Effect of 1.5 MeV electron irradiation on the transmission of optical materials

Comparison of 1.5 MeV electron irradiation induced optical absorption of fused commercial silicas and optical transmission of Al2O3, MgF2, BaF2, LiF, and Be

Promoting a local brand: Assessing the Economic Benefits of the Texas Superstar® and Earth-Kind® Promotion on Place (POP) Program

This paper aims to evaluate consumer’s awareness and willingness-to-pay (WTP) for two ornamental brands in Texas: Texas Superstar® and Earth-Kind®, after a Promotion on Place (POP) Program was developed by the Texas Department of Agriculture (TDA). Consumer’s characteristics that are more likely to influence brand awareness and WTP are identified.Brand recognition, Willingness to pay, Consumer preferences, Ornamentals, Consumer/Household Economics, Marketing,

Complex-type numbers and generalizations of the Euler identity

We consider different generalizations of the Euler formula and discuss the properties of the associated trigonometric functions. The problem is analyzed from different points of view and it is shown that it can be formulated in a natural way in algebraic and geometric terms.Comment: 10 page

Technology Adoption in Nonrenewable Resource Management

Nonrenewable resource scarcity has been a traditional concern when designing optimal growth models. Technological change has played an important role in those models, since its presence is assumed to mitigate the depletion effect on extraction paths over time. We formalize the general problem of a competitive nonrenewable resource extracting firm to analyze optimal extraction behavior and technology adoption when adoption is costly, both in a deterministic and a stochastic environment, when the firm either anticipates adoption or not. Based on a quadratic extraction cost function, our results do not support the traditional view according to which the firm will only incur in an adoption cost when the stock is depleted enough.nonrenewable resources; technology adoption; depletion effect; cost of adoption.

Physical activity programs for balance and fall prevention in elderly: A systematic review

BACKGROUND: Due to demographic changes the world's population is progressively ageing. The physiological decay of the elderly adult may lead to a reduction in the ability to balance and an increased risk of falls becoming an important issue among the elderly. In order to counteract the decay in the ability to balance, physical activity has been proven to be effective. The aim of this study is to systematically review the scientific literature in order to identify physical activity programs able to increase balance in the elderly. METHODS: This review is based on the data from Medline-NLM, Pubmed, ScienceDirect, and SPORTDiscuss and includes randomized control trials that have analyzed balance and physical activity in healthy elderly over 65 years of age during the last decade. A final number of 8 manuscripts were included in the qualitative synthesis, which comprised 200 elderly with a mean age of 75.1 ± 4.4 years. The sample size of the studies varied from 9 to 61 and the intervention periods from 8 to 32 weeks. RESULTS: Eight articles were considered eligible and included in the quantitative synthesis. The articles investigated the effects of resistance and aerobic exercise, balance training, T-bow© and wobble board training, aerobic step and stability ball training, adapted physical activity and Wii Fit training on balance outcomes. Balance measures of the studies showed improvements between 16% and 42% compared to baseline assessments. CONCLUSIONS: Balance is a multifactorial quality that can be effectively increased by different exercise training means. It is fundamental to promote physical activity in the aging adult, being that a negative effect on balance performance has been seen in the no-intervention control groups

La promenade, un outil de connaissance du territoire.

Walking is an act of the body most of us perform. In the shape of strolls and shared itineraries it can be used as a different way of considering our surrounding territory. As a simple act including rich content and relationships, the individual can thus evolve in his relationship with himself, the others and spaceLa marche est une technique du corps partagée par le plus grand nombre. Déclinée sous forme de promenades et de parcours partagés, elle peut être envisagée pour appréhender le territoire autrement qu'à travers une grille fonctionnaliste. Acte simple dégageant une richesse de contenus et relations, la promenade place l'individu en relation à lui-même, à l'autre, et à l'espace

Cannabinoids in the treatment of epilepsy: current status and future prospects

Cannabidiol (CBD) is one of the prominent phytocannabinoids found in Cannabis sativa, differentiating from Δ9-tetrahydrocannabinol (THC) for its non-intoxicating profile and its antianxiety/antipsychotic effects. CBD is a multi-target drug whose anti-convulsant properties are supposed to be independent of endocannabinoid receptor CB1 and might be related to several underlying mechanisms, such as antagonism on the orphan GPR55 receptor, regulation of adenosine tone, activation of 5HT1A receptors and modulation of calcium intracellular levels. CBD is a lipophilic compound with low oral bioavailability (6%) due to poor intestinal absorption and high first-pass metabolism. Its exposure parameters are greatly influenced by feeding status (ie, high fatcontaining meals). It is mainly metabolized by cytochrome P 450 (CYP) 3A4 and 2C19, which it strongly inhibits. A proprietary formulation of highly purified, plant-derived CBD has been recently licensed as an adjunctive treatment for Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), while it is being currently investigated in tuberous sclerosis complex. The regulatory agencies’ approval was