A Presheaf Interpretation of the Generalized Freyd Conjecture

We give a generalized version of the Freyd conjecture and a way to think about a possible proof. The essential point is to describe an elementary formal reduction of the question that holds in any triangulated category. There are no new results, but at least one known example drops out quite trivially.Comment: 8 pages; formerly titled "Thinking about the Freyd conjecture

The construction, utilization, and evaluation of a series of exercises designed to improve the oral language of second grade children

Thesis (Ed.M.)--Boston Universit

Contrasting Experimentally Device-Manipulated and Device-Free Smiles.

Researchers in psychology have long been interested in not only studying smiles, but in examining the downstream effects of experimentally manipulated smiles. To experimentally manipulate smiles unobtrusively, participants typically hold devices (e.g., pens or chopsticks) in their mouths in a manner that activates the muscles involved in smiling. Surprisingly, despite decades of research using these methods, no study has tested to what degree these methods activate the same muscles as more natural, device-free smiles. Our study fills this gap in the literature by contrasting the magnitude of muscle activation in device-free smiles against the popular chopstick/pen manipulation. We also contrast these methods against the Smile Stick, a new device specifically designed to manipulate smiles in a comfortable and hygienic fashion. One hundred fifty-nine participants each participated in three facial expression manipulations that were held for 1 min: smile manipulation via Smile Stick, smile manipulation via chopsticks, and device-free smile. Facial electromyography was used to measure the intensity of the activation of the two main types of muscles involved in genuine, Duchenne smiling: the orbicularis oculi (a muscle group around the eyes) and the zygomaticus major (a muscle group in the cheeks). Furthermore, following each manipulation, participants rated their experience of the manipulation (i.e., comfort, fatigue, and difficulty), experienced affect (positive and negative), and levels of arousal. Results indicated that the Smile Stick and chopsticks performed equally across all measurements. Device-free smiles were rated as most comfortable but also the most fatiguing, and procured the greatest levels of positive affect and lowest levels of negative affect. Furthermore, device-free smiles resulted in significantly higher levels of both zygomaticus major (by ∼40%) and orbicularis oculi (by ∼15%) muscle activation than either the Smile Stick or chopsticks. The two devices were not different from each other in muscle activation. This study reveals that while device-free smiling procures the greatest changes in muscle activation and affect change, smiling muscle groups are activated by device manipulations, and expected changes in affect do occur, albeit to a lesser degree than device-free smiling. It also indicates that the Smile Stick is an acceptable and comparable alternative to disposable chopsticks

Effects of preconditioning and extrusion of linseed on the ruminal biohydrogenation of fatty acids. 2. In vitro and in situ studies

The extent and/or intermediates of ruminal biohydrogenation (BH) of fatty acids (FA) were investigated in vitro and in situ using a raw, pre-conditioned or extruded blend of linseed and wheat bran (70:30). The duration of in vitro incubations were 2, 4, 8, 16 and 24 h, with 5 replicates. In situ studies used 3 dry ruminally fistulated Holstein cows in a 3 × 3 Latin square design, with 3 weeks adaptation to the linseed form. The diet contained 20% (DM basis) of the linseed based blend. The duration of in situ incubations were 2, 4, 8, 16, 24 and 48 h. BH was much slower in situ than in vitro, resulting in a much lower effective disappearance of C18:2 and C18:3. Moreover, the in situ technique suggested that the technological pre-treatment of linseed did not affect C18:2 and C18:3 rate of BH, whereas reduced rates were observed in vitro. After 8 h of in vitro incubation and onwards, proportions of cis-9,trans-11C18:2 were the highest with extruded linseed. The BH of FA from linseed resulted in the appearance of great proportions of trans-10+11 to trans-16C18:1 intermediates. Extrusion increased the proportions of trans-10+11C18:1 both in vitro and in situ and proportions or trans-C18:1 were higher in situ than in vitro. Compared to previous in vivo results with the same material, the in situ method provided poor estimates of BH rates and intermediates

Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein.

