6,141 research outputs found
Ludic literacies at the intersections of cultures: an interview with James Paul Gee
Professor James Gee addresses issues of linguistics, literacies and cultures. Gee emphasises the importance of Discourses, and argues that the future of literacy studies lies in the interrogation of new media and the globalisation of culture
Experimental Performance of a Solar Air Collector with a Perforated Back Plate in New Zealand
Publishe
Pulsed Laser Interactions with Space Debris: Target Shape Effects
Among the approaches to the proposed mitigation and remediation of the space
debris problem is the de-orbiting of objects in low Earth orbit through
irradiation by ground-based high-intensity pulsed lasers. Laser ablation of a
thin surface layer causes target recoil, resulting in the depletion of orbital
angular momentum and accelerated atmospheric re-entry. However, both the
magnitude and direction of the recoil are shape dependent, a feature of the
laser-based remediation concept that has received little attention. Since the
development of a predictive capability is desirable, we have investigated the
dynamical response to ablation of objects comprising a variety of shapes. We
derive and demonstrate a simple analytical technique for calculating the
ablation-driven transfer of linear momentum, emphasizing cases for which the
recoil is not exclusively parallel to the incident beam. For the purposes of
comparison and contrast, we examine one case of momentum transfer in the
low-intensity regime, where photon pressure is the dominant momentum transfer
mechanism, showing that shape and orientation effects influence the target
response in a similar, but not identical, manner. We address the related
problem of target spin and, by way of a few simple examples, show how ablation
can alter the spin state of a target, which often has a pronounced effect on
the recoil dynamics.Comment: 51 pages, 14 figures, to appear in Advances in Space Researc
Removing Orbital Debris with Lasers
Orbital debris in low Earth orbit (LEO) are now sufficiently dense that the
use of LEO space is threatened by runaway collisional cascading. A problem
predicted more than thirty years ago, the threat from debris larger than about
1 cm demands serious attention. A promising proposed solution uses a high power
pulsed laser system on the Earth to make plasma jets on the objects, slowing
them slightly, and causing them to re-enter and burn up in the atmosphere. In
this paper, we reassess this approach in light of recent advances in low-cost,
light-weight modular design for large mirrors, calculations of laser-induced
orbit changes and in design of repetitive, multi-kilojoule lasers, that build
on inertial fusion research. These advances now suggest that laser orbital
debris removal (LODR) is the most cost-effective way to mitigate the debris
problem. No other solutions have been proposed that address the whole problem
of large and small debris. A LODR system will have multiple uses beyond debris
removal. International cooperation will be essential for building and operating
such a system.Comment: 37 pages, 15 figures, in preparation for submission to Advances in
Space Researc
The Changing Occupational Distribution by College Major
In this paper we examine the occupational distribution of individuals who hold bachelor degrees in particular fields in the United States using data from the various waves of the National Survey of College Graduates. We propose and calculate indexes that describe two related aspects of the occupational distribution by major field of study: distinctiveness (how dissimilar are the occupations of a particular major when compared with all other majors) and variety (how varied are the occupations among those who hold that particular major). We discuss theoretical properties of these indices and statistical properties of their estimates. We show that the occupational variety has increased since 1993 for most major fields of study, particularly between the 1993 and 2003 waves of the survey. We explore reasons for this broadening of the occupation distribution. We find that this has not led to an increase in reported mismatch between degree and occupation
Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate
Summary
One year of high-dose bisphosphonate (BPs) therapy in dogs allowed the increased accumulation of advanced glycation end-products (AGEs) and reduced postyield work-to-fracture of the cortical bone matrix. The increased accumulation of AGEs in these tissues may help explain altered bone matrix quality due to the administration of BPs in animal models
Introduction
Non-enzymatic glycation (NEG) is a posttranslational modification of the organic matrix that results in the formation of advanced glycation end-products (AGEs). In bone, the accumulation of AGEs play an important role in determining fracture resistance, and elevated levels of AGEs have been shown to adversely affect the bone’s propensity to brittle fracture. It was thus hypothesized that the suppression of tissue turnover in cortical bone due to the administration of bisphosphonates would cause increased accumulation of AGEs and result in a more brittle bone matrix.
Methods
Using a canine animal model (n = 12), we administered daily doses of a saline vehicle (VEH), alendronate (ALN 0.20, 1.00 mg/kg) or risedronate (RIS 0.10, 0.50 mg/kg). After a 1-year treatment, the mechanical properties, intracortical bone turnover, and the degree of nonenzymatic cross-linking of the organic matrix were measured from the tibial cortical bone tissue of these animals.
Results
There was a significant accumulation of AGEs at high treatment doses (+49 to + 86%; p < 0.001), but not at doses equivalent to those used for the treatment of postmenopausal osteoporosis, compared to vehicle. Likewise, postyield work-to-fracture of the tissue was significantly reduced at these high doses (−28% to −51%; p < 0.001) compared to VEH. AGE accumulation inversely correlated with postyield work-to-fracture (r 2 = 0.45; p < 0.001), suggesting that increased AGEs may contribute to a more brittle bone matrix.
Conclusion
High doses of bisphosphonates result in the accumulation of AGEs and a reduction in energy absorption of cortical bone. The increased accumulation of AGEs in these tissues may help explain altered bone matrix quality due to the administration of BPs in animal models
Autofluorescence lifetime augmented reality as a means for real-time robotic surgery guidance in human patients.
Due to loss of tactile feedback the assessment of tumor margins during robotic surgery is based only on visual inspection, which is neither significantly sensitive nor specific. Here we demonstrate time-resolved fluorescence spectroscopy (TRFS) as a novel technique to complement the visual inspection of oral cancers during transoral robotic surgery (TORS) in real-time and without the need for exogenous contrast agents. TRFS enables identification of cancerous tissue by its distinct autofluorescence signature that is associated with the alteration of tissue structure and biochemical profile. A prototype TRFS instrument was integrated synergistically with the da Vinci Surgical robot and the combined system was validated in swine and human patients. Label-free and real-time assessment and visualization of tissue biochemical features during robotic surgery procedure, as demonstrated here, not only has the potential to improve the intraoperative decision making during TORS but also other robotic procedures without modification of conventional clinical protocols
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