Failure of specific active immunotherapy in lung cancer.

A randomized trial comparing routine follow-up with a treatment regimen aimed at increasing specific anti-tumour immunity has been carried out in 95 patients after total surgical excision of lung cancer (not small-cell). Treatment consisted of inoculation with an autologous irradiated suspension of tumour cells combined with a small dose of C. parvum given intradermally during convalescence. Although treatment was associated with virtually no side effects, there has been no apparent benefit and input to the trial has now stopped

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

The 2015-2017 excavations at Chalcolithic site of Chlorakas-Palloures on Cyprus

From 2015 to 2017 the first three excavation seasons took place at Chlorakas-Palloures, a Chalcolithic site in western Cyprus. Here we present the site stratigraphy, and the structures and burials, excavated at the site. We also introduce the ground stone, figurines and chipped stone found during these first seasons. We also introduce the ground stone, figurines, and chipped stone found during these first seasons. We discuss the raw materials used, the formal and informal tool types, and the context in which these objects were found, as well as how they fit into the broader knowledge of the period. Finally we present the faunal evidence. The aim is to provide colleagues with a first assessment of our results rather than a final report. Not all our assemblages have been fully processed, and inevitably our interpretations of the site and its assemblages will change in future seasons, as we excavate additional trenches and analyse further assemblages. Nonetheless we feel that our data are providing a siginificant addition to our knowledge of Chalcolithic Cyprus that should therefore be published in this interim report.Archaeology of the Near East and the Mediterranea

Polycystic ovary syndrome

The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.Polycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM) - with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer. PCOS is a diagnosis of exclusion, based primarily on the presence of hyperandrogenism, ovulatory dysfunction and PCOM. Treatment should be tailored to the complaints and needs of the patient and involves targeting metabolic abnormalities through lifestyle changes, medication and potentially surgery for the prevention and management of excess weight, androgen suppression and/or blockade, endometrial protection, reproductive therapy and the detection and treatment of psychological features. This Primer summarizes the current state of knowledge regarding the epidemiology, mechanisms and pathophysiology, diagnosis, screening and prevention, management and future investigational directions of the disorder.Robert J Norman, Ruijin Wu and Marcin T Stankiewic

Excavations at Chlorakas-Palloures, New Light on Chalcolithic Cyprus

Archaeology of the Near Eas

The ISLE corpus of non-native spoken English

For the purpose of developing pronunciation training tools for second language learning a corpus of non-native speech data has been collected, which consists of almost 18 hours of annotated speech signals spoken by Italian and German learners of English. The corpus is based on 250 utterances selected from typical second language learning exercises. It has been annotated at the word and the phone level, to highlight pronunciation errors such as phone realisation problems and misplaced word stress assignments. The data has been used to develop and evaluate several diagnostic components, which can be used to produce corrective feedback of unprecedented detail to a language learner