Patients First:Toward a Patient-Centered Instrument to Measure Impact of Chronic Pain

Background. Numerous instruments are available to measure the impact of chronic pain, yet most have been developed with little or no patient involvement. This study seeks to start bridging that gap by determining which health aspects or attributes (to be included in a future instrument) are considered most important by people with chronic pain. Objective. The goal of this study was to reveal which attributes reflecting impact of chronic pain are considered most important by people with chronic pain and to analyze differences in importance according to gender, age categories, diagnostic subgroups, and pain intensity categories. Design. This study used a sequential explanatory mixed-methods design: literature search, focus group meetings, and online survey. Methods. First, a literature search was performed to identify the attributes in existing instruments. In 68 instruments meeting inclusion criteria, 155 unique attributes were identified, 85 of which remained after applying the exclusion criteria. Second, 2 focus group meetings, with 6 and 4 patients, respectively, were held to verify that no attributes had been missed. Three attributes were subsequently added. Third, individuals with chronic pain were then sent an online survey through several patient organizations. Results. A total of 939 patients were asked to select the 8 attributes they deemed most important, which resulted in the following list: fatigue, social life, cramped muscles, sleeping, housekeeping, concentration, not being understood, and control over pain. The importance assigned to these 8 attributes varied slightly according to age, gender, and diagnostic subgroup. Limitations. Participation rate could not be established because of the online survey. Conclusions. Attributes reflecting impact of chronic pain deemed most important by patients are revealed. Importance of impact differs according to subgroups. The "patients-first" methodology used here revealed attributes that were not comprehensively covered in currently available instruments for measuring the impact of chronic pain

Formal change impact analyses for emulated control software

Processor emulators are a software tool for allowing legacy computer programs to be executed on a modern processor. In the past emulators have been used in trivial applications such as maintenance of video games. Now, however, processor emulation is being applied to safety-critical control systems, including military avionics. These applications demand utmost guarantees of correctness, but no verification techniques exist for proving that an emulated system preserves the original system’s functional and timing properties. Here we show how this can be done by combining concepts previously used for reasoning about real-time program compilation, coupled with an understanding of the new and old software architectures. In particular, we show how both the old and new systems can be given a common semantics, thus allowing their behaviours to be compared directly

Numerical Solution of Hard-Core Mixtures

We study the equilibrium phase diagram of binary mixtures of hard spheres as well as of parallel hard cubes. A superior cluster algorithm allows us to establish and to access the demixed phase for both systems and to investigate the subtle interplay between short-range depletion and long-range demixing.Comment: 4 pages, 2 figure

Dynamic Arc-Flags in Road Networks

International audienceIn this work we introduce a new data structure, named Road-Signs, which allows us to efficiently update the Arc-Flags of a graph in a dynamic scenario. Road-Signs can be used to compute Arc-Flags, can be efficiently updated and do not require large space consumption for many real-world graphs like, e.g., graphs arising from road networks. In detail, we define an algorithm to preprocess Road-Signs and an algorithm to update them each time that a weight increase operation occurs on an edge of the network. We also experimentally analyze the proposed algorithms in real-world road networks showing that they yields a significant speed-up in the updating phase of Arc-Flags, at the cost of a very small space and time overhead in the preprocessing phase

A coil-globule transition of a semiflexible polymer driven by the addition of spherical particles

The phase behaviour of a single large semiflexible polymer immersed in a suspension of spherical particles is studied. All interactions are simple excluded volume interactions and the diameter of the spherical particles is an order of magnitude larger than the diameter of the polymer. The spherical particles induce a quite long ranged depletion attraction between the segments of the polymer and this induces a continuous coil-globule transition in the polymer. This behaviour gives an indication of the condensing effect of macromolecular crowding on DNA.Comment: 12 pages, 4 figure

Galaxy Counterparts of metal-rich Damped Lyman-alpha Absorbers - I: The case of the z=2.35 DLA towards Q2222-0946

