Effective Interventions for Treating Superficial Self Mutilators

Self-cutting is the most common form of self-mutilation in adolescents but there is insufficient knowledge as to which treatment methods to reduce self-mutilation are most effective. This exploration into the causes of self-cutting and the treatment interventions, such as Dialectical Behavior Therapy (DBT), compares adolescents who had DBT treatment with those who have used other treatment methods. Research findings indicate that the average age of adolescents in treatment was 15 years old and had been in treatment at least one time prior. Adolescents in DBT treatment showed signs in reducing/stopping self-cutting behavior along with improving communication skills with caregivers. Implications of this study show the need for further research to help educate professionals about the effective treatment for treating adolescent self-cutters

Sovereign CDS and Bond Pricing Dynamics in the Euro-area

This analysis tests the price discovery relationship between sovereign CDS premia and bond yield spreads on the same reference entity. The theoretical no-arbitrage relationship between the two credit spreads is confronted with daily data from six Euro-area countries over the period 2004-2011. As a first step, the supposed non stationarity of the two series is verified. Then, we examine whether the non-stationary CDS and bond spreads series are bound by a cointegration relationship. Overall the cointegration analysis confirms that the two prices should be equal to each other in equilibrium, as theory predicts. Nonetheless the theoretical value [1, -1] for the cointegrating vector is rejected, meaning that in the short run the cash and synthetic market's valuation of credit risk differ to various degrees. The VECM analysis suggests that the CDS market moves ahead of the bond market in terms of price discovery. These findings are further supported by the Granger Causality Test: for most sovereigns in the sample, past values of CDS spreads help to forecast bond yield spreads. Short-run deviations from the equilibrium persist longer than it would take for participants in one market to observe the price in the other. That is consistent with the hypothesis of imperfections in the arbitrage relationship between the two markets.

Evaluation of the N Latex free light chain assay in the diagnosis and monitoring of AL amyloidosis

Background: We compared a novel assay for free light chain (FLC) quantitation based on monoclonal antibodies (N-Latex, Siemens, Germany) to the established polyclonal antibody-based assay (Freelite (TM), The Binding Site, UK) in AL amyloidosis

Tecnologia para aplicação de produtos fitossanitários em videira.

Por definição a tecnologia de Aplicação não se resume ao ato de apenas aplicar o produto, mas na interação de fatores, que buscam a máxima eficiência dos tratamentos, economicidade, eficiência operacional, adequação de máquinas e menor contaminação ambiental e segurança do operador (MATTHEWS,1992). Para tanto, aspectos como o ambiente, qualidade da pulverização promovida pelas pontas de pulverização em função do padrão de gotas produzidas, se interrelacionam e são determinantes para o sucesso das aplicações na cultura da videira, que é cultivada no Brasil em diferentes regiões e conseqüentemente diversificadas em relação ao aspecto climático que confere severidade diferenciada da principal doença infecciosa da cultura, o míldio; sendo necessário de 15 a 50 aplicações por ano para regiões de clima temperado e tropical respectivamente ou também por características varietais que conferem à videira diferentes níveis de suscetibilidade.bitstream/CNPUV/8821/1/cir073.pd

Policultivo de amaranto con leguminosas, una alternativa de manejo agroecológico de malezas para agricultores familiares de la provincia de Buenos Aires

La necesidad de un sistema agropecuario más sustentable, ecológicamente adecuado, y socialmente aceptable, que provea una alimentación variada y de calidad, es hoy una realidad en la Provincia de Buenos Aires. El cultivo del amaranto (Amaranthus sp.), alimento altamente nutritivo y con gran potencial para adaptarse a las condiciones agroecológicas de la provincia de Buenos Aires, es una posibilidad. Una de sus dificultades es el control de malezas sin uso de agroquímicos. El objetivo de este trabajo es evaluar, desde un enfoque agroecológico, el uso de policultivos con leguminosas (Vicia villosa y Trifolium pratense), como alternativa a dicho problema. Los resultados de esta experiencia muestran que el amaranto y las leguminosas, al ocupar nichos ecológicos distintos, no presentan fuerte competencia entre sí y, por lo tanto, la siembra de Vicia villosa con amaranto aparece como una estrategia adecuada para el manejo ecológico de malezas para agricultores familiares de la provincia de Buenos Aires.The need of agricultural system more sustainable, ecologically suitable and aceptable socially, that provides varied and quality alimentation, is now the reality of Province of Buenos Aires. The crop amaranth incorporation (Amaranthus sp.), very nutritious food and with great potential to suit the agro-ecological conditions of the province of Buenos Aires, is a posibility. one of the difficulties is to control weeds without using chemicals. The aim of this study is to evaluate , from an agro-ecological approach , using intercropping with legumes (Vicia villosa and Trifolium pratense), as an alternative to this problem.The results from that experience show that the amaranth and the legumes, occupy differents niches, no significant competition between them, so, the planting of vicia villosa and amaranth appear like suitable strategy to do an ecological management of weeds for family farmers from Province of Buenos Aires.Eje: A1: Sistemas de producción de base agroecológic

