Pemanfaatan Teknologi Pengolahan Limbah Bagi Peternak Puyuh Ramah Lingkungan Kota Kendari Sulawesi Tenggara

Tujuan pelaksanaan kegiatan Program Kemitraan Masyarakat Internal UHO ini adalah untuk meningkatkan pemahaman dan pengetahuan peternak puyuh di Kelurahan Rahandouna dan Watubangga, Kota Kendari mengenai teknologi pengolahan limbah ternak puyuh. Metode yang digunakan adalah penyuluhan dan demonstrasi langsung (praktek di lapangan). Tahapan kegiatan yang dilakukan adalah sosialisasi program, penyuluhan tentang manajemen pemeliharaan puyuh yang baik, potensi dan efek limbah peternakan puyuh, pelatihan teknik pengolahan kotoran puyuh menjadi biogas, dan rehabilitasi kandang puyuh. Berdasarkan kondisi yang dijumpai di lapangan, diketahui bahwa teknologi pengolahan limbah peternakan puyuh menjadi biogas sangat dibutuhkan peternak. Teknologi ini menjadi solusi atas polusi bau yang ditimbulkan peternakan puyuh di kawasan padat penduduk Kota Kendari. Proses monitoring dan pendampingan peternak dilakukan secara berkala guna menjamin keberlangsungan pelaksanaan program

The Development of Palliative Community Health Nursing to Increase Family\u27s Autonomy in Caring Patient with Cancer at Home

Introduction: Cancer still remains a disease with high mortality rate. Sustainable health services for cancer survivors are important to prevent relapse and improve patient\u27s quality of life. PCHN (Palliative Community Health Nursing) is a packet of community health nursing services given to the family and cancer\u27s patient at home, focused on promotive and preventive activities. The aim of this study was to analyze the influence of palliative community health nursing to increase family\u27s autonomy in caring patient with cancer at home. Method: This study was used pre-experiment design. The populations were family who lived with cancer\u27s patient post treatment. Samples were taken by purposive sampling technique; consist of 7 people. Variable independent was PCHN. Variable dependent were family\u27s autonomy in caring patient with cancer at home collected by using observation form. The data were then analyzed by using Wilcoxon Signed Rank Test, with α ≤ 0.05. Results: The results had showed the differences between family\u27s autonomy in caring patient at home before and after PCHN (p = 0.025). Discussion: PCHN can increase family\u27s autonomy in caring cancer\u27s patient at home. The implementation of PCHN through home visit can give informational support about cancer and treatment at home to the families. PCHN can be used as one of method to improve palliative services at community, in order to increase cancer\u27s patient quality of life. Further research, should develop PCHN which involve multidicipline team, such as health care provider, clergy, and health volunteer

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa.

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare monogenic blistering disorder caused by the lack of functional type VII collagen, leading to skin fragility and subsequent trauma-induced separation of the epidermis from the underlying dermis. A total of 46% of patients with RDEB harbor at least one premature termination codon (PTC) mutation in COL7A1, and previous studies have shown that aminoglycosides are able to overcome RDEB PTC mutations by inducing read-through and incorporation of an amino acid at the PTC site. However, aminoglycoside toxicity will likely prevent widespread clinical application. Here the FDA-approved drug amlexanox was tested for its ability to read-through PTC mutations in cells derived from patients with RDEB. Eight of 12 different PTC alleles responded to treatment and produced full length protein, in some cases more than 50% relative to normal controls. Read-through type VII collagen was readily detectable in cell culture media and also localized to the dermal-epidermal junction in organotypic skin culture. Amlexanox increased COL7A1 transcript and the phosphorylation of UPF-1, an RNA helicase associated with nonsense-mediated mRNA decay, suggesting that amlexanox inhibits nonsense-mediated mRNA decay in cells from patients with RDEB that respond to read-through treatment. This preclinical study demonstrates the potential of repurposing amlexanox for the treatment of patients with RDEB harboring PTC mutation in COL7A1

Refraction Wiggles for Measuring Fluid Depth and Velocity from Video

We present principled algorithms for measuring the velocity and 3D location of refractive fluids, such as hot air or gas, from natural videos with textured backgrounds. Our main observation is that intensity variations related to movements of refractive fluid elements, as observed by one or more video cameras, are consistent over small space-time volumes. We call these intensity variations “refraction wiggles”, and use them as features for tracking and stereo fusion to recover the fluid motion and depth from video sequences. We give algorithms for 1) measuring the (2D, projected) motion of refractive fluids in monocular videos, and 2) recovering the 3D position of points on the fluid from stereo cameras. Unlike pixel intensities, wiggles can be extremely subtle and cannot be known with the same level of confidence for all pixels, depending on factors such as background texture and physical properties of the fluid. We thus carefully model uncertainty in our algorithms for robust estimation of fluid motion and depth. We show results on controlled sequences, synthetic simulations, and natural videos. Different from previous approaches for measuring refractive flow, our methods operate directly on videos captured with ordinary cameras, do not require auxiliary sensors, light sources or designed backgrounds, and can correctly detect the motion and location of refractive fluids even when they are invisible to the naked eye.Shell ResearchMotion Sensing Wi-Fi Sensor Networks Co. (Grant 6925133)National Science Foundation (U.S.). Graduate Research Fellowship (Grant 1122374)Microsoft Research (PhD Fellowship

