2,378 research outputs found

    Target Estimation in Colocated MIMO Radar via Matrix Completion

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    We consider a colocated MIMO radar scenario, in which the receive antennas forward their measurements to a fusion center. Based on the received data, the fusion center formulates a matrix which is then used for target parameter estimation. When the receive antennas sample the target returns at Nyquist rate, and assuming that there are more receive antennas than targets, the data matrix at the fusion center is low-rank. When each receive antenna sends to the fusion center only a small number of samples, along with the sample index, the receive data matrix has missing elements, corresponding to the samples that were not forwarded. Under certain conditions, matrix completion techniques can be applied to recover the full receive data matrix, which can then be used in conjunction with array processing techniques, e.g., MUSIC, to obtain target information. Numerical results indicate that good target recovery can be achieved with occupancy of the receive data matrix as low as 50%.Comment: 5 pages, ICASSP 201

    Dual-acting stapled peptides target both HIV-1 entry and assembly

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    Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD) of the HIV-1 capsid (CA) protein with an improved affinity (Kd ~ 1 μM) compared to CAI (Kd ~ 15 μM). NYAD-1 disrupts the formation of both immature- and mature-like virus particles in in vitro and cell-based assembly assays. In addition, it displays potent anti-HIV-1 activity in cell culture against a range of laboratory-adapted and primary HIV-1 isolates.<p></p> Results: In this report, we expanded the study to i,i + 7 hydrocarbon-stapled peptides to delineate their mechanism of action and antiviral activity. We identified three potent inhibitors, NYAD-36, -66 and -67, which showed strong binding to CA in NMR and isothermal titration calorimetry (ITC) studies and disrupted the formation of mature-like particles. They showed typical α-helical structures and penetrated cells; however, the cell penetration was not as efficient as observed with the i,i + 4 peptides. Unlike NYAD-1, the i,i + 7 peptides did not have any effect on virus release; however, they impaired Gag precursor processing. HIV-1 particles produced in the presence of these peptides displayed impaired infectivity. Consistent with an effect on virus entry, selection for viral resistance led to the emergence of two mutations in the gp120 subunit of the viral envelope (Env) glycoprotein, V120Q and A327P, located in the conserved region 1 (C1) and the base of the V3 loop, respectively.<p></p> Conclusion: The i,i + 7 stapled peptides derived from CAI unexpectedly target both CA and the V3 loop of gp120. This dual-targeted activity is dependent on their ability to penetrate cells as well as their net charge. This mechanistic revelation will be useful in further modifying these peptides as potent anti-HIV-1 agents.<p></p&gt

    Energy Content of Colliding Plane Waves using Approximate Noether Symmetries

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    This paper is devoted to study the energy content of colliding plane waves using approximate Noether symmetries. For this purpose, we use approximate Lie symmetry method of Lagrangian for differential equations. We formulate the first-order perturbed Lagrangian for colliding plane electromagnetic and gravitational waves. It is shown that in both cases, there does not existComment: 18 pages, accepted for publication in Brazilian J Physic

    Measurement of the CKM Matrix Element Vcb|V_{cb}| from B0D+νB^{0} \to D^{*-} \ell^+ \nu_\ell at Belle

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    We present a new measurement of the CKM matrix element Vcb|V_{cb}| from B0D+νB^{0} \to D^{*-} \ell^+ \nu_\ell decays, reconstructed with the full Belle data set of 711fb1711 \, \rm fb^{-1} integrated luminosity. Two form factor parameterizations, originally conceived by the Caprini-Lellouch-Neubert (CLN) and the Boyd, Grinstein and Lebed (BGL) groups, are used to extract the product F(1)ηEWVcb\mathcal{F}(1)\eta_{\rm EW}|V_{cb}| and the decay form factors, where F(1)\mathcal{F}(1) is the normalization factor and ηEW\eta_{\rm EW} is a small electroweak correction. In the CLN parameterization we find F(1)ηEWVcb=(35.06±0.15±0.56)×103\mathcal{F}(1)\eta_{\rm EW}|V_{cb}| = (35.06 \pm 0.15 \pm 0.56) \times 10^{-3}, ρ2=1.106±0.031±0.007\rho^{2}=1.106 \pm 0.031 \pm 0.007, R1(1)=1.229±0.028±0.009R_{1}(1)=1.229 \pm 0.028 \pm 0.009, R2(1)=0.852±0.021±0.006R_{2}(1)=0.852 \pm 0.021 \pm 0.006. For the BGL parameterization we obtain F(1)ηEWVcb=(34.93±0.23±0.59)×103\mathcal{F}(1)\eta_{\rm EW}|V_{cb}|= (34.93 \pm 0.23 \pm 0.59)\times 10^{-3}, which is consistent with the World Average when correcting for F(1)ηEW\mathcal{F}(1)\eta_{\rm EW}. The branching fraction of B0D+νB^{0} \to D^{*-} \ell^+ \nu_\ell is measured to be B(B0D+ν)=(4.90±0.02±0.16)%\mathcal{B}(B^{0}\rightarrow D^{*-}\ell^{+}\nu_{\ell}) = (4.90 \pm 0.02 \pm 0.16)\%. We also present a new test of lepton flavor universality violation in semileptonic BB decays, B(B0De+ν)B(B0Dμ+ν)=1.01±0.01±0.03 \frac{{\cal B }(B^0 \to D^{*-} e^+ \nu)}{{\cal B }(B^0 \to D^{*-} \mu^+ \nu)} = 1.01 \pm 0.01 \pm 0.03~. The errors correspond to the statistical and systematic uncertainties respectively. This is the most precise measurement of F(1)ηEWVcb\mathcal{F}(1)\eta_{\rm EW}|V_{cb}| and form factors to date and the first experimental study of the BGL form factor parameterization in an experimental measurement

