Clinical and biochemical improvements in a patient with MNGIE following enzyme replacement.

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive metabolic disorder caused by a deficiency of thymidine phosphorylase (TP, EC2.4.2.4) due to mutations in the nuclear gene TYMP. TP deficiency leads to plasma and tissue accumulations of thymidine and deoxyuridine which generate imbalances within the mitochondrial nucleotide pools, ultimately leading to mitochondrial dysfunction.1 MNGIE is characterized clinically by leukoencephalopathy, external ophthalmoplegia, peripheral polyneuropathy, cachexia, and enteric neuromyopathy manifesting as gastrointestinal dysmotility. The condition is relentlessly progressive, with patients usually dying from a combination of nutritional and neuromuscular failure at an average age of 37 years.2 Allogeneic hematopoietic stem cell transplantation (AHSCT) offers a permanent cure. Clinical and biochemical improvements following AHSCT have been reported but it carries a high mortality risk and is limited by matched donor availability.3 A consensus proposal for standardizing AHSCT recommends treatment of patients without irreversible end-stage disease and with an optimally matched donor; a majority of patients are ineligible and thus there is a critical requirement for an alternative treatment

A Twistor Formulation of the Non-Heterotic Superstring with Manifest Worldsheet Supersymmetry

We propose a new formulation of the $D=3$ type II superstring which is manifestly invariant under both target-space $N=2$ supersymmetry and worldsheet $N=(1,1)$ super reparametrizations. This gives rise to a set of twistor (commuting spinor) variables, which provide a solution to the two Virasoro constraints. The worldsheet supergravity fields are shown to play the r\^ole of auxiliary fields.Comment: 21p., LaTe

Free Differential Algebras and Pure Spinor Action in IIB Superstring Sigma Models

In this paper we extend to the case of IIB superstring sigma models the method proposed in hep-th/10023500 to derive the pure spinor approach for type IIA sigma models. In particular, starting from the (Free) Differential Algebra and superspace parametrization of type IIB supergravity, extended to include the BRST differential and all the ghosts, we derive the BRST transformations of fields and ghosts as well as the standard pure spinor constraints for the ghosts $\lambda$ related to supersymmetry. Moreover, using the method first proposed by us, we derive the pure spinor action for type IIB superstrings in curved supergravity backgrounds (on shell), in full agreement with the action first obtained by Berkovits and Howe.Comment: 24 page

Pure Spinor Approach to Type IIA Superstring Sigma Models and Free Differential Algebras

This paper considers the Free Differential Algebra and rheonomic parametrization of type IIA Supergravity, extended to include the BRS differential and the ghosts. We consider not only the ghosts lambda's of supersymmetry but also the ghosts corresponding to gauge and Lorentz transformations. In this way we can derive not only the BRS transformations of fields and ghosts but also the standard pure spinor constraints on lambda's. Moreover the formalism allows to derive the action for the pure spinor formulation of type IIA superstrings in a general background, recovering the action first obtained by Berkovits and Howe.Comment: 1+23 pages, v2: added clarifications and a reference, misprints corrected, v3: presentation improved, results unchange

On Lorentz Invariant Actions for Chiral P-Forms

We demonstrate how a Lorentz covariant formulation of the chiral p-form model in D=2(p+1) containing infinitely many auxiliary fields is related to a Lorentz covariant formulation with only one auxiliary scalar field entering a chiral p-form action in a nonpolynomial way. The latter can be regarded as a consistent Lorentz-covariant truncation of the former. We make the Hamiltonian analysis of the model based on the nonpolynomial action and show that the Dirac constraints have a simple form and are all of the first class. In contrast to the Siegel model the constraints are not the square of second-class constraints. The canonical Hamiltonian is quadratic and determines energy of a single chiral p-form. In the case of d=2 chiral scalars the constraint can be improved by use of `twisting' procedure (without the loss of the property to be of the first class) in such a way that the central charge of the quantum constraint algebra is zero. This points to possible absence of anomaly in an appropriate quantum version of the model.Comment: RevTeX file, 7 page

Superbrane Actions and Geometrical Approach

We review a generic structure of conventional (Nambu-Goto and Dirac-Born-Infeld-like) worldvolume actions for the superbranes and show how it is connected through a generalized action construction with a doubly supersymmetric geometrical approach to the description of super-p-brane dynamics as embedding world supersurfaces into target superspaces.Comment: Based on talks given by the authors at the Volkov Memorial Seminar "Supersymmetry and Quantum field Theory" (Kharkov, January 5-7, 1997), LaTeX file, 11 pages Misprints corrected, references adde

A twistor-like D=10 superparticle action with manifest N=8 world-line supersymmetry

We propose a new formulation of the $D=10$ Brink-Schwarz superparticle which is manifestly invariant under both the target-space super-Poincar\'e group and the world-line local $N=8$ superconformal group. This twistor-like construction naturally involves the sphere $S^8$ as a coset space of the $D=10$ Lorentz group. The action contains only a finite set of auxiliary fields, but they appear in unusual trilinear combinations. The origin of the on-shell $D=10$ fermionic $\kappa$ symmetry of the standard Brink-Schwarz formulation is explained. The coupling to a $D=10$ super-Maxwell background requires a new mechanism, in which the electric charge appears only on shell as an integration constant.Comment: 22pages, standard LATEX fil

Why Don't We Have a Covariant Superstring Field Theory?

This talk deals with the old problem of formulatingn a covariant quantum theory of superstrings, ``covariant'' here meaning having manifest Lorentz symmetry and supersymmetry. The advantages and disadvantages of several quantization methods are reviewed. Special emphasis is put on the approaches using twistorial variables, and the algebraic structures of these. Some unsolved problems are identified.Comment: 5 pages, Goteborg-ITP-94-24, plain te

Simplifying Algebra in Feynman Graphs, Part III: Massive Vectors

A T-dualized selfdual inspired formulation of massive vector fields coupled to arbitrary matter is generated; subsequently its perturbative series modeling a spontaneously broken gauge theory is analyzed. The new Feynman rules and external line factors are chirally minimized in the sense that only one type of spin index occurs in the rules. Several processes are examined in detail and the cross-sections formulated in this approach. A double line formulation of the Lorentz algebra for Feynman diagrams is produced in this formalism, similar to color ordering, which follows from a spin ordering of the Feynman rules. The new double line formalism leads to further minimization of gauge invariant scattering in perturbation theory. The dualized electroweak model is also generated.Comment: 39 pages, LaTeX, 8 figure

N=1 SUPER-P-BRANES in twistor-like Lorentz harmonic formulation

Unique twistor--like Lorentz harmonic formulation for all N=1 supersymmetric extended objects (super-p-branes) moving in the space--time of arbitrary dimension D (admissible for given $p$) are suggested. The equations of motion are derived, explicit form of the \kappa-symmetry transformations is presented and the classical equivalence to the standard formulation is proved. The cases with minimal world--sheet dimensions $p=1,2$, namely of D=10 heterotic string and D=11 supermembrane, are considered in details. In particular, the explicit form of irreducible \kappa-symmetry transformations for D=11 supermembrane is derived.Comment: (revized: minor changes, which was nesessary because previous version cannot be read LATEX byond Padova University), 24 pages, LATEX , DEPD/94/TH/3