MUSE-inspired view of the quasar Q2059-360, its Lyman alpha blob, and its neighborhood

The radio-quiet quasar Q2059-360 at redshift $z=3.08$ is known to be close to a small Lyman $\alpha$ blob (LAB) and to be absorbed by a proximate damped Ly$\alpha$ (PDLA) system. Here, we present the Multi Unit Spectroscopic Explorer (MUSE) integral field spectroscopy follow-up of this quasi-stellar object (QSO). Our primary goal is to characterize this LAB in detail by mapping it both spatially and spectrally using the Ly$\alpha$ line, and by looking for high-ionization lines to constrain the emission mechanism. Combining the high sensitivity of the MUSE integral field spectrograph mounted on the Yepun telescope at ESO-VLT with the natural coronagraph provided by the PDLA, we map the LAB down to the QSO position, after robust subtraction of QSO light in the spectral domain. In addition to confirming earlier results for the small bright component of the LAB, we unveil a faint filamentary emission protruding to the south over about 80 pkpc (physical kpc); this results in a total size of about 120 pkpc. We derive the velocity field of the LAB (assuming no transfer effects) and map the Ly$\alpha$ line width. Upper limits are set to the flux of the N V $\lambda 1238-1242$, C IV $\lambda 1548-1551$, He II $\lambda 1640$, and C III] $\lambda 1548-1551$ lines. We have discovered two probable Ly$\alpha$ emitters at the same redshift as the LAB and at projected distances of 265 kpc and 207 kpc from the QSO; their Ly$\alpha$ luminosities might well be enhanced by the QSO radiation. We also find an emission line galaxy at $z=0.33$ near the line of sight to the QSO. This LAB shares the same general characteristics as the 17 others surrounding radio-quiet QSOs presented previously. However, there are indications that it may be centered on the PDLA galaxy rather than on the QSO.Comment: Accepted for publication in Astronomy & Astrophysics; 16 pages, 19 figure

Galaxy Counterparts of metal-rich Damped Lyman-alpha Absorbers - I: The case of the z=2.35 DLA towards Q2222-0946

We have initiated a survey using the newly commissioned X-shooter spectrograph to target candidate relatively metal-rich damped Lyman-alpha absorbers (DLAs). The spectral coverage of X-shooter allows us to search for not only Lyman-alpha emission, but also rest-frame optical emission lines. We have chosen DLAs where the strongest rest-frame optical lines ([OII], [OIII], Hbeta and Halpha) fall in the NIR atmospheric transmission bands. In this first paper resulting from the survey, we report on the discovery of the galaxy counterpart of the z_abs = 2.354 DLA towards the z=2.926 quasar Q2222$-0946. This DLA is amongst the most metal-rich z>2 DLAs studied so far at comparable redshifts and there is evidence for substantial depletion of refractory elements onto dust grains. We measure metallicities from ZnII, SiII, NiII, MnII and FeII of -0.46+/-0.07, -0.51+/-0.06, -0.85+/-0.06, -1.23+/-0.06, and -0.99+/-0.06, respectively. The galaxy is detected in the Lyman-alpha, [OIII] lambda4959,5007 Halpha emission lines at an impact parameter of about 0.8 arcsec (6 kpc at z_abs = 2.354). We infer a star-formation rate of 10 M_sun yr^-1, which is a lower limit due to the possibility of slit-loss. Compared to the recently determined Halpha luminosity function for z=2.2 galaxies the DLA-galaxy counterpart has a luminosity of L~0.1L^*_Halpha. The emission-line ratios are 4.0 (Lyalpha/Halpha) and 1.2 ([OIII]/Halpha). The Lyalpha line shows clear evidence for resonant scattering effects, namely an asymmetric, redshifted (relative to the systemic redshift) component and a much weaker blueshifted component. The fact that the blueshifted component is relatively weak indicates the presence of a galactic wind. The properties of the galaxy counterpart of this DLA is consistent with the prediction that metal-rich DLAs are associated with the most luminous of the DLA-galaxy counterparts.Comment: 9 pages, 7 figures. Accepted for publication in MNRA

The Great Observatories Origins Deep Survey - VLT/VIMOS Spectroscopy in the GOODS-South Field: Part II

