AMI-CL J0300+2613: a Galactic anomalous-microwave-emission ring masquerading as a galaxy cluster

Large scale structure and cosmolog

Review of the efficacy and safety of over-the-counter medicine

Over-the-counter medicines are available without prescription because of their safety and effectiveness, to treat minor ailments and symptoms. The objective of the study was to analyze the availability and quality of systematic reviews published about nonprescription medicines, identifying the groups for which there are gaps in evidence. We identified published articles through the Cochrane Database of Systematic Review and MEDLINE, from the start of the database until May 2012, using the search terms "nonprescription drugs," "over the counter," and "OTC." We searched for articles that describe systematic reviews addressing the efficacy and safety of drugs dispensed without a prescription, according to the lists published by the Association of the European Self-Medication Industry and in Brazil, in the clinical conditions listed in Groups and Specified Therapeutic Indications. We included 49 articles, 18 articles were of moderate quality and 31 of high quality. Of the studies, 74.5% demonstrated efficacy in favor of the use of drugs evaluated. Of the 24 studies that evaluated safety, 21% showed evidence unfavorable to the drug. Overall, the evidence found in the studies included in the overview is favorable to the use of the drugs evaluated. However, there are gaps in evidence for some therapy groups.</p

Anatomical Suitability For Endovascular AAA Repair May Affect Outcomes following Rupture

AbstractObjectivesSingle centre series have suggested that endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysms (rAAA) may reduce mortality versus open surgery. This has not been substantiated in the only randomized controlled trial, leading to suggestion that anatomical suitability for rEVAR may independently improve prognosis of rAAA. Our aim was to assess the outcome of open rAAA repair in patients dependant on their suitability for rEVAR on pre-operative computed tomography (CT) assessment.MethodsA retrospective review of all ruptured aneurysms presenting to our unit since January 1998 was performed. Patients were grouped based on anatomical suitability for rEVAR by pre-operative CT.ResultsOf 118 patients presenting with rAAA, 48 underwent pre-operative CT. Of these 9 scans had been “culled” and were excluded. 16 patients were suitable for rEVAR and 23 unsuitable. The groups were well matched demographically with no difference in Glasgow Aneurysm Score between groups. There was a non-significant trend towards reduction in 30-day mortality for patients suitable for EVAR (suitable 6.9% versus unsuitable 30.4%; P = 0.066) with no difference in operative time, transfusion requirement, length of stay or in-hospital morbidity.ConclusionsAnatomical suitability for EVAR seems to beneficially affect outcome following open repair for ruptured AAA. Further study is required to confirm these findings

Biological and biochemical quality of pastoral soils: spatial and temporal variability

This paper reports results of the first year of soil biochemical and microbiological monitoring programme carried out to establish "normal" ranges of values for these soil attributes. Study was conducted on 24 farm sites on yellow-brown loam soils around the Waikato area. Twelve dairy farms and a similar number of sheep-beef farms were selected on the basis of high productivity. Soil samples (0-75 mm depth) were collected at 3- monthly intervals and the following measurements were carried out: soil microbial- C, N, S and P, CO2 evolution, substrate-induced respiration, anaerobic mineralisable N, dehydrogenase activity, fluorescein diacetate (FDA) hydrolysis, amounts of soluble-C and N, extractable NO3 and NH4, soil pH, Olsen P, KH2PO4 extractable SO4-S and organic S, and hydraulic conductivity. Climatic data, records of fertiliser and other additives and productivity were also collected to interpret the variations in these properties. Variables measured from the Horotiu and Tirau silt loam soils showed considerable similarity, however, Otorohanga soils had significantly higher amounts of total and extractable soil C and N. As expected, being a higher input system, soil nutrient status (P, SO4, NO3 and NH4) on dairy farms was generally higher than the sheep-beef farms. The most significant difference was for the Olsen P values, which were about 60-70% higher under dairying. Soil pH on dairy farms was significantly higher than sheep- beef farms. However, total C and N values were significantly higher under sheep-beef than dairy farms. Similarly, the amounts of mineralisable N in all seasons were much higher for the sheep-beef than dairy farms. Apart from total microbial S, none of the other microbial biomass measurements showed any significant effect of season or difference among the soil types. This lack of seasonal effect on microbial biomass can be attributed to the unusual mild seasonal variation during the study. For the various microbial biomass measurements, sheep-beef farms generally had significantly higher values than dairy farms. Microbial C, N, SO4 and total S values were significantly higher for sheep-beef than dairying. The ratios between soil C, N to microbial C, N and microbial C:N showed no consistent pattern between the farm types. Keywords: C and N, enzyme activity, microbial biomass, seasonal variations, soil fertility</jats:p