    Angular analysis of B0K(892)0+B^0 \to K^\ast(892)^0 \ell^+ \ell^-

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    We present a measurement of angular observables, P4P_4', P5P_5', P6P_6', P8P_8', in the decay B0K(892)0+B^0 \to K^\ast(892)^0 \ell^+ \ell^-, where +\ell^+\ell^- is either e+ee^+e^- or μ+μ\mu^+\mu^-. The analysis is performed on a data sample corresponding to an integrated luminosity of 711 fb1711~\mathrm{fb}^{-1} containing 772×106772\times 10^{6} BBˉB\bar B pairs, collected at the Υ(4S)\Upsilon(4S) resonance with the Belle detector at the asymmetric-energy e+ee^+e^- collider KEKB. Four angular observables, P4,5,6,8P_{4,5,6,8}' are extracted in five bins of the invariant mass squared of the lepton system, q2q^2. We compare our results for P4,5,6,8P_{4,5,6,8}' with Standard Model predictions including the q2q^2 region in which the LHCb collaboration reported the so-called P5P_5' anomaly.Comment: Conference paper for LHC Ski 2016. SM prediction for P6P_{6}' corrected and reference for arXiv:1207.2753 adde

    Search for CPCP violation in the D+π+π0D^{+}\to\pi^{+}\pi^{0} decay at Belle

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    We search for CPCP violation in the charged charm meson decay D+π+π0D^{+}\to\pi^{+}\pi^{0}, based on a data sample corresponding to an integrated luminosity of 921 fb1\rm 921~fb^{-1} collected by the Belle experiment at the KEKB e+ee^{+}e^{-} asymmetric-energy collider. The measured CPCP violating asymmetry is [+2.31±1.24(stat)±0.23(syst)]%[+2.31\pm1.24({\rm stat})\pm0.23({\rm syst})]\%, which is consistent with the standard model prediction and has a significantly improved precision compared to previous results.Comment: 8 pages, 3 figure

    Measurement of Branching Fractions of Hadronic Decays of the Ωc0\Omega_c^0 Baryon

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    Using a data sample of 980 fb1{\rm fb}^{-1} of e+ee^+e^- annihilation data taken with the Belle detector operating at the KEKB asymmetric-energy e+ee^+e^- collider, we report the results of a study of the decays of the Ωc0\Omega_c^0 charmed baryon into hadronic final states. We report the most precise measurements to date of the relative branching fractions of the Ωc0\Omega_c^0 into Ωπ+π0\Omega^-\pi^+\pi^0, Ωπ+ππ+\Omega^-\pi^+\pi^-\pi^+, ΞKπ+π+\Xi^-K^-\pi^+\pi^+, and Ξ0Kπ+\Xi^0K^-\pi^+, as well as the first measurements of the branching fractions of the Ωc0\Omega_c^0 into ΞKˉ0π+\Xi^-\bar{K}^0\pi^+, Ξ0Kˉ0\Xi^0\bar{K}^0, and ΛKˉ0Kˉ0\Lambda \bar{K}^0\bar{K}^0, all with respect to the Ωπ+\Omega^-\pi^+ decay. In addition, we investigate the resonant substructure of these modes. Finally, we present a limit on the branching fraction for the decay Ωc0Σ+KKπ+\Omega_c^0\to\Sigma^+K^-K^-\pi^+
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