A Note on Solid-State Maxwell Demon

Starting from 2002, at least two kinds of laboratory-testable, solid-state Maxwell demons have been proposed that utilize the electric field energy of an open-gap n-p junction and that seem to challenge the validity of the Second Law of Thermodynamics. In the present paper we present some arguments against the alleged functioning of such devices.Comment: 9 pages, 4 figures. Foundations of Physics, forthcoming. arXiv admin note: substantial text overlap with arXiv:1101.505

The endocannabinoid/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss

Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determined the distribution of CB2R in the mouse and rat cochleae and examined whether these receptors provide protection against cisplatin-induced hearing loss. In a knock-in mouse model expressing the CB2R tagged with green fluorescent protein, we show distribution of CB2R in the organ of Corti, stria vascularis, spiral ligament and spiral ganglion cells. A similar distribution of CB2R was observed in the rat cochlea using a polyclonal antibody against CB2R. Trans-tympanic administration of (2-methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone (JWH015), a selective agonist of the CB2R, protected against cisplatin-induced hearing loss which was reversed by blockade of this receptor with 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone (AM630), an antagonist of CB2R. JWH015 also reduced the loss of outer hair cells (OHCs) in the organ of Corti, loss of inner hair cell (IHC) ribbon synapses and loss of Na+/K+-ATPase immunoreactivity in the stria vascularis. Administration of AM630 alone produced significant hearing loss (measured by auditory brainstem responses) which was not associated with loss of OHCs, but led to reductions in the levels of IHC ribbon synapses and strial Na+/K+-ATPase immunoreactivity. Furthermore, knock-down of CB2R by trans-tympanic administration of siRNA sensitized the cochlea to cisplatin-induced hearing loss at the low and middle frequencies. Hearing loss induced by cisplatin and AM630 in the rat was associated with increased expression of genes for oxidative stress and inflammatory proteins in the rat cochlea. In vitro studies indicate that JWH015 did not alter cisplatin-induced killing of cancer cells suggesting this agent could be safely used during cisplatin chemotherapy. These data unmask a protective role of the cochlear endocannabinoid/CB2R system which appears tonically active under normal conditions to preserve normal hearing. However, an exogenous agonist is needed to boost the activity of endocannabinoid/CB2R system for protection against a more traumatic cochlear insult, as observed with cisplatin administration.</p

J D Bernal: philosophy, politics and the science of science

This paper is an examination of the philosophical and political legacy of John Desmond Bernal. It addresses the evidence of an emerging consensus on Bernal based on the recent biography of Bernal by Andrew Brown and the reviews it has received. It takes issue with this view of Bernal, which tends to be admiring of his scientific contribution, bemused by his sexuality, condescending to his philosophy and hostile to his politics. This article is a critical defence of his philosophical and political position

J D Bernal: philosophy, politics and the science of science

This paper is an examination of the philosophical and political legacy of John Desmond Bernal. It addresses the evidence of an emerging consensus on Bernal based on the recent biography of Bernal by Andrew Brown and the reviews it has received. It takes issue with this view of Bernal, which tends to be admiring of his scientific contribution, bemused by his sexuality, condescending to his philosophy and hostile to his politics. This article is a critical defence of his philosophical and political position

Periodic Optical Variability of Radio Detected Ultracool Dwarfs

A fraction of very low mass stars and brown dwarfs are known to be radio active, in some cases producing periodic pulses. Extensive studies of two such objects have also revealed optical periodic variability and the nature of this variability remains unclear. Here we report on multi-epoch optical photometric monitoring of six radio detected dwarfs, spanning the $\sim$M8 - L3.5 spectral range, conducted to investigate the ubiquity of periodic optical variability in radio detected ultracool dwarfs. This survey is the most sensitive ground-based study carried out to date in search of periodic optical variability from late-type dwarfs, where we obtained 250 hours of monitoring, delivering photometric precision as low as $\sim$0.15%. Five of the six targets exhibit clear periodicity, in all cases likely associated with the rotation period of the dwarf, with a marginal detection found for the sixth. Our data points to a likely association between radio and optical periodic variability in late-M/early-L dwarfs, although the underlying physical cause of this correlation remains unclear. In one case, we have multiple epochs of monitoring of the archetype of pulsing radio dwarfs, the M9 TVLM 513-46546, spanning a period of 5 years, which is sufficiently stable in phase to allow us to establish a period of 1.95958 $\pm$ 0.00005 hours. This phase stability may be associated with a large-scale stable magnetic field, further strengthening the correlation between radio activity and periodic optical variability. Finally, we find a tentative spin-orbit alignment of one component of the very low mass binary LP 349-25.Comment: Accepted to The Astrophysical Journal; 22 pages; 12 figure

The psychological contract of knowledge workers

Purpose: This paper explores whether the concept of psychological contracts underpinned by relational/transactional exchanges provides an adequate description of knowledge workers’ contracts. Methodology: The research approach uses interviews with 10 scientists from within a pre-eminent Australian scientific research and development organisation, the Commonwealth Scientific & Industrial Research Organisation (CSIRO). Findings: The research strong evidence of an ideological currency within the psychological contract for this set of knowledge workers. Implications: The research raises questions over the role of normative occupation-specific beliefs about work, and the sharing of common currency elements by individuals in the same organization within the same occupation. The analysis lends support to calls in the literature for a reconsideration of the transactional/relational interpretative framework that underpins the psychological contract

A VLA Survey For Faint Compact Radio Sources in the Orion Nebula Cluster

We present Karl G. Janksy Very Large Array (VLA) 1.3 cm, 3.6 cm, and 6 cm continuum maps of compact radio sources in the Orion Nebular Cluster. We mosaicked 34 square arcminutes at 1.3 cm, 70 square arcminutes at 3.6 cm and 109 square arcminutes at 6 cm, containing 778 near-infrared detected YSOs and 190 HST-identified proplyds (with significant overlap between those characterizations). We detected radio emission from 175 compact radio sources in the ONC, including 26 sources that were detected for the first time at these wavelengths. For each detected source we fit a simple free-free and dust emission model to characterize the radio emission. We extrapolate the free-free emission spectrum model for each source to ALMA bands to illustrate how these measurements could be used to correctly measure protoplanetary disk dust masses from sub-millimeter flux measurements. Finally, we compare the fluxes measured in this survey with previously measured fluxes for our targets, as well as four separate epochs of 1.3 cm data, to search for and quantify variability of our sources.Comment: 13 pages, 6 figures, 4 tables, ApJ, in pres