichere und vielfältige Referenzen und Datenquellen benutzen