We present the full data set of the VIMOS spectroscopic campaign of the ESO/GOODS program in the CDFS, which complements the FORS2 ESO/GOODS spectroscopic campaign. The GOODS/VIMOS spectroscopic campaign is structured in two separate surveys using two different VIMOS grisms. The VIMOS Low Resolution Blue (LR-Blue) and Medium Resolution (MR) orange grisms have been used to cover different redshift ranges. The LR-Blue campaign is aimed at observing galaxies mainly at 1.8<z<3.5, while the MR campaign mainly aims at galaxies at z<1 and Lyman Break Galaxies (LBGs) at z>3.5. The full GOODS/VIMOS spectroscopic campaign consists of 20 VIMOS masks. This release adds 8 new masks to the previous release (12 masks, Popesso et al. 2009). In total we obtained 5052 spectra, 3634 from the 10 LR-Blue masks and 1418 from the 10 MR masks. A significant fraction of the extracted spectra comes from serendipitously observed sources: ~21% in the LR-Blue and ~16% in the MR masks. We obtained 2242 redshifts in the LR-Blue campaign and 976 in the MR campaign for a total success rate of 62% and 69% respectively, which increases to 66% and 73% if only primary targets are considered. The typical redshift uncertainty is estimated to be ~0.0012 (~255 km/s) for the LR-Blue grism and ~0.00040 (~120 km/s) for the MR grism. By complementing our VIMOS spectroscopic catalog with all existing spectroscopic redshifts publicly available in the CDFS, we compiled a redshift master catalog with 7332 entries, which we used to investigate large scale structures out to z~3.7. We produced stacked spectra of LBGs in a few bins of equivalent width (EW) of the Ly-alpha and found evidence for a lack of bright LBGs with high EW of the Ly-alpha. Finally, we obtained new redshifts for 12 X-ray sources of the CDFS and extended-CDFS.Comment: 22 pages, 20 figures, accepted for publication on Astronomy and Astrophysics, catalogs and data products are available at http://archive.eso.org/cms/eso-data/data-packages/goods-vimos-spectroscopy-data-release-version-2.0/, for ESO-GOODS related material consult http://www.eso.org/sci/activities/projects/goods

Hypertension in older patients, a retrospective cohort study

Background: It is unknown to what extent General Practitioners (GPs) manage hypertension (HT) differently in older patients, as compared to younger age groups. The purpose of our study was to compare HT management in older patients to younger age groups. Methods: We performed a retrospective cohort study of patients of 159 GP's practices in the Integrated Primary Care Information (IPCI) database. The study period lasted from September 2010 through December 2012. The study population consisted of all patients aged 60 years or older with at least one blood pressure (BP) measurement during the inclusion period, without pre-existent HT, diabetes mellitus (DM) or atherosclerotic cardiovascular disease at time of study start. Study outcomes were a diagnosis of HT within one month after cohort entry and the use of antihypertensive medication within 4 months after cohort entry in HT diagnosed patients. We compared the incidence of outcomes between the age groups, stratified by systolic blood pressure (SBP). Logistic regression analysis was used to assess the influence of age-adjusted SBP Z-scores, age and gender on the outcomes. Results: We included 19,500 patients from 159 GP's practices of whom 1,181 (6.1 %) were newly diagnosed with HT. Corrected for age-adjusted SBP, older patients were less likely to be diagnosed with HT (odds ratio per year age increase 0.98, p < 0.001). Corrected for age-adjusted SBP, no significant effect of age on the probability of treatment in newly diagnosed HT patients was observed (p = 0.82). Conclusions: This study showed that GPs are less inclined to diagnose HT with increasing patient age, but do not withhold treatment when they diagnose HT in older patients

Discovery of a compact gas-rich DLA galaxy at z = 2.2: evidences for a starburst-driven outflow

We present the detection of Ly-alpha, [OIII] and H-alpha emission associated with an extremely strong DLA system (N(HI) = 10^22.10 cm^-2) at z=2.207 towards the quasar SDSS J113520-001053. This is the largest HI column density ever measured along a QSO line of sight, though typical of what is seen in GRB-DLAs. This absorption system also classifies as ultrastrong MgII system with W2796_r=3.6 A. The mean metallicity of the gas ([Zn/H]=-1.1) and dust depletion factors ([Zn/Fe]=0.72, [Zn/Cr]=0.49) are consistent with (and only marginally larger than) the mean values found in the general QSO-DLA population. The [OIII]-Ha emitting region has a very small impact parameter with respect to the QSO line of sight, b=0.1", and is unresolved. From the Ha line, we measure SFR=25 Msun/yr. The Ly-a line is double-peaked and is spatially extended. More strikingly, the blue and red Ly-a peaks arise from distinct regions extended over a few kpc on either side of the star-forming region. We propose that this is the consequence of Ly-a transfer in outflowing gas. The presence of starburst-driven outflows is also in agreement with the large SFR together with a small size and low mass of the galaxy (Mvir~10^10 Msun). From the stellar UV continuum luminosity of the galaxy, we estimate an age of at most a few 10^7 yr, again consistent with a recent starburst scenario. We interpret the data as the observation of a young, gas rich, compact starburst galaxy, from which material is expelled through collimated winds powered by the vigorous star formation activity. We substantiate this picture by modelling the radiative transfer of Ly-a photons in the galactic counterpart. Though our model (a spherical galaxy with bipolar outflowing jets) is a simplistic representation of the true gas distribution and velocity field, the agreement between the observed and simulated properties is particularly good. [abridged]Comment: 15 pages, 18 figures, 4 tables, accepted for publication in Astronomy and Astrophysic

