Blood pressure, sensor development, atrial size measurement, and implant materials Progress report, 10 Apr. - 9 Jul. 1969

Research in medical science, University of Southern Californi

Observation of arterial blood pressure of the primate AAP-Bio-A-1 Quarterly progress report, 10 Jul. - 9 Oct. 1968

Circuits, components, and implant site evaluations for arterial blood pressure analyses on primate

Monitoring cardiovascular function in the primate under prolonged weightlessness

Monitoring cardiovascular function in primates under prolonged weightlessnes

Investigation to determine the effects of long-term bed rest on G-tolerance and on psychomotor performance Final report

Prolonged bed rest effects on gravity tolerance and psychomotor performance of human

A low power blood flow transmitter. Transmission of cardiovascular response to weightlessness Progress report, 1 Mar. - 31 May 1970

Low power blood flow transmitter to determine cardiovascular response to weightlessnes

Role of atrial receptors in the control of sodium excretion

Responses of an innervated and a contralateral chronically denervated kidney to mild positive pressure breathing are compared for saline volume expansions in chloralose anesthetized dogs. It is shown that mild pressure breathing significantly reduces sodium excretion, urine flow, free water clearance, and PAH clearance. After 20 minutes of positive pressure breathing, both kidney responses are identical suggesting the release of natriuretic hormone which reduces renal function in addition to the demonstrated change in renal nerve activity. Increase of the left atrial pressure through balloon obstruction of the mitral orifice increases urine flow, sodium excretion and PAH clearance; inflation of the balloon and positive pressure breathing again depresses renal function. Preliminary evidence indicates that receptors in the right atrium are more severely affected by pressure breathing than those in the left atrium

Wear transitions in a wear coefficient model

The frictional-work wear model has been used popularly for the prediction of wear phenomena such as rail corrugation. The accuracy of such models depends on the value chosen for the empirical wear coefficient in this wear model. Experimental results have widely shown that this wear coefficient is strongly dependent upon the type of wear process involved. The wear coefficient in the frictional-work wear model under two-disc contact and dry friction conditions proposed is a multi-step function of the friction power density corresponding to three types of wear. However, at present there is no clear means of predicting the transitions between wear types. This paper investigates wear transitions between the wear types are predicted using analytical models based on the wear mechanics involved

Implicit finite element study of non-steady effects in cold roll forming

The ability of ABAQUS Standard to obtain a non-steady implicit solution to the problem of cold roll forming a channel section is investigated. A solution can be found with careful selection of parameters, but solutions are unacceptably slow for commercial use. The implicit solutions show buckling on the first pass that does not develop into an edge wave, in contrast to a published explicit solution. Faster solutions to steady rolling can be obtained using ALE models that permit convection of stress in the direction of rolling

5-hydroxymethylcytosine profiling as an indicator of cellular state

A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer. J Thomson is supported by the MARCAR project. Work in RR Meehan’s laboratory is supported by the Medical Research Council, the BBSRC and by the Innovative Medicine Initiative Joint Undertaking (IMI JU) under grant agreement number 115001 (MARCAR project).DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydroxymethylcytosine and, with this, greater insight into the distribution, regulation and function of this mark, which are reviewed here. Better understanding of the associated pathways involved in regulation of, and by, 5-hydroxymethylcytosine may give promise to new therapeutic targets. We discuss evidence to support the view of 5-hydroxymethylcytosine as a unique and dynamic mark of cellular state. These 5-hydroxymethylcytosine profiles may offer optimism for the development of diagnostic, prognostic and predictive biomarkers.Peer reviewe

Probabilistic Prediction of Wheel Squeal under Field Humidity Variation

This research examines the effect of changes in coefficient of friction due to humidity on the likelihood of wheel squeal events occurring in practice. Theoretical mechanics based modeling is developed and compared to a database of field measurements of wheel squeal occurrences at a field site in Australia. In particular, a relatively simplified model of wheel squeal is developed based on existing literature but notably incorporates probabilistic mechanics to account for field parameter variations and hence allows direct comparisons with field data. The model is then tuned to field site conditions at which over 2 million wheel passes have been monitored for a period of 3 years. The comparison indicates that field measured trends for the effect of relative humidity on coefficient of friction and hence the occurrences of wheel squeal have been able to be predicted using the very efficient model