BackgroundSleep disruptions occur early and frequently in Parkinson's disease (PD). PD patients also show a slowing of resting state activity. Alpha-synuclein is causally linked to PD and accumulates in sleep-related brain regions. While sleep problems occur in over 75% of PD patients and severely impact the quality of life of patients and caregivers, their study is limited by a paucity of adequate animal models.ObjectiveThe objective of this study was to determine whether overexpression of wildtype alpha-synuclein could lead to alterations in sleep patterns reminiscent of those observed in PD by measuring sleep/wake activity with rigorous quantitative methods in a well-characterized genetic mouse model.MethodsAt 10 months of age, mice expressing human wildtype alpha-synuclein under the Thy-1 promoter (Thy1-aSyn) and wildtype littermates underwent the subcutaneous implantation of a telemetry device (Data Sciences International) for the recording of electromyograms (EMG) and electroencephalograms (EEG) in freely moving animals. Surgeries and data collection were performed without knowledge of mouse genotype.ResultsThy1-aSyn mice showed increased non-rapid eye movement sleep during their quiescent phase, increased active wake during their active phase, and decreased rapid eye movement sleep over a 24-h period, as well as a shift in the density of their EEG power spectra toward lower frequencies with a significant decrease in gamma power during wakefulness.ConclusionsAlpha-synuclein overexpression in mice produces sleep disruptions and altered oscillatory EEG activity reminiscent of PD, and this model provides a novel platform to assess mechanisms and therapeutic strategies for sleep dysfunction in PD

GreenPhylDB: A Gene Family Database for plant functional Genomics

With the increasing number of genomes being sequenced, a major objective is to transfer accurate annotation from characterised proteins to uncharacterised sequences. Consequently, comparative genomics has become a usual and efficient strategy in functional genomics. The release of various annotated genomes of plants, such as _O. sativa_ and _A. thaliana_, has allowed setting up comprehensive lists of gene families defined by automated methods. However, like for gene sequence, manual curation of gene families is an important requirement that has to be undertaken. GreenPhylDB comprises protein sequences of 12 plant species fully sequenced that were grouped into homeomorphic families using similarity-based methods. Clusters are finally processed by phylogenetic analysis to infer orthologs and paralogs that will be particularly helpful to study genome evolution. Previously, each cluster has to be curated (i.e. properly named and classified) using different sources of information. A web interface for plant gene families’ curation was developed for that purpose. This interface, accessible on GreenPhylDB ("http://greenphyl.cirad.fr":http://greenphyl.cirad.fr), centralizes external references (e.g. InterPro, KEGG, Swiss-Prot, PIRSF, Pubmed) related to all gene members of the clusters and shows statistics and automatic analysis. We believe that this synthetic view of data available for a gene cluster, combined with basic guidelines, is an efficient way to provide reliable method for gene family annotations

The new pensions in Kazakhstan : challenges in making the transition

In June of 1997 Kazakhstan embarked on a dramatic reform of its pension system, replacing the inherited pay as you go regime with one based entirely on fully funded individual accounts. This paper provides projections of the effects of this reform on income replacement rates and considers some possible adjustments to the system design, including those enacted in early 2005, that could address the projected outcomes of the reform. The initial reform which did not include any minimum pension guarantee is projected to result in a significant reduction in the individual income replacement rates derived from the pension system, especially for women. When the reform was mature and the old system fully phased out, women are projected to have received pensions at level of less than 15 percent of their pre-retirement earnings. Various potential adjustments to the reform, including the recent introduction of a citizens pension or"demogrant", are found to have the capacity to significantly raise these income replacement rates. The fiscal costs of alternatives are found to vary considerably due significantly to the degree to which they would target expenditures to lower income groups. The analysis of the original reform design and possible adjustments provides some useful lessons about the design of individual account systems in transition economies.Pensions&Retirement Systems,State Owned Enterprise Reform,Economic Theory&Research,Gender and Law,Youth and Governance