Observation of a J^PC = 1-+ exotic resonance in diffractive dissociation of 190 GeV/c pi- into pi- pi- pi+

The COMPASS experiment at the CERN SPS has studied the diffractive dissociation of negative pions into the pi- pi- pi+ final state using a 190 GeV/c pion beam hitting a lead target. A partial wave analysis has been performed on a sample of 420000 events taken at values of the squared 4-momentum transfer t' between 0.1 and 1 GeV^2/c^2. The well-known resonances a1(1260), a2(1320), and pi2(1670) are clearly observed. In addition, the data show a significant natural parity exchange production of a resonance with spin-exotic quantum numbers J^PC = 1-+ at 1.66 GeV/c^2 decaying to rho pi. The resonant nature of this wave is evident from the mass-dependent phase differences to the J^PC = 2-+ and 1++ waves. From a mass-dependent fit a resonance mass of 1660 +- 10+0-64 MeV/c^2 and a width of 269+-21+42-64 MeV/c^2 is deduced.Comment: 7 page, 3 figures; version 2 gives some more details, data unchanged; version 3 updated authors, text shortened, data unchange

Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

EYE EAR NOSE & THROAT HOSP,NEW ORLEANS,LA 70112ESCOLA PAULISTA MED SCH,BR-04023 São Paulo,BRAZILESCOLA PAULISTA MED SCH,BR-04023 São Paulo,BRAZILWeb of Scienc

miRNA-21 ablation protects against liver injury and necroptosis in cholestasis

Inhibition of microRNA-21 (miR-21) prevents necroptosis in the mouse pancreas. Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation (BDL) murine model. We aimed to evaluate the role of miR-21 in mediating deleterious processes associated with cholestasis. Mechanistic studies established a functional link between miR-21 and necroptosis through cyclin-dependent kinase 2-associated protein 1 (CDK2AP1). miR-21 expression increased in the liver of primary biliary cholangitis (PBC) patients and BDL wild-type (WT) mice at both 3 and 14 days. Notably, under BDL, miR-21 -/- mice displayed decreased liver injury markers in serum compared with WT mice, accompanied by reduced hepatocellular degeneration, oxidative stress and fibrosis. Hallmarks of necroptosis were decreased in the liver of BDL miR-21 -/- mice, via relieved repression of CDK2AP1. Further, miR-21 -/- mice displayed improved adaptive response of bile acid homeostasis. In conclusion, miR-21 ablation ameliorates liver damage and necroptosis in BDL mice. Inhibition of miR-21 should arise as a promising approach to treat cholestasis.info:eu-repo/semantics/publishedVersio

Rapid incision of the Mekong River in the middle Miocene linked to monsoonal precipitation

The uplift of orogenic plateaus has been assumed to be coincident with the fluvial incision of the gorges that commonly cut plateau margins. The Mekong River, which drains the eastern Qiangtang Terrane and southeastern Tibetan Plateau, is one of the ten largest rivers in the world by water and sediment discharge. When the Mekong River was established remains highly debated—with estimates that range from more than 55 to less than 5 million years ago—despite being a key constraint on the elevation history of the Tibetan Plateau. Here we report low-temperature thermochronology data from river bedrock samples that reveal a phase of rapid downward incision (>700 m) of the Mekong River during the middle Miocene about 17 million years ago, long after the uplift of the central and southeastern Tibetan Plateau. However, this coincides with a period of enhanced East Asian summer monsoon precipitation over the region compared with the early Miocene. Using stream profile modelling, we demonstrate that such an increase in precipitation could have produced the observed incision in the Mekong River. In the absence of an obvious tectonic contribution, we suggest that the rapid incision of the Tibetan Plateau and the establishment of the Mekong River in the middle Miocene may be attributed to increased erosion during a period of high monsoon precipitation

Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c

Multiplicities of charged hadrons produced in deep inelastic muon scattering off a 6LiD target have been measured as a function of the DIS variables xBj , Q2, W2 and the final state hadron variables pT and z. The p2T distributions are fitted with a single exponential function at low values of p2T to determine the dependence of 〈p2T 〉 on xBj , Q2, W2 and z. The z-dependence of 〈p2T 〉 is shown to be a potential tool to extract the average intrinsic transverse momentum squared of partons, 〈k2⊥〉, as a function of xBj and Q2 in a leading order QCD parton model

Hadron transverse momentum distributions in muon deep inelastic scattering at 160 GeV/c

Multiplicities of charged hadrons produced in deep inelastic muon scattering off a LiD target have been measured as a function of the DIS variables x , Q , W and the final state hadron variables p and z. The p distributions are fitted with a single exponential function at low values of p to determine the dependence of 〈p 〉 on x , Q , W and z. The z-dependence of 〈p 〉 is shown to be a potential tool to extract the average intrinsic transverse momentum squared of partons, 〈k 〉, as a function of x and Q in a leading order QCD parton model. 6 2 2 2 2 2 2 2 2 2 2 Bj T T T T Bj T ⊥ B