Policultivo de amaranto con leguminosas, una alternativa de manejo agroecológico de malezas para agricultores familiares de la provincia de Buenos Aires

La necesidad de un sistema agropecuario más sustentable, ecológicamente adecuado, y socialmente aceptable, que provea una alimentación variada y de calidad, es hoy una realidad en la Provincia de Buenos Aires. El cultivo del amaranto (Amaranthus sp.), alimento altamente nutritivo y con gran potencial para adaptarse a las condiciones agroecológicas de la provincia de Buenos Aires, es una posibilidad. Una de sus dificultades es el control de malezas sin uso de agroquímicos. El objetivo de este trabajo es evaluar, desde un enfoque agroecológico, el uso de policultivos con leguminosas (Vicia villosa y Trifolium pratense), como alternativa a dicho problema. Los resultados de esta experiencia muestran que el amaranto y las leguminosas, al ocupar nichos ecológicos distintos, no presentan fuerte competencia entre sí y, por lo tanto, la siembra de Vicia villosa con amaranto aparece como una estrategia adecuada para el manejo ecológico de malezas para agricultores familiares de la provincia de Buenos Aires.The need of agricultural system more sustainable, ecologically suitable and aceptable socially, that provides varied and quality alimentation, is now the reality of Province of Buenos Aires. The crop amaranth incorporation (Amaranthus sp.), very nutritious food and with great potential to suit the agro-ecological conditions of the province of Buenos Aires, is a posibility. one of the difficulties is to control weeds without using chemicals. The aim of this study is to evaluate , from an agro-ecological approach , using intercropping with legumes (Vicia villosa and Trifolium pratense), as an alternative to this problem.The results from that experience show that the amaranth and the legumes, occupy differents niches, no significant competition between them, so, the planting of vicia villosa and amaranth appear like suitable strategy to do an ecological management of weeds for family farmers from Province of Buenos Aires.Eje: A1: Sistemas de producción de base agroecológic

Rationale, application and clinical qualification for NT-proBNP as a surrogate end point in pivotal clinical trials in patients with AL amyloidosis

Amyloid light-chain (LC) amyloidosis (AL amyloidosis) is a rare and fatal disease for which there are no approved therapies. In patients with AL amyloidosis, LC aggregates progressively accumulate in organs, resulting in organ failure that is particularly lethal when the heart is involved. A significant obstacle in the development of treatments for patients with AL amyloidosis, as well as for those with any disease that is rare, severe and heterogeneous, has been satisfying traditional clinical trial end points (for example, overall survival or progression-free survival). It is for this reason that many organizations, including the United States Food and Drug Administration through its Safety and Innovation Act Accelerated Approval pathway, have recognized the need for biomarkers as surrogate end points. The international AL amyloidosis expert community is in agreement that the N-terminal fragment of the pro-brain natriuretic peptide (NT-proBNP) is analytically validated and clinically qualified as a biomarker for use as a surrogate end point for survival in patients with AL amyloidosis. Underlying this consensus is the demonstration that NT-proBNP is an indicator of cardiac response in all interventional studies in which it has been assessed, despite differences in patient population, treatment type and treatment schedule. Furthermore, NT-proBNP expression is directly modulated by amyloidogenic LC-elicited signal transduction pathways in cardiomyocytes. The use of NT-proBNP will greatly facilitate the development of targeted therapies for AL amyloidosis. Here, we review the data supporting the use of NT-proBNP, a biomarker that is analytically validated, clinically qualified, directly modulated by LC and universally accepted by AL amyloidosis specialists, as a surrogate end point for survival.Leukemia advance online publication, 2 August 2016; doi:10.1038/leu.2016.191