Age group, location or pedagogue: factors affecting parental choice of kindergartens in Hungary

Hungary has experienced significant political, economic, demographic and social changes since the end of Soviet domination in the 1990s. The gradual move towards liberal-democracy has been accompanied by growing emphasis on individualism, choice and diversity. Universal kindergarten provision for 5-6 year olds is a long established feature of the Hungarian education system, but little is known about parental choice (Török, 2004). A case study (Yin, 2004) of factors influencing parental choice and satisfaction was undertaken in one Hungarian town. This was based on a survey of 251 parents of children attending both mixed-age and same-age groups across 12 kindergartens. Parents suggested that the most important influences were geographical location and the individual pedagogue(s). Given that traditionally each pedagogue follows ‘their’ cohort from kindergarten entry to primary school, their influence appears heightened. Although generally satisfied with their chosen arrangement, parents from same-age groups expressed significantly more confidence and satisfaction, particularly in relation to cognitive development and preparation for school. Parents appear less convinced about the trend towards mixed-age groups and questions are raised about sufficiency of evidence of their benefits in a Hungarian context and the driving factors behind change

Noncommutative Inspired Black Holes in Extra Dimensions

In a recent string theory motivated paper, Nicolini, Smailagic and Spallucci (NSS) presented an interesting model for a noncommutative inspired, Schwarzschild-like black hole solution in 4-dimensions. The essential effect of having noncommutative co-ordinates in this approach is to smear out matter distributions on a scale associated with the turn-on of noncommutativity which was taken to be near the 4-d Planck mass. In particular, NSS took this smearing to be essentially Gaussian. This energy scale is sufficiently large that in 4-d such effects may remain invisible indefinitely. Extra dimensional models which attempt to address the gauge hierarchy problem, however, allow for the possibility that the effective fundamental scale may not be far from $\sim$ 1 TeV, an energy regime that will soon be probed by experiments at both the LHC and ILC. In this paper we generalize the NSS model to the case where flat, toroidally compactified extra dimensions are accessible at the Terascale and examine the resulting modifications in black hole properties due to the existence of noncommutativity. We show that while many of the noncommutativity-induced black hole features found in 4-d by NSS persist, in some cases there can be significant modifications due the presence of extra dimensions. We also demonstrate that the essential features of this approach are not particularly sensitive to the Gaussian nature of the smearing employed by NSS.Comment: 30 pages, 12 figures; slight text modifications and references adde

Charged Particles in a 2+1 Curved Background

The coupling to a 2+1 background geometry of a quantized charged test particle in a strong magnetic field is analyzed. Canonical operators adapting to the fast and slow freedoms produce a natural expansion in the inverse square root of the magnetic field strength. The fast freedom is solved to the second order. At any given time, space is parameterized by a couple of conjugate operators and effectively behaves as the `phase space' of the slow freedom. The slow Hamiltonian depends on the magnetic field norm, its covariant derivatives, the scalar curvature and presents a peculiar coupling with the spin-connection.Comment: 22 page

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

Epidermolysa bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene

BACKGROUND Heritable forms of epidermolysis bullosa (EB) constitute a heterogeneous group of skin disorders of genetic aetiology that are characterised by skin and mucous membrane blistering and ulceration in response to even minor trauma. Here we report the occurrence of EB in three Danish Hereford cattle from one herd. RESULTS Two of the animals were necropsied and showed oral mucosal blistering, skin ulcerations and partly loss of horn on the claws. Lesions were histologically characterized by subepidermal blisters and ulcers. Analysis of the family tree indicated that inbreeding and the transmission of a single recessive mutation from a common ancestor could be causative. We performed whole genome sequencing of one affected calf and searched all coding DNA variants. Thereby, we detected a homozygous 2.4 kb deletion encompassing the first exon of the LAMC2 gene, encoding for laminin gamma 2 protein. This loss of function mutation completely removes the start codon of this gene and is therefore predicted to be completely disruptive. The deletion co-segregates with the EB phenotype in the family and absent in normal cattle of various breeds. Verifying the homozygous private variants present in candidate genes allowed us to quickly identify the causative mutation and contribute to the final diagnosis of junctional EB in Hereford cattle. CONCLUSIONS Our investigation confirms the known role of laminin gamma 2 in EB aetiology and shows the importance of whole genome sequencing in the analysis of rare diseases in livestock