The physical properties of Lyalpha emitting galaxies: not just primeval galaxies?

We have analyzed a sample of LBGs from z =3.5 to z=6 selected from the GOODS-S field as B,V and i-dropouts, and with spectroscopic observations showing that they have the Lyalpha line in emission. Our main aim is to investigate their physical properties and their dependence on the emission line characteristics, to shed light on the relation between galaxies with Lyalpha emission and the general LBG population.The objects were selected from their continuum colors and then spectroscopically confirmed by the GOODS collaboration and other campaigns. From the spectra we derived the line flux and EW. We then used U-band to mid-IR photometry from GOODS-MUSIC to derive the physical properties of the galaxies, such as total stellar mass, age and so on, through standard SED fitting techniques.Although most galaxies are fit by young stellar populations, a small but non negligible fraction has SEDs that require considerably older stellar component, up to 1 Gyr. There is no apparent relation between age and EW: some of the oldest galaxies have large EW, and should be also selected in narrow band surveys. Therefore not all Lyalpha emitters are primeval galaxies in the very early stages of formation,as is commonly assumed. We also find a large range of stellar populations, with masses from 5x10^8 Msol to 5x10^10 Msol and SFR from few to 60 Msol/yr. Although there is no correlation between mass and EW, we find a significant lack of massive galaxies with high EW, which could be explained if the most massive galaxies were more dusty and/or contained more neutral gas than less massive objects. Finally we find that more than half of the galaxies contain small but non negligible amounts of dust: the mean E(B-V) and the EW are well correlated, although with a large scatter, as already found at lower redshiftComment: Accepted by Astronomy & Astrophysci

Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction

Hypertension, obesity, and old age are major risk factors for left ventricular (LV) diastolic dysfunction (LVDD), but easily applicable screening tools for people at risk are lacking. We investigated whether HF1, a urinary biomarker consisting of 85 peptides, can predict over a 5-year time span mildly impaired diastolic LV function as assessed by echocardiography. In 645 white Flemish (50.5% women; 50.9 years [mean]), we measured HF1 by capillary electrophoresis coupled with mass spectrometry in 2005-2010. We measured early (E) and late (A) peak velocities of the transmitral blood flow and early (e') and late (a') mitral annular peak velocities and their ratios in 2009-2013. In multivariable-adjusted analyses, per 1-standard deviation increment in HF1, e' was -0.193 cm/s lower (95% confidence interval: -0.352 to -0.033; P = .018) and E/e' 0.174 units higher (0.005-0.342; P = .043). Of 645 participants, 179 (27.8%) had LVDD at follow-up, based on impaired relaxation in 69 patients (38.5%) or an elevated filling pressure in the presence of a normal (74 [43.8%]) or low (36 [20.1%]) age-specific E/A ratio. For a 1-standard deviation increment in HF1, the adjusted odds ratio was 1.37 (confidence interval, 1.07-1.76; P = .013). The integrated discrimination (+1.14%) and net reclassification (+31.7%) improvement of the optimized HF1 threshold (-0.350) in discriminating normal from abnormal diastolic LV function at follow-up over and beyond other risk factors was significant (P ≤ .024). In conclusion, HF1 may allow screening for LVDD over a 5-year horizon in asymptomatic people

The unusual NIV]-emitter galaxy GDS J033218.92-275302.7: star formation or AGN-driven winds from a massive galaxy at z=5.56

