Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands

Investigation of X-ray cavities in the cooling flow system Abell 1991

We present results based on the systematic analysis of \textit{Chandra} archive data on the X-ray bright Abell Richness class-I type cluster Abell 1991 with an objective to investigate properties of the X-ray cavities hosted by this system. The unsharp masked image as well as 2-d $\beta$ model subtracted residual image of Abell 1991 reveals a pair of X-ray cavities and a region of excess emission in the central $\sim$12 kpc region. Both the cavities are of ellipsoidal shape and exhibit an order of magnitude deficiency in the X-ray surface brightness compared to that in the undisturbed regions. Spectral analysis of X-ray photons extracted from the cavities lead to the temperature values equal to $1.77_{-0.12}^{+0.19}$ keV for N-cavity and $1.53_{-0.06}^{+0.05}$ keV for S-cavity, while that for the excess X-ray emission region is found to be equal to $2.06_{-0.07}^{+0.12}$ keV. Radial temperature profile derived for Abell 1991 reveals a positive temperature gradient, reaching to a maximum of 2.63 keV at $\sim$ 76 kpc and then declines in outward direction. 0.5$-$2.0 keV soft band image of the central 15\arcsec region of Abell 1991 reveals relatively cooler three different knot like features that are about 10\arcsec off the X-ray peak of the cluster. Total power of the cavities is found to be equal to $\sim 8.64\times 10^{43}$ \lum, while the X-ray luminosity within the cooling radius is found to be 6.04 $\times 10^{43}$ \lum, comparison of which imply that the mechanical energy released by the central AGN outburst is sufficient to balance the radiative loss.Comment: 29 pages, 12 figures and 3 tables, accepted for publication in Astrophysics and Space Scienc

Direct to consumer advertising via the Internet, a study of hip resurfacing

With increased use of the internet for health information and direct to consumer advertising from medical companies, there is a concern about the quality of the information available for patients. The aim of this study was to examine the quality of health information on the internet for hip resurfacing. An assessment tool was designed to measure quality of information. Websites were measured on credibility of source; usability; currentness of the information; content relevance; content accuracy/completeness and disclosure/bias. Each website assessed was given a total score, based on number of scores achieved from the above categories websites were further analysed on author, geographical origin and possession of an independent credibility check. There was positive correlation between the overall score for the website and the score of each website in each assessment category. Websites by implant companies, doctors and hospitals scored poorly. Websites with an independent credibility check such as Health on the Net (HoN) scored twice the total scores of websites without. Like other internet health websites, the quality of information on hip resurfacing websites is variable. This study highlights methods by which to assess the quality of health information on the internet and advocates that patients should look for a statement of an "independent credibility check" when searching for information on hip resurfacing

Analysis of interconnection between Concurrent Engineering and Human Resource Management

In today\u27s global economy; the competition in market among various organizations has been increased by great extent. The success in market is depending upon innovative research in product design and development as well as its quick launching in market. Thus the main aim of the concept of Concurrent Engineering is to speed up the every process that occurs during production and reducing the new product launching time in the market. But at the same time the impact of human resource management on all the activities from hiring new employees to achieving the organizational goal can\u27t be neglected. The above mentioned activity of concurrent engineering is only possible if there is proper co-ordination and co-operation among various organizational departments and effective communication in employees. Also proper training to the employees for improving not only technical skills but also interpersonal skills of employees will lead towards successful achievement of an organizational goal. Hence Human Resource Management undividable interconnection with Concurrent Engineering if properly understood and studied. Thus, implementation of both concepts give rise to long term benefits to organization in terms of customer satisfaction and improved interest of shareholders as well as stakeholders. Using proper methodology it is easy to implement Human Resource Management based Concurrent Engineering to be a market leader in today\u27s cut- throat competition in this world

Participatory cotton breeding for organic and low input farming in Central India

Up to 80% of world’s organic cotton is produced in India. However, involved producers are facing increased difficulties to find suitable cultivars. Few hybrids selected for high input farming and genetically-modified (GM) cotton, which is explicitly excluded in organic farming, are presently dominating the Indian seed market. In addition farmers have lost their traditional knowledge on seed production and hybrid seed needs to be purchased each season