We have initiated a survey using the newly commissioned X-shooter spectrograph to target candidate relatively metal-rich damped Lyman-alpha absorbers (DLAs). The spectral coverage of X-shooter allows us to search for not only Lyman-alpha emission, but also rest-frame optical emission lines. We have chosen DLAs where the strongest rest-frame optical lines ([OII], [OIII], Hbeta and Halpha) fall in the NIR atmospheric transmission bands. In this first paper resulting from the survey, we report on the discovery of the galaxy counterpart of the z_abs = 2.354 DLA towards the z=2.926 quasar Q2222$-0946. This DLA is amongst the most metal-rich z>2 DLAs studied so far at comparable redshifts and there is evidence for substantial depletion of refractory elements onto dust grains. We measure metallicities from ZnII, SiII, NiII, MnII and FeII of -0.46+/-0.07, -0.51+/-0.06, -0.85+/-0.06, -1.23+/-0.06, and -0.99+/-0.06, respectively. The galaxy is detected in the Lyman-alpha, [OIII] lambda4959,5007 Halpha emission lines at an impact parameter of about 0.8 arcsec (6 kpc at z_abs = 2.354). We infer a star-formation rate of 10 M_sun yr^-1, which is a lower limit due to the possibility of slit-loss. Compared to the recently determined Halpha luminosity function for z=2.2 galaxies the DLA-galaxy counterpart has a luminosity of L~0.1L^*_Halpha. The emission-line ratios are 4.0 (Lyalpha/Halpha) and 1.2 ([OIII]/Halpha). The Lyalpha line shows clear evidence for resonant scattering effects, namely an asymmetric, redshifted (relative to the systemic redshift) component and a much weaker blueshifted component. The fact that the blueshifted component is relatively weak indicates the presence of a galactic wind. The properties of the galaxy counterpart of this DLA is consistent with the prediction that metal-rich DLAs are associated with the most luminous of the DLA-galaxy counterparts.Comment: 9 pages, 7 figures. Accepted for publication in MNRA

On the dependence between UV luminosity and Lyman-alpha equivalent width in high redshift galaxies

We show that with the simple assumption of no correlation between the Ly-alpha equivalent width and the UV luminosity of a galaxy, the observed distribution of high redshift galaxies in an equivalent width - absolute UV magnitude plane can be reproduced. We further show that there is no dependence between Ly-alpha equivalent width and Ly-alpha luminosity in a sample of Ly-alpha emitters. The test was expanded to Lyman-break galaxies and again no dependence was found. Simultaneously, we show that a recently proposed lack of large equivalent width, UV bright galaxies (Ando et al. 2006) can be explained by a simple observational effect, based on too small survey volumes.Comment: 7 pages, 3 figures, 2 tables, accepted in MNRA

Phase behaviour of additive binary mixtures in the limit of infinite asymmetry

We provide an exact mapping between the density functional of a binary mixture and that of the effective one-component fluid in the limit of infinite asymmetry. The fluid of parallel hard cubes is thus mapped onto that of parallel adhesive hard cubes. Its phase behaviour reveals that demixing of a very asymmetric mixture can only occur between a solvent-rich fluid and a permeated large particle solid or between two large particle solids with different packing fractions. Comparing with hard spheres mixtures we conclude that the phase behaviour of very asymmetric hard-particle mixtures can be determined from that of the large component interacting via an adhesive-like potential.Comment: Full rewriting of the paper (also new title). 4 pages, LaTeX, uses revtex, multicol, epsfig, and amstex style files, to appear in Phys. Rev. E (Rapid Comm.

On the sizes of z>2 Damped Lyman-alpha Absorbing Galaxies

Recently, the number of detected galaxy counterparts of z > 2 Damped Lyman-alpha Absorbers in QSO spectra has increased substantially so that we today have a sample of 10 detections. M{\o}ller et al. in 2004 made the prediction, based on a hint of a luminosity-metallicity relation for DLAs, that HI size should increase with increasing metallicity. In this paper we investigate the distribution of impact parameter and metallicity that would result from the correlation between galaxy size and metallicity. We compare our observations with simulated data sets given the relation of size and metallicity. The observed sample presented here supports the metallicity-size prediction: The present sample of DLA galaxies is consistent with the model distribution. Our data also show a strong relation between impact parameter and column density of HI. We furthermore compare the observations with several numerical simulations and demonstrate that the observations support a scenario where the relation between size and metallicity is driven by feedback mechanisms controlling the star-formation efficiency and outflow of enriched gas.Comment: Accepted for publishing in MNRAS lette