Stable circulation modes in a dual-core matter-wave soliton laser

We consider a model of a matter-wave laser generating a periodic array of solitary-wave pulses. The system, a general version of which was recently proposed in Ref. [5], is composed of two parallel tunnel-coupled cigar-shaped traps (a reservoir and a lasing cavity), solitons being released through a valve at one edge of the cavity. We report a stable lasing mode accounted for by circulations of a narrow soliton in the cavity, which generates an array of strong pulses (with 1,000 - 10,000 atoms in each, the array's duty cycle ~ 30%) when the soliton periodically hits the valve.Comment: J. of Physics B: At. Mol. Opt. Physics, in pres

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.

Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC). Studies describing the mechanisms by which metformin affects HGSC are ongoing, but detailed analysis of its effect on the cellular metabolism of both HGSC cells and their precursor, normal fallopian tube secretory epithelial cells (FTSECs), is lacking. We addressed the effects of metformin and the more potent biguanide, phenformin, on HGSC cell lines and normal immortalized FTSECs. Cell proliferation assays identified that FTSECs and a subset of HGSC cell lines are relatively resistant to the anti-proliferative effects of metformin. Bioenergetic and metabolomic analyses were used to metabolically differentiate the metformin-sensitive and metformin-resistant cell lines. Bioenergetically, biguanides elicited a significant decrease in mitochondrial respiration in all HGSC cells and FTSECs. However, biguanides had a greater effect on mitochondrial respiration in metformin sensitive cells. Metabolomic analysis revealed that metformin and phenformin generally induce similar changes in metabolic profiles. Biguanide treatment led to a significant increase in NADH in FTSECs and HGSC cells. Interestingly, biguanide treatment induced changes in the levels of mitochondrial shuttle metabolites, glycerol-3-phopshate (G3P) and aspartate, specifically in HGSC cell lines and not in FTSECs. Greater alterations in G3P or aspartate levels were also found in metformin sensitive cells relative to metformin resistant cells. These data identify bioenergetic and HGSC-specific metabolic effects that correlate with metformin sensitivity and novel metabolic avenues for possible therapeutic intervention

Behavior of X-Ray Dust Scattering and Implications for X-Ray Afterglows of Gamma-Ray Bursts

The afterglows of gamma-ray bursts (GRBs) have commonly been assumed to be due to shocks sweeping up the circum-stellar medium. However, most GRBs have been found in dense star-forming regions where a significant fraction of the prompt X-ray emission can be scattered by dust grains. Here we revisit the behavior of dust scattering of X-rays in GRBs. We find that the features of some X-ray afterglows from minutes to days after the gamma-ray triggers are consistent with the scattering of prompt X-ray emission from GRBs off host dust grains. This implies that some of the observed X-ray afterglows (especially those without sharp rising and decaying flares) could be understood with a dust-scattering--driven emission model.Comment: ApJ, in pres

1+1 Dimensional Compactifications of String Theory

We argue that stable, maximally symmetric compactifications of string theory to 1+1 dimensions are in conflict with holography. In particular, the finite horizon entropies of the Rindler wedge in 1+1 dimensional Minkowski and anti de Sitter space, and of the de Sitter horizon in any dimension, are inconsistent with the symmetries of these spaces. The argument parallels one made recently by the same authors, in which we demonstrated the incompatibility of the finiteness of the entropy and the symmetries of de Sitter space in any dimension. If the horizon entropy is either infinite or zero the conflict is resolved.Comment: 11 pages, 2 figures v2: added discussion of AdS_2 and comment

Interface states and anomalous quantum oscillations in graphene hybrid structures

One- and two-layer graphene have recently been shown to feature new physical phenomena such as unconventional quantum Hall effects and prospects of supporting a non-silicon technological platform using epitaxial graphene. While both one- and two-layer graphene have been studied extensively, continuous sheets of graphene possessing both parts have not yet been explored. Here we report a study of such graphene hybrid structures. In a bulk hybrid featuring two large-area one- and two-layer graphene and an interface between them, two sets of Landau levels and features related to the interface were found. In edge hybrids featuring a large two-layer graphene with narrow one-layer graphene edges, we observed an anomalous suppression in quantum oscillation amplitude due to the locking of one- and two-layer graphene Fermi energies and emergent chiral interface states. These findings demonstrate the importance of these hybrid structures whose unique interface states and related phenomena deserve further studies.Comment: 4 pages, 4 figure

A model of a dual-core matter-wave soliton laser

We propose a system which can generate a periodic array of solitary-wave pulses from a finite reservoir of coherent Bose-Einstein condensate (BEC). The system is built as a set of two parallel quasi-one-dimensional traps (the reservoir proper and a pulse-generating cavity), which are linearly coupled by the tunneling of atoms. The scattering length is tuned to be negative and small in the absolute value in the cavity, and still smaller but positive in the reservoir. Additionally, a parabolic potential profile is created around the center of the cavity. Both edges of the reservoir and one edge of the cavity are impenetrable. Solitons are released through the other cavity's edge, which is semi-transparent. Two different regimes of the intrinsic operation of the laser are identified: circulations of a narrow wave-function pulse in the cavity, and oscillations of a broad standing pulse. The latter regime is stable, readily providing for the generation of an array containing up to 10,000 permanent-shape pulses. The circulation regime provides for no more than 40 cycles, and then it transforms into the oscillation mode. The dependence of the dynamical regime on parameters of the system is investigated in detail.Comment: Journal of Physics B, in pres

Probing SO(10) symmetry breaking patterns through sfermion mass relations

We consider supersymmetric SO(10) grand unification where the unified gauge group can break to the Standard Model gauge group through different chains. The breaking of SO(10) necessarily involves the reduction of the rank, and consequent generation of non-universal supersymmetry breaking scalar mass terms. We derive squark and slepton mass relations, taking into account these non-universal contributions to the sfermion masses, which can help distinguish between the different chains through which the SO(10) gauge group breaks to the Standard Model gauge group. We then study some implications of these non-universal supersymmetry breaking scalar masses for the low energy phenomenology.Comment: 13 pages, latex using revtex4, contains 2 figures, replaced with version accepted for publicatio

Liquid oil painting: Free and forced convection in an enclosure with mechanical and thermal forcing

A fluid dynamics video is linked to this article, which have been submitted to the Gallery of Fluid Motion as part of the 65th American Physical Society meeting of the Division of Fluid Dynamics, held in San Diego, California, USA, over 17-20 November 2012. The video serves to visualize flows generated in a rectangular enclosure that are subjected to both mechanical and thermal forcing through a common horizontal boundary. This system exhibits features consistent with either horizontal convection or lid-driven cavity flows depending on the ratio between thermal and mechanical stirring, and three different cases are visualized in the linked videos.Comment: 2 video files attached, 4 pages, 1 figure. This article is submitted accompanying a video submitted to the Gallery of Fluid Motion as part of the 65th Division of Fluid Dynamics meeting of the American Physical Society (17-20 November, San Diego, CA, USA

Synthesis and Properties of Dipyridylcyclopentenes

A short and general route to the substituted dipyridylcyclopentenes was explored and several new compounds belonging to this new group of diarylethenes were synthesized. The study of their photochromic and thermochromic properties shows that the rate of the thermal ring opening is strongly dependent on the polarity of the solvent.