Statistical Assertions for Validating Patterns and Finding Bugs in Quantum Programs

In support of the growing interest in quantum computing experimentation, programmers need new tools to write quantum algorithms as program code. Compared to debugging classical programs, debugging quantum programs is difficult because programmers have limited ability to probe the internal states of quantum programs; those states are difficult to interpret even when observations exist; and programmers do not yet have guidelines for what to check for when building quantum programs. In this work, we present quantum program assertions based on statistical tests on classical observations. These allow programmers to decide if a quantum program state matches its expected value in one of classical, superposition, or entangled types of states. We extend an existing quantum programming language with the ability to specify quantum assertions, which our tool then checks in a quantum program simulator. We use these assertions to debug three benchmark quantum programs in factoring, search, and chemistry. We share what types of bugs are possible, and lay out a strategy for using quantum programming patterns to place assertions and prevent bugs.Comment: In The 46th Annual International Symposium on Computer Architecture (ISCA '19). arXiv admin note: text overlap with arXiv:1811.0544

Pauli spin blockade in CMOS double quantum dot devices

Silicon quantum dots are attractive candidates for the development of scalable, spin-based qubits. Pauli spin blockade in double quantum dots provides an efficient, temperature independent mechanism for qubit readout. Here we report on transport experiments in double gate nanowire transistors issued from a CMOS process on 300 mm silicon-on-insulator wafers. At low temperature the devices behave as two few-electron quantum dots in series. We observe signatures of Pauli spin blockade with a singlet-triplet splitting ranging from 0.3 to 1.3 meV. Magneto-transport measurements show that transitions which conserve spin are shown to be magnetic-field independent up to B = 6 T.Comment: 5 pages , 4 figure

The Schrodinger equation with Hulthen potential plus ring-shaped potential

We present the solutions of the Schr$\ddot{o}$dinger equation with the Hulth$\acute{e}$n potential plus ring-shape potential for $\ell\neq 0$ states within the framework of an exponential approximation of the centrifugal potential.Solutions to the corresponding angular and radial equations are obtained in terms of special functions using the conventional Nikiforov-Uvarov method. The normalization constant for the Hulth$\acute{e}$n potential is also computed.Comment: Typed with LateX,12 Pages, Typos correcte

Character association and path analysis studies in brinjal (Solanum melongena L.) genotypes

Character association and path analysis in sixty genotypes of brinjal was studied for 17 important characters. The character association studies revealed that the total yield per plant had significant and positive association with plant height (0.385), plant spread (0.660), number of primary branches (0.545), stem girth (0.539) at 90 days after transplanting (DAT), early yield per plant, number of fruits per plant and fruit diameter. While it was negatively and significantly associated with days to first flowering (-0.302 and -0.230), days to 50 per cent flowering (-0.272 and 0.229) and days to first fruit maturity (-0.164 and -0.168) at both genotypic and phenotypic level. Narrow differences between the genotypic and phenotypic correlation coefficients were observed for various traits in the present findings. This indicates the lesser influence of the environment in the expression of these traits and presence of strong inherent association among the traits. Path analysis studies revealed that significant positive association at genotypic level among the traits viz., plant height (0.235), leaf area (at 90 DAT) (0.228), days to first fruit maturity (0.162), number of fruits per cluster (0.280) and early yield per plant (1.903) had exhibited true association with direct effect on yield per plant. The direct selection for these traits would be rewarding for improvement in the total yield per plant

Bandwidth selection for kernel density estimation with length-biased data

Length-biased data are a particular case of weighted data, which arise in many situations: biomedicine, quality control or epidemiology among others. In this paper we study the theoretical properties of kernel density estimation in the context of length-biased data, proposing two consistent bootstrap methods that we use for bandwidth selection. Apart from the bootstrap bandwidth selectors we suggest a rule-of-thumb. These bandwidth selection proposals are compared with a least-squares cross-validation method. A simulation study is accomplished to understand the behaviour of the procedures in finite samples