Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism

No abstract available

Laser communication system is insensitive to atmospherically induced noise

Angle modulated transmitted reference heterodyne laser communication system is insensitive to atmospherically induced amplitude noise fluctuations and phase distortions

Linearized analysis versus optimization-based nonlinear analysis for nonlinear systems

For autonomous nonlinear systems stability and input-output properties in small enough (infinitesimally small) neighborhoods of (linearly) asymptotically stable equilibrium points can be inferred from the properties of the linearized dynamics. On the other hand, generalizations of the S-procedure and sum-of-squares programming promise a framework potentially capable of generating certificates valid over quantifiable, finite size neighborhoods of the equilibrium points. However, this procedure involves multiple relaxations (unidirectional implications). Therefore, it is not obvious if the sum-of-squares programming based nonlinear analysis can return a feasible answer whenever linearization based analysis does. Here, we prove that, for a restricted but practically useful class of systems, conditions in sum-of-squares programming based region-of-attraction, reachability, and input-output gain analyses are feasible whenever linearization based analysis is conclusive. Besides the theoretical interest, such results may lead to computationally less demanding, potentially more conservative nonlinear (compared to direct use of sum-of-squares formulations) analysis tools

Revealed preference and self-insurance - Can we learn from the self-employed in Chile?

Financial sector development is a critical area of effective social protection policy. A well-regulated financial sector can complement government efforts to keep households from falling into poverty - by supplying the instruments needed to pool risks, or to self-insure against losses because of the death, or disability of a household member, unexpected loss of employment, or inability to work in old age. But many of the policy recommendations that can be drawn from the social risk management framework, rest on the strong assumption that risk, and time preferences are uniform across individuals, or households. Policies meant to encourage participation in public pension systems, and to reduce evasion where such systems are mandatory (by more closely aligning benefits with payroll contributions, or introducing individual retirement accounts) implicitly attempt to emulate the savings behavior of individuals, and households faced with fully functioning capital markets, and perfect information. If no allowance is made for variation in preferences, however, the welfare effects of policy reforms will vary across the target population. Mandated social security, even if actuarially fair for most, is likely to impose welfare losses on those less inclined to save, and insure. That said, a clearer picture of individual and household preferences, and how they vary across the population, can help governments design social security systems that complement private savings, and insurance instruments. The authors present the results of a field experiment, designed to produce an empirical measure of risk aversion, and time preferences of selected groups in Chile, which in 1981 pioneered social security reform with a transition to individual retirement accounts. The experiment was designed primarily to establish whether the time, and risk preferences of the self-employed differ significantly from those of wage, and salaried workers. They find no significant differences in mean risk, and time preferences between the self-employed, and employees, or between the contributing, and non-contributing employees. But they find significant differences in these preferences between the contributing, and non-contributing self-employed. Among the self-employed, those who are more patient choose to contribute to the pension system. However, the contributing self-employed are significantly more tolerant of risk than the non-contributing self-employed, a finding that conflicts with the assumption that the formal pension system is the only source of insurance against poverty in old age. The Chilean pension system may be viewed with some trepidation by its pool of potential clients. Since risk aversion declines with education, the participation of the economically active who are free to choose, could be enhanced by a campaign carefully designed to raise awareness, allay fears, and inform people of the benefits of saving for retirement in the formal pension system.Health Economics&Finance,Payment Systems&Infrastructure,Labor Policies,Environmental Economics&Policies,Banks&Banking Reform,Environmental Economics&Policies,Health Economics&Finance,Insurance&Risk Mitigation,Banks&Banking Reform,Health Monitoring&Evaluation

Teacher Contract Non-Renewal in the Rocky Mountains

Success for students in the 21st century increasingly relies on competencies and proficiencies typically available on]y through formal educational processes. Researchers have noted the paramount importance of quality teaching as the important criterion for student success (Haycock, 1998; Marzano, 2003). Recent reforms have increased the expectation that school principals energetically address teacher evaluations and subsequently remove ineffective teachers. These recent reforms tend to have common priorities, including emphasizing high quality teaching, evaluating teachers for merit pay purposes, and linking evaluation to student performance with an emphasis on the removal of ineffective teachers from the classroom

The Galeleo spacecraft magnetometer boom

The Galileo spacecraft utilizes a deployable lattice boom to position three science instruments at remote distances from the spacecraft body. An improved structure and mechanism to precisely control deployment of the boom, and the unique deployment of an outer protective cover are described

Comics und der myopische Blick : Strafen für unerwartete und wirkungsvolle Texte

A remarkable indictment and conviction following the sale of an ‘obscene’ comic book invites us to examine arguments brought forth to describe a specifically childlike reception of new media, as usually suggested by those who would motivate legal restrictions for such media. Trying to explain some perceived contradictions on the surface of these arguments, we discuss whether it is the failure or rather the extreme success of texts that is marked as ‘dangerous’ in such contexts

Are health care payments in Albania catastrophic? Evidence form ALSMS 2002, 2005 and 2008

The absent or poorly functioning risk pooling mechanisms and high amounts of out-of-pocket payments for health care expose households to financial risks associated with major illnesses or accidents. The aim of this paper is to analyse the extent to which out-of-pocket health spending impoverish the households in Albania. The study augments the existing evidence by analysing the dynamics of such payments over different years and the weight that informal payments have in the total out-of-pocket health spending. The data used in this study come from Albania Living Standard Measurement Survey (ALSMS) for 2002, 2005 and 2008. We measure headcount catastrophic payments using different thresholds and the decomposition of indicators by expenditure quintiles to understand better their effects. We find that out-of-pocket and informal payments have increased in real value throughout the years. Even though their catastrophic effect has gone down (due also to declining trends in absolute poverty), the effect for the poorest expenditure quintiles remains high. Out-of-pocket payments deepen the poverty headcount and also enlarge the poverty gap and again the effect is larger for the poorest quintiles. Future policy interventions should provide better protection mechanisms for the poor by providing exemption criteria or subsidised transport and should seek to address the widespread informal payments in the country.informal payments, out-of-pocket payments, health care expenditure, impoverishment, Albania LSMS, Albania, living standard, poverty

Seeking solutions to Vulnerability in Old Age: Preferences, constraints, and alternatives for coverage under Peru's pension system

Exploiting new data from a survey and behavioral experiment conducted in Peru we analyze individuals?preferences for securing income in old age. We identify a group that is unrationed by the mandate to save in Peruç—´ pension system, and draw insights from their affiliation and contribution behavior. Among the unrationed, those who are more tolerant of risk, have more children, and have a greater share of housing in their accumulated assets are less likely to affiliate and/or contribute to the formal pensions system. Further, the less risk tolerant choose private individual retirement accounts over a publicly administered pension system.Pensions, vulnerability, risk preferences, Latin America