Wikipedia as an encyclopaedia of life

In his 2003 essay E O Wilson outlined his vision for an “encyclopaedia of life” comprising “an electronic page for each species of organism on Earth”, each page containing “the scientific name of the species, a pictorial or genomic presentation of the primary type specimen on which its name is based, and a summary of its diagnostic traits.” Although the “quiet revolution” in biodiversity informatics has generated numerous online resources, including some directly inspired by Wilson's essay (e.g., "http://ispecies.org":http://ispecies.org, "http://www.eol.org":http://www.eol.org), we are still some way from the goal of having available online all relevant information about a species, such as its taxonomy, evolutionary history, genomics, morphology, ecology, and behaviour. While the biodiversity community has been developing a plethora of databases, some with overlapping goals and duplicated content, Wikipedia has been slowly growing to the point where it now has over 100,000 pages on biological taxa. My goal in this essay is to explore the idea that, largely independent of the efforts of biodiversity informatics and well-funded international efforts, Wikipedia ("http://en.wikipedia.org/wiki/Main_Page":http://en.wikipedia.org/wiki/Main_Page) has emerged as potentially the best platform for fulfilling E O Wilson’s vision

Simulating weathering of basalt on Mars and Earth by thermal cycling

Physical weathering induced by heating and cooling may cause rock breakdown on Mars and Earth. We report results from parallel weathering simulations on basalt blocks exposed to diurnal cycles representing Mars-like (two simulation runs from −55 to +20 oC and −75 to +10 oC, 1–100% relative humidity, 4–8 mbar pressure, CO_2 atmosphere) and hot arid Earth (23–72o C, 30–100% relative humidity) conditions. Under Earth conditions, thermally pre-stressed blocks showed measurable strength declines, whilst salt pre-treated blocks showed strength gains. Under Mars-like conditions, pre-stressed blocks recorded greater or similar strength declines and salt pre-treated blocks showed more muted strength declines than under Earth conditions. The results imply that on Earth and Mars diurnal cycling of temperature alone can cause deterioration of basalt with a pre-existing stress history. The type of stress history is important, with salt pre-treatment affecting the response of thermally pre-stressed blocks under both Earth and Mars conditions

Text and Transmission

The modern reader may encounter the Greek text of Euripides' surviving plays in many forms: in print either in complete editions or in separate editions of single plays published with translations or commentaries or both, and in digital form at well-known sites on the internet. When Euripides composed his plays, he is most likely to have written on a papyrus roll, although for rough drafts of small sections he could have used wax tablets, loose papyrus sheets, or pottery sherds. Although the papyrus rolls and early codices give us intriguing glimpses of the text of the Euripides plays up the seventh century CE, the surviving complete plays depend on the medieval textual tradition. For Euripides as for Aeschylus and Sophocles, Alexandrian scholars collected texts of as many plays as they could, comparing their titles to those known from the didascalic records. About seventy plays of Euripides never reached the medieval manuscript tradition

The Fourth Law of Black Hole Thermodynamics

We show that black holes fulfill the scaling laws arising in critical transitions. In particular, we find that in the transition from negative to positive values the heat capacities $C_{JQ}$, $C_{\Omega Q}$ and $C_{J\Phi}$ give rise to critical exponents satisfying the scaling laws. The three transitions have the same critical exponents as predicted by the universality Hypothesis. We also briefly discuss the implications of this result with regards to the connections among gravitation, quantum mechanics and statistical physics.Comment: 19 pages (two figures), Plain Tex. Preprint KONS-RGKU-93-11. To appear in Nucl. Phys. B (1993

Greenhouse gas emission factors associated with rewetting of organic soils

Drained organic soils are a significant source of greenhouse gas (GHG) emissions to the atmosphere. Rewetting these soils may reduce GHG emissions and could also create suitable conditions for return of the carbon (C) sink function characteristic of undrained organic soils. In this article we expand on the work relating to rewetted organic soils that was carried out for the 2014 Intergovernmental Panel on Climate Change (IPCC) Wetlands Supplement. We describe the methods and scientific approach used to derive the Tier 1 emission factors (the rate of emission per unit of activity) for the full suite of GHG and waterborne C fluxes associated with rewetting of organic soils. We recorded a total of 352 GHG and waterborne annual flux data points from an extensive literature search and these were disaggregated by flux type (i.e. CO2, CH4, N2O and DOC), climate zone and nutrient status. Our results showed fundamental differences between the GHG dynamics of drained and rewetted organic soils and, based on the 100 year global warming potential of each gas, indicated that rewetting of drained organic soils leads to: net annual removals of CO2 in the majority of organic soil classes; an increase in annual CH4 emissions; a decrease in N2O and DOC losses; and a lowering of net GHG emissions. Data published since the Wetlands Supplement (n = 58) generally support our derivations. Significant data gaps exist, particularly with regard to tropical organic soils, DOC and N2O. We propose that the uncertainty associated with our derivations could be significantly reduced by the development of country specific emission factors that could in turn be disaggregated by factors such as vegetation composition, water table level, time since rewetting and previous land use history

