2,378 research outputs found
Target Estimation in Colocated MIMO Radar via Matrix Completion
We consider a colocated MIMO radar scenario, in which the receive antennas
forward their measurements to a fusion center. Based on the received data, the
fusion center formulates a matrix which is then used for target parameter
estimation. When the receive antennas sample the target returns at Nyquist
rate, and assuming that there are more receive antennas than targets, the data
matrix at the fusion center is low-rank. When each receive antenna sends to the
fusion center only a small number of samples, along with the sample index, the
receive data matrix has missing elements, corresponding to the samples that
were not forwarded. Under certain conditions, matrix completion techniques can
be applied to recover the full receive data matrix, which can then be used in
conjunction with array processing techniques, e.g., MUSIC, to obtain target
information. Numerical results indicate that good target recovery can be
achieved with occupancy of the receive data matrix as low as 50%.Comment: 5 pages, ICASSP 201
Dual-acting stapled peptides target both HIV-1 entry and assembly
Background:
Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD) of the HIV-1 capsid (CA) protein with an improved affinity (Kd ~ 1 μM) compared to CAI (Kd ~ 15 μM). NYAD-1 disrupts the formation of both immature- and mature-like virus particles in in vitro and cell-based assembly assays. In addition, it displays potent anti-HIV-1 activity in cell culture against a range of laboratory-adapted and primary HIV-1 isolates.<p></p>
Results:
In this report, we expanded the study to i,i + 7 hydrocarbon-stapled peptides to delineate their mechanism of action and antiviral activity. We identified three potent inhibitors, NYAD-36, -66 and -67, which showed strong binding to CA in NMR and isothermal titration calorimetry (ITC) studies and disrupted the formation of mature-like particles. They showed typical α-helical structures and penetrated cells; however, the cell penetration was not as efficient as observed with the i,i + 4 peptides. Unlike NYAD-1, the i,i + 7 peptides did not have any effect on virus release; however, they impaired Gag precursor processing. HIV-1 particles produced in the presence of these peptides displayed impaired infectivity. Consistent with an effect on virus entry, selection for viral resistance led to the emergence of two mutations in the gp120 subunit of the viral envelope (Env) glycoprotein, V120Q and A327P, located in the conserved region 1 (C1) and the base of the V3 loop, respectively.<p></p>
Conclusion:
The i,i + 7 stapled peptides derived from CAI unexpectedly target both CA and the V3 loop of gp120. This dual-targeted activity is dependent on their ability to penetrate cells as well as their net charge. This mechanistic revelation will be useful in further modifying these peptides as potent anti-HIV-1 agents.<p></p>
Energy Content of Colliding Plane Waves using Approximate Noether Symmetries
This paper is devoted to study the energy content of colliding plane waves
using approximate Noether symmetries. For this purpose, we use approximate Lie
symmetry method of Lagrangian for differential equations. We formulate the
first-order perturbed Lagrangian for colliding plane electromagnetic and
gravitational waves. It is shown that in both cases, there does not existComment: 18 pages, accepted for publication in Brazilian J Physic
Measurement of the CKM Matrix Element from at Belle
We present a new measurement of the CKM matrix element from decays, reconstructed with the full Belle data set
of integrated luminosity. Two form factor
parameterizations, originally conceived by the Caprini-Lellouch-Neubert (CLN)
and the Boyd, Grinstein and Lebed (BGL) groups, are used to extract the product
and the decay form factors, where
is the normalization factor and is a small
electroweak correction. In the CLN parameterization we find
, , , . For the BGL parameterization we
obtain , which is consistent with the World Average when correcting for
. The branching fraction of is measured to be . We also present a new
test of lepton flavor universality violation in semileptonic decays,
. The errors correspond to the statistical and
systematic uncertainties respectively. This is the most precise measurement of
and form factors to date and the first
experimental study of the BGL form factor parameterization in an experimental
measurement
Randomised trials of 6 % tetrastarch (hydroxyethyl starch 130/0.4 or 0.42) for severe sepsis reporting mortality: systematic review and meta-analysis.
Angular analysis of
We present a measurement of angular observables, , , ,
, in the decay , where
is either or . The analysis is performed on
a data sample corresponding to an integrated luminosity of
containing pairs, collected
at the resonance with the Belle detector at the
asymmetric-energy collider KEKB. Four angular observables,
are extracted in five bins of the invariant mass squared of the
lepton system, . We compare our results for with Standard
Model predictions including the region in which the LHCb collaboration
reported the so-called anomaly.Comment: Conference paper for LHC Ski 2016. SM prediction for
corrected and reference for arXiv:1207.2753 adde
Search for violation in the decay at Belle
We search for violation in the charged charm meson decay
, based on a data sample corresponding to an integrated
luminosity of collected by the Belle experiment at the KEKB
asymmetric-energy collider. The measured violating asymmetry
is , which is consistent with
the standard model prediction and has a significantly improved precision
compared to previous results.Comment: 8 pages, 3 figure
Measurement of Branching Fractions of Hadronic Decays of the Baryon
Using a data sample of 980 of annihilation data
taken with the Belle detector operating at the KEKB asymmetric-energy
collider, we report the results of a study of the decays of the
charmed baryon into hadronic final states. We report the most precise
measurements to date of the relative branching fractions of the
into , , , and
, as well as the first measurements of the branching fractions
of the into , , and , all with respect to the decay. In
addition, we investigate the resonant substructure of these modes. Finally, we
present a limit on the branching fraction for the decay
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