Vacancy complexes with oversized impurities in Si and Ge

In this paper we examine the electronic and geometrical structure of impurity-vacancy complexes in Si and Ge. Already Watkins suggested that in Si the pairing of Sn with the vacancy produces a complex with the Sn-atom at the bond center and the vacancy split into two half vacancies on the neighboring sites. Within the framework of density-functional theory we use two complementary ab initio methods, the pseudopotential plane wave (PPW) method and the all-electron Kohn-Korringa-Rostoker (KKR) method, to investigate the structure of vacancy complexes with 11 different sp-impurities. For the case of Sn in Si, we confirm the split configuration and obtain good agreement with EPR data of Watkins. In general we find that all impurities of the 5sp and 6sp series in Si and Ge prefer the split-vacancy configuration, with an energy gain of 0.5 to 1 eV compared to the substitutional complex. On the other hand, impurities of the 3sp and 4sp series form a (slightly distorted) substitutional complex. Al impurities show an exception from this rule, forming a split complex in Si and a strongly distorted substitutional complex in Ge. We find a strong correlation of these data with the size of the isolated impurities, being defined via the lattice relaxations of the nearest neighbors.Comment: 8 pages, 4 bw figure

Quasifree photoabsorption on neutron-proton pairs in 3He

Three-body photodisintegration of 3He is calculated in the photon energy range 200 - 400 MeV assuming quasifree absorption on np pairs both in initial quasideuteron and singlet configurations. The model includes the normal nucleonic current, explicit meson exchange currents and the Delta(1232)-isobar excitation. The total cross section is increased by a factor of about 1.5 compared with free deuteron photodisintegration. Well below and above the Delta region also some spin observables differ significantly from the ones of free deuteron disintegration due to the more compressed wave function of the correlated np pairs in 3He compared to the deuteron. The initial singlet state causes a significant change in the analyzing power Ay. These differences could presumably be seen at the conjugate angles where two-body effects are maximized and where photoreactions could complement similar pion absorption experiments. Figures by fax or post from [email protected]: 23 pages, report MKPH-T-94-10/HU-TFT-94-1

Hints of (trans-Planckian) asymptotic freedom in semiclassical cosmology

We employ the semiclassical approximation to the Wheeler-DeWitt equation in the spatially flat de Sitter Universe to investigate the dynamics of a minimally coupled scalar field near the Planck scale. We find that, contrary to naive intuition, the effects of quantum gravitational fluctuations become negligible and the scalar field states asymptotically approach plane-waves at very early times. These states can then be used as initial conditions for the quantum states of matter to show that each mode essentially originated in the minimum energy vacuum. Although the full quantum dynamics cannot be solved exactly for the case at hand, our results can be considered as supporting the general idea of asymptotic safety in quantum gravity.Comment: 11 pages, 2 figures; replaced to match content of published versio

A Large Solid Angle Study of Pion Absorption on He3

Measurements have been made of pi+ absorption on He3 at T_pi+ = 118, 162, and 239 MeV using the Large Acceptance Detector System (LADS). The nearly 4pi solid angle coverage of this detector minimizes uncertainties associated with extrapolations over unmeasured regions of phase space. The total absorption cross section is reported. In addition, the total cross section is divided into components in which only two or all three nucleons play a significant role in the process. These are the first direct measurements of the total and three nucleon absorption cross sections.Comment: 8 pages, LaTeX. 3 figures, anonymous ftp MITLNS.MIT.EDU, cd LADS. Submitted to PRL. PSI-PR-94-11 (Paul Scherrer Institute) and LNS 94-56 (MIT Lab. for Nucl. Sci.

Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles

Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and cardiovascular features of diabetes in man is not entirely clear. Here we evaluate at the molecular level the similarity between Zucker diabetic fatty (ZDF) rats, as a model of T2D-associated vascular complications, and human disease by urinary proteome analysis. Urine analysis of ZDF rats at early and late stages of disease compared to age- matched LEAN rats identified 180 peptides as potentially associated with diabetes complications. Overlaps with human chronic kidney disease (CKD) and cardiovascular disease (CVD) biomarkers were observed, corresponding to proteins marking kidney damage (eg albumin, alpha-1 antitrypsin) or related to disease development (collagen). Concordance in regulation of these peptides in rats versus humans was more pronounced in the CVD compared to the CKD panels. In addition, disease-associated predicted protease activities in ZDF rats showed higher similarities to the predicted activities in human CVD. Based on urinary peptidomic analysis, the ZDF rat model displays similarity to human CVD but might not be the most appropriate model to display human CKD on a molecular level

The pd <--> pi+ t reaction around the Delta resonance

The pd pi+ t process has been calculated in the energy region around the Delta-resonance with elementary production/absorption mechanisms involving one and two nucleons. The isobar degrees of freedom have been explicitly included in the two-nucleon mechanism via pi-- and rho-exchange diagrams. No free parameters have been employed in the analysis since all the parameters have been fixed in previous studies on the simpler pp pi+ d process. The treatment of the few-nucleon dynamics entailed a Faddeev-based calculation of the reaction, with continuum calculations for the initial p-d state and accurate solutions of the three-nucleon bound-state equation. The integral cross-section was found to be quite sensitive to the NN interaction employed while the angular dependence showed less sensitivity. Approximately a 4% effect was found for the one-body mechanism, for the three-nucleon dynamics in the p-d channel, and for the inclusion of a large, possibly converged, number of three-body partial states, indicating that these different aspects are of comparable importance in the calculation of the spin-averaged observables.Comment: 40 Pages, RevTex, plus 5 PostScript figure

Absence of an acute insulin response predicts onset of type 2 diabetes in a Caucasian population with impaired glucose tolerance

Context: In persons with impaired glucose tolerance (IGT), both impaired insulin secretion and insulin resistance contribute to the conversion to type 2 diabetes mellitus (T2DM). However, few studies have used criterion standard measures to asses the predictive value of impaired insulin secretion and insulin resistance for the conversion to T2DM in a Caucasian IGT population. Objectives: The objective of the study was to determine the predictive value of measures of insulin secretion and insulin resistance derived from a hyperglycemic clamp, including the disposition index, for the development of T2DM in a Caucasian IGT population. Design, Setting, and Participants: The population-based Hoorn IGT study consisted of 101 Dutch IGT subjects (aged < 75 yr), with mean 2-h plasma glucose values, of two separate oral glucose tolerance tests, between 8.6 and 11.1 mmol/liter. A hyperglycemic clamp at baseline was performed to assess first-phase and second-phase insulin secretion and insulin sensitivity. During follow-up, conversion to T2DM was assessed by means of 6-monthly fasting glucose levels and yearly oral glucose tolerance tests. Results: The cumulative incidence of T2DM was 34.7%. Hazard ratio for T2DM development adjusted for age, sex, and body mass index was 5.74 [95% confidence interval (CI) 2.60-12.67] for absence of first insulin peak, 1.58 (95% CI 0.60-4.17) for lowest vs. highest tertile of insulin sensitivity, and 1.78 (95% CI 0.65-4.88) for lowest vs. highest tertile of the disposition index. Conclusions: In these Caucasian persons with IGT, the absence of the first insulin peak was the strongest predictor of T2DM. Copyright © 2008 by The Endocrine Society