Synthesis and exchange reactions of some polymeric benzotriazolides

The benzotriazolides of N-methacryloylglycine, N-methacrylolyl-ε-aminocaproic acid, and 4-methacryloxybenzoic acid, have been prepared and polymerized. The exchange reactions of the resulting polymers with amines, alcohols, and phenol have been studied

Synthesis and exchange reactions of biodegradable drug-binding matrices

Succinic esters of starch and dextrane (STS and DTS) have been prepared and transformed into the corresponding imidazolides. These are difficult to isolate in a pure state. Without previous isolation, however, they react smoothly with alcohols or amines giving the corresponding polymeric esters or amides. STS benzotriazolide has also been prepared, and isolated in a pure state. It has been found to have the same reactivity towards alcohols and amines than other previously described polymeric benzotriazolides. These results demonstrate that STS or DTS activated amides offer new opportunities to prepare polymer drug adducts with a main backbone degradable to safe metabolites in the body fluid

Activated derivatives of succinic and glutaric half-esters of polypropylene glycols, and their exchange reactions with hydroxy- and amino- compounds

Succinic and glutaric halfesters of polypropyleneglycols have been prepared, and transformed into the corresponding imidazolides and benzotriazolides. The exchange reactions of the latter with hydroxylated and aminated compounds have been studie

Synthesis of tertiary poly(amido-amine)s with amido- and amino groups randomly arranged along the macromolecular chain

A new synthesis of poly(amido-amine)s from bis (secondary amine)s and acryloyl chloride has been studied, leading to polymers in which the amido- and amino-groups are randomly arranged along the macromolecular chain. A poly(amido-amine) based on piperazine, chosen as the mother compound, has been fully characterized by 13C n.m.r. as well as by identification and quantitative evaluation of its hydrolysis product

Syntheses and thermodynamic studies on the protonation behaviour of polymers containing acylpiperazinyl units in the backbone or in the side chain of a vinyl polymer

Linear poly(1,4-piperazinediyl-1-oxotrimethylene) (1), in which amido and tertiary amino groups regularly alternate along the macromolecular chain, the isomeric poly[1-(1-piperazinyl-carbonyl)ethylene] (8) for polyvinylic structure and its N-methylated derivative, poly{1-[(4-methyl-1-piperazinyl)carbonyl]ethylene} (3), were prepared and characterized. Their protonation behaviour was investigated in aqueous solution by potentiometric and calorimetric techniques. In all cases the basicity constants were found to decrease linearly with α (the degree of protonation), whereas the enthalpy changes show a different behaviour toward protonation. The thermodynamic values indicate the important role of hydrophobic interaction

Synthesis and characterization of piperazine-derived poly(amido-amine)s with different distribution of amido- and amino-groups along the macromolecular chain

Four poly(amido-amine)s based on piperazine have been synthesized by poly(acylation-addition) reaction of piperazind with various activated derivatives of acrylic acid. In these polymers, amido-, and amino groups are randomly arranged along the macromolecular chain. These polymers have been fully characterized by hydrolytic analysis, 13C n.m.r., and potentiometric techniques