New CMB Power Spectrum Constraints from MSAMI

We present new cosmic microwave background (CMB) anisotropy results from the combined analysis of the three flights of the first Medium Scale Anisotropy Measurement (MSAM1). This balloon-borne bolometric instrument measured about 10 square degrees of sky at half-degree resolution in 4 frequency bands from 5.2 icm to 20 icm with a high signal-to-noise ratio. Here we present an overview of our analysis methods, compare the results from the three flights, derive new constraints on the CMB power spectrum from the combined data and reduce the data to total-power Wiener-filtered maps of the CMB. A key feature of this new analysis is a determination of the amplitude of CMB fluctuations at $\ell \sim 400$. The analysis technique is described in a companion paper by Knox.Comment: 9 pages, 6 included figure

Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR ser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy

Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial. The effects of continuous or pulsed T stimulation were tested in vitro and in vivo on androgen-sensitive Pca cell lines in order to assess the differential biological properties of these two treatment modalities. Pulsed T treatment resulted in a greater inhibition than continuous T supplementation of tumor growth in vitro and in vivo. The effects of pulsed T treatment on tumor growth inhibition, G0/G1 cell cycle arrest, and tumor senescence was more pronounced than those obtained upon continuous T treatments. Mechanistic studies revealed that G0/G1 arrest and tumor senescence upon pulsed T treatment were associated with a marked decrease in cyclin D1, c-Myc and SKp2, CDK4 and p-Rb levels and upregulation of p27 and p-ERK1/2. Pulsed, but not continuous, T supplementation decreased the expression levels of AR, p-AR ser81 and CDK1 in both cellular models. The in vitro results were confirmed in an in vivo xenografts, providing evidence of a greater inhibitory activity of pulsed supraphysiological T supplementation than continuous treatment, both in terms of tumor volume and decreased AR, p-AR ser81 , PSA and CDK1 staining. The rapid cycling from hypogonadal to physiological or supra-physiological T intraprostatic concentrations results in cytostatic and senescence effects in preclinical models of androgen-sensitive Pca. Our preclinical evidence provides relevant new insights in the biology of Pca response to pulsed T supplementation

A systematic literature review of undergraduate clinical placements in underserved areas.

Context: The delivery of undergraduate clinical education in underserved areas is increasing in various contexts across the world in response to local workforce needs. A collective understanding of the impact of these placements is lacking. Previous reviews have often taken a positivist approach by only looking at outcome measures. This review addresses the question: What are the strengths and weaknesses for medical students and supervisors of community placements in underserved areas? Methods: A systematic literature review was carried out by database searching, citation searching, pearl growing, reference list checking and use of own literature. The databases included MEDLINE, EMBASE, PsycINFO, Web of Science and ERIC. The search terms used were combinations and variations of four key concepts exploring general practitioner (GP) primary care, medical students, placements and location characteristics. The papers were analysed using a textual narrative synthesis. Findings: The initial search identified 4923 results. After the removal of duplicates and the screening of titles and abstracts, 185 met the inclusion criteria. These full articles were obtained and assessed for their relevance to the research question; 54 were then included in the final review. Four main categories were identified: student performance, student perceptions, career pathways and supervisor experiences. Conclusions: This review reflects the emergent qualitative data as well as the quantitative data used to assess initiatives. Underserved area placements have produced many beneficial implications for students, supervisors and the community. There is a growing amount of evidence regarding rural, underserved areas, but little in relation to inner city, deprived areas, and none in the UK

Are there valid proxy measures of clinical behaviour?

Background: Accurate measures of health professionals' clinical practice are critically important to guide health policy decisions, as well as for professional self-evaluation and for research-based investigation of clinical practice and process of care. It is often not feasible or ethical to measure behaviour through direct observation, and rigorous behavioural measures are difficult and costly to use. The aim of this review was to identify the current evidence relating to the relationships between proxy measures and direct measures of clinical behaviour. In particular, the accuracy of medical record review, clinician self-reported and patient-reported behaviour was assessed relative to directly observed behaviour. Methods: We searched: PsycINFO; MEDLINE; EMBASE; CINAHL; Cochrane Central Register of Controlled Trials; science/social science citation index; Current contents (social & behavioural med/clinical med); ISI conference proceedings; and Index to Theses. Inclusion criteria: empirical, quantitative studies; and examining clinical behaviours. An independent, direct measure of behaviour (by standardised patient, other trained observer or by video/audio recording) was considered the 'gold standard' for comparison. Proxy measures of behaviour included: retrospective self-report; patient-report; or chart-review. All titles, abstracts, and full text articles retrieved by electronic searching were screened for inclusion and abstracted independently by two reviewers. Disagreements were resolved by discussion with a third reviewer where necessary. Results: Fifteen reports originating from 11 studies met the inclusion criteria. The method of direct measurement was by standardised patient in six reports, trained observer in three reports, and audio/video recording in six reports. Multiple proxy measures of behaviour were compared in five of 15 reports. Only four of 15 reports used appropriate statistical methods to compare measures. Some direct measures failed to meet our validity criteria. The accuracy of patient report and chart review as proxy measures varied considerably across a wide range of clinical actions. The evidence for clinician self-report was inconclusive. Conclusion: Valid measures of clinical behaviour are of fundamental importance to accurately identify gaps in care delivery, improve quality of care, and ultimately to improve patient care. However, the evidence base for three commonly used proxy measures of clinicians' behaviour is very limited. Further research is needed to better establish the methods of development, application, and analysis for a range of both direct and proxy measures of behaviour