Roles of glial cells in synapse development

Brain function relies on communication among neurons via highly specialized contacts, the synapses, and synaptic dysfunction lies at the heart of age-, disease-, and injury-induced defects of the nervous system. For these reasons, the formation—and repair—of synaptic connections is a major focus of neuroscience research. In this review, I summarize recent evidence that synapse development is not a cell-autonomous process and that its distinct phases depend on assistance from the so-called glial cells. The results supporting this view concern synapses in the central nervous system as well as neuromuscular junctions and originate from experimental models ranging from cell cultures to living flies, worms, and mice. Peeking at the future, I will highlight recent technical advances that are likely to revolutionize our views on synapse–glia interactions in the developing, adult and diseased brain

Associations between maternal child rearing cognitions and conduct problems in young children

This study investigated maternal childrearing cognitions associated with ineffec-tive parenting practices, using the Parental Childrearing Cognitions Questionnaire (PCCQ). Intergenerational transmission of parenting problems and cognitions was investigated using the Parental Bonding Instrument (PBI), which measures over-protectiveness and care experienced by parents in childhood. As a new measure, the PCCQ’s psychometric properties were evaluated and found to be robust in terms of internal consistency and test–retest reliability. Seventy-four mothers of 3–5-year-old boys (23 clinical: boys referred with conduct problems; 51 control) completed the PCCQ, Revised Rutter Parent Scale for Preschool Children and PBI. PCCQ scores were significantly higher for clinical group mothers, and signifi-cantly correlated with both Parent and Teacher Rutter Child problem scores. There were significant correlations between PBI overprotection (positive) and PBI care (negative) scores and Rutter Parent and PCCQ scores. Clinical group mothers rated lower care and higher overprotection, from both parents, in their own child-hoods. Results are consistent with a hypothesized model of intergenerationa