New insights into the influence of ice on the coastal marine environment of the Beaufort Sea, Alaska

Areal patterns from field data and ERTS-1 imagery have shown a close relationship between geologic processes and the influence of sea ice along Alaska's northern coast, perhaps the nation's least known continental margin. Ice acts as; (1) a bottom-gouging agent; (2) an influence on water circulation; (3) a carrier of sediments; and (4) an influence on water types

Studies of the inner shelf and coastal sedimentation environment of the Beaufort Sea from ERTS-A

The author has identified the following significant results. Shearing periodically occurs between the westward moving pack ice (3 to 10 km/d) within the Pacific Gyre and the fast ice along the coast, forming major grounded shear and pressure ridges between the 10 to 40 m isobaths. Ridges occur in patterns conforming to known shoals. The zone of grounded ridges, called stamukhi zone, protects the inner shelf and coast from marine energy and pack ice forces. Relatively undeformed fast ice grows inshore of the stamukhi zone. The boundary is explained in terms of pack ice drift and major promontories and shoals. Intense ice gaging, highly disrupted sediments, and landward migration of shoals suggest that much of the available marine energy is expended on the sea floor within the stamukhi zone. Naleds (products of river icings) on the North Slope are more abundant east than west of the Colville River. Their location, growth, and decay were studied from LANDSAT imagery

East Siberian Arctic Region Expedition '92: The Laptev Sea - Its Significance for Arctic Sea-Ice Formation and Transpolar Sediment Flux

Darin enthalten: Expedition to Novaja Zemlja and Franz Josef Land with RV "Dalnie Zelentsy" / by D. Nürnberg and E. Groth, pp. 45-7

Моксифлоксацин (авелокс) в сравнении с комбинацией "офлоксацин плюс метронидазол" при неосложненных воспалительных заболеваниях органов малого таза. Результаты многоцентрового, двойного слепого, рандомизированного клинического исследования

ЖЕНСКИЕ БОЛЕЗНИ /ЛЕК ТЕРМОКСИФЛОКСАЦИНАВЕЛОКСОФЛОКСАЦИНМЕТРОНИДАЗО

Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study

This phase II, randomised, double-blind, multicentre study (NCT00930982) investigated the safety and efficacy of ciprofloxacin dry powder for inhalation (DPI) in patients with non-cystic fibrosis bronchiectasis. Adults who were culture positive for pre-defined potential respiratory pathogens (including Pseudomonas aeruginosa and Haemophilus influenzae) were randomised to ciprofloxacin DPI 32.5 mg or placebo administered twice daily for 28 days (with 56 days of follow-up). Bacterial density in sputum (primary end-point), pulmonary function tests, health-related quality of life and safety were monitored throughout the study. 60 subjects received ciprofloxacin DPI 32.5 mg and 64 received placebo. Subjects on ciprofloxacin DPI had a significant reduction (p<0.001) in total sputum bacterial load at the end of treatment (-3.62 log10 CFU·g(-1) (range -9.78-5.02 log10 CFU·g(-1))) compared with placebo (-0.27 log10 CFU·g(-1) (range -7.96-5.25 log10 CFU·g(-1))); the counts increased thereafter. In the ciprofloxacin DPI group, 14 (35%) out of 40 subjects reported pathogen eradication at end of treatment versus four (8%) out of 49 in the placebo group (p=0.001). No abnormal safety results were reported and rates of bronchospasm were low. Ciprofloxacin DPI 32.5 mg twice daily for 28 days was well tolerated and achieved significant reductions in total bacterial load compared with placebo in subjects with non-cystic fibrosis bronchiectasis.Robert Wilson, Tobias Welte, Eva Polverino, Anthony De Soyza, Hugh Greville, Anne O, Donnelle, Jeff Alder, Peter Reimnitz, and Barbara Hampe

Direct molecular versus culture-based assessment of Gram-positive cocci in biopsies of patients with major abscesses and diabetic foot infections

Major abscesses and diabetic foot infections (DFIs) are predominant subtypes of complicated skin and skin structure infections (cSSSIs), and are mainly caused by Staphylococcus aureus and β-hemolytic streptococci. This study evaluates the potential benefit of direct pathogen-specific real-time polymerase chain reaction (PCR) assays in the identification of causative organisms of cSSSIs. One-hundred and fifty major abscess and 128 DFI biopsy samples were collected and microbial DNA was extracted by using the Universal Microbe Detection kit for tissue samples. Pathogen-specific PCRs were developed for S. aureus and its virulence factor Panton–Valentine leukocidin (PVL), Streptococcus pyogenes, S. agalactiae, S. dysgalactiae, and the S. anginosus group. Identification by pathogen-specific PCRs was compared to routine culture and both methods were considered as the gold standard for determination of the sensitivity and specificity of each assay. Direct real-time PCR assays of biopsy samples resulted in a 34 % higher detection of S. aureus, 37 % highe