Aims: We investigate the nature of the source GDS J033218.92-275302.7at redshift ~ 5.56. Methods: The SED of the source is well sampled by 16 bands photometry, from UV-optical, near infrared and mid-infrared (MID-IR).The detection of signal in the MID-IR Spitzer/IRAC bands 5.8, 8.0 um -- where the nebular emission contribution is less effective -- suggests the presence of a Balmer break, signature of an underlying stellar population formed at earlier epochs. The optical spectrum shows a clear Lya emission line together with semi-forbidden NIV] 1483.3-1486.5 also in emission. Results: From the SED fitting and the Lya modelling it turns out that the source seems to have an evolved component with stellar mass of ~5 x10^(10) Msolar and age ~ 0.4 Gyrs, and a young component with an age of ~ 0.01 Gyrs and SFR in the range of 30-200 Msolar yr^(-1). The limits on the effective radius derived from the ACS/z850 and VLT/Ks bands indicate that this galaxy is denser than the local ones with similar mass. A relatively high nebular gas column density is favored from the Lya line modelling (NHI>=10^(21) cm^(-2)). A vigorous outflow (~ 450 km/s) has been measured from the optical spectrum,consistent with the Lya modelling. From ACS observations it turns out that the region emitting Lya photons is spatially compact and of the same order of the effective radius estimated at the ~1400A rest-frame wavelength, whose emission is dominated by the stellar continuum and/or AGN. The gas is blown out from the central region,but given the mass of the galaxy it is uncertain whether it will pollute the IGM to large distances. We argue that a burst of star formation in a dense gas environment is active (possibly containing hot and massive stars and/or a low luminosity AGN), superimposed to an already formed fraction of stellar mass (abridged).Comment: 13 pages, 9 figures (published on A&A). Here replaced with a typo fixed in the footnote of Sect. 4.2 and with four updated references. Results unchange

Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats

Background The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Methods Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or 18 weeks (late diabetic, with or without insulin 3 units per day), and age-matched healthy controls. Left sciatic nerve block was performed using 0.2 ml lidocaine 2%. Nerve conduction velocity (NCV) and F-wave latency were used to quantify nerve function before, and 1 week after nerve block, after which sciatic nerves were used for neurohistopathology. Results Early diabetic animals did not show increased signs of nerve dysfunction after nerve block. In late diabetic animals without insulin vs control animals, NCV was 34.8 (5.0) vs 41.1 (4.1) ms s−1 (P<0.01), and F-wave latency was 7.7 (0.5) vs 7.0 (0.2) ms (P<0.01), respectively. Motor nerve block duration was prolonged in late diabetic animals, but neurotoxicity was not. Late diabetic animals receiving insulin showed intermediate results. Conclusions In a rodent type II DM model, nerves have increased sensitivity for short-acting local anaesthetics without adjuvants in vivo, as evidenced by prolonged block duration. This sensitivity appears to increase with the progression of neuropathy. Our results do not support the hypothesis that neuropathy due to type II DM increases the risk of nerve injury after nerve bloc

Keck Spectroscopy of Faint 3<z<7 Lyman Break Galaxies: - I. New constraints on cosmic reionisation from the luminosity and redshift-dependent fraction of Lyman-alpha emission

We present results from a new Keck spectroscopic survey of UV-faint LBGs in the redshift range 3<z<7. Combined with earlier Keck and published ESO VLT data, our sample contains more than 600 dropouts, offering new insight into the nature of sub-L* sources typical of those likely to dominate the cosmic reionisation process. Here we use this sample to characterise the fraction of strong Lya emitters within the continuum-selected dropouts. By quantifying how the "Lya fraction" varies with redshift, we seek to constrain changes in Lya transmission associated with reionisation. In order to distinguish the effects of reionisation from other factors which affect the Lya fraction (e.g. dust, ISM kinematics), we study the luminosity and redshift-dependence of the Lya fraction over 3<z<6, when the IGM is known to be ionised. These results reveal that low luminosity galaxies show strong Lya emission much more frequently than luminous systems, and that at fixed luminosity, the prevalence of strong Lya emission increases moderately with redshift over 3 < z < 6. Based on the correlation between blue UV slopes and strong Lya emitting galaxies in our dataset, we argue that the Lya fraction trends are governed by redshift and luminosity-dependent variations in the dust obscuration, with likely additional contributions from trends in the kinematics and covering fraction of neutral hydrogen. We find a tentative decrease in the Lya fraction at z~7 based on the limited IR spectra for candidate z~7 lensed LBGs, a result which, if confirmed with future surveys, would suggest an increase in the neutral fraction by this epoch. Given the supply of z and Y-drops now available from Hubble WFC3/IR surveys, we show it will soon be possible to significantly improve estimates of the Lya fraction using optical and near-IR spectrographs, thereby extending the study conducted in this paper to 7<z<8.Comment: 23 pages, 15 figures, submitted to MNRA