Assembly of Linked Nanocrystal Colloids by Reversible Covalent Bonds

The use of dynamically bonding molecules designed to reversibly link solvent-dispersed nanocrystals (NCs) is a promising strategy to form colloidal assemblies with controlled structure and macroscopic properties. In this work, tin-doped indium oxide NCs are functionalized with ligands that form reversible covalent bonds with linking molecules to drive assembly of NC gels. We monitor gelation using small angle X-ray scattering and characterize how changes in the gel structure affect infrared optical properties arising from the localized surface plasmon resonance of the NCs. The assembly is reversible because of the designed linking chemistry, and we disassemble the gels using two strategies: addition of excess NCs to change the ratio of linking molecules to NCs and addition of a capping molecule that displaces the linking molecules. The assembly behavior is rationalized using a thermodynamic perturbation theory to compute the phase diagram of the NC–linking molecule mixture. Coarse-grained molecular dynamics simulations reveal the competition between loop and bridge linking motifs essential for understanding NC gelation. This combined experimental, computational, and theoretical work provides a platform for controlling and designing the properties of reversible colloidal assemblies that incorporate NC and solvent compositions beyond those compatible with other contemporary (e.g, DNA-based) linking strategies.We would like to acknowledge the UT Mass Spectrometry Facility for their instrumental help and the UT NMR facilities for equipment use and assistance: NIH Grant Number 1 S10 OD021508-01. This work was primarily supported by the National Science Foundation through the Center for Dynamics and Control of Materials: an NSF Materials Research Science and Engineering Center (NSF MRSEC) under Cooperative Agreement DMR-1720595. This work was also supported by NSF Graduate Research Fellowships DGE-1610403 (M.N.D. and S.V.), an Arnold O. Beckman Postdoctoral Fellowship (Z.M.S.), NSF (CHE- 1905263), and the Welch Foundation (F-1848 and F-1696). E.V.A. acknowledges support from the Welch Regents Chair (F-0046). We acknowledge the Texas Advanced Computing Center (TACC) at The University of Texas at Austin for providing HPC resources.Center for Dynamics and Control of Material

Sea ice circulation in the Laptev Sea and ice export to the Arctic Ocean: Sea ice circulation in the Laptev Sea and ice export to the Arctic Ocean: Results from satellite remote sensing and numerical modeling

Sea ice circulation in the Laptev Sea and ice exchange with the Arctic Ocean have been studied based on remote sensing data and numerical modeling. Ice drift patterns for short‐ and long‐term periods were retrieved from successive Okean radar images and Special Sensor Microwave/Imager data for the winters 1987/1988 and 1994/1995. Seasonal and interannual variabilities of ice drift in the Laptev Sea and ice exchange with the Arctic Ocean during the period from 1979 to 1995 were studied with a large‐scale dynamic‐thermodynamic sea ice model. During an “average year,” sea ice was exported from the Laptev Sea through its northern and eastern boundaries, with maximum and minimum export occurring in February and August, respectively. The winter ice outflow from the Laptev Sea varied between 251,000 km2 (1984/1985) and 732,000 km2 (1988/1989) with the mean value of 483,000 km2. Sea ice was exported into the East Siberian Sea mostly in summers with the mean value of 69,000 km2. Out of the 17 investigated summers, 12 were characterized by sea ice import from the Arctic Ocean into the Laptev Sea through its northern boundary. Magnitude and direction of ice export from the Laptev Sea corresponded with the large‐scale Arctic Ocean drift patterns during periods of prevailing cyclonic or anticyclonic circulation. Based on a semiempirical method that has been validated with the large‐scale model and satellite data, ice exchange between the Laptev Sea and the Arctic Ocean during the period from 1936 to 1995 has been estimated as 309,000km2 with strong interannual variability and no significant trend apparent

Direct molecular versus culture-based assessment of Gram-positive cocci in biopsies of patients with major abscesses and diabetic foot infections

Contains fulltext : 155030.pdf (publisher's version ) (Open Access)Major abscesses and diabetic foot infections (DFIs) are predominant subtypes of complicated skin and skin structure infections (cSSSIs), and are mainly caused by Staphylococcus aureus and beta-hemolytic streptococci. This study evaluates the potential benefit of direct pathogen-specific real-time polymerase chain reaction (PCR) assays in the identification of causative organisms of cSSSIs. One-hundred and fifty major abscess and 128 DFI biopsy samples were collected and microbial DNA was extracted by using the Universal Microbe Detection kit for tissue samples. Pathogen-specific PCRs were developed for S. aureus and its virulence factor Panton-Valentine leukocidin (PVL), Streptococcus pyogenes, S. agalactiae, S. dysgalactiae, and the S. anginosus group. Identification by pathogen-specific PCRs was compared to routine culture and both methods were considered as the gold standard for determination of the sensitivity and specificity of each assay. Direct real-time PCR assays of biopsy samples resulted in a 34 % higher detection of S. aureus, 37 % higher detection of S. pyogenes, 18 % higher detection of S. agalactiae, 4 % higher detection of S. dysgalactiae subspecies equisimilis, and 7 % higher detection of the S. anginosus group, compared to routine bacterial culture. The presence of PVL was mainly confined to S. aureus isolated from major abscess but not DFI biopsy samples. In conclusion, our pathogen-specific real-time PCR assays had a higher yield than culture methods and could be an additional method for the detection of relevant causative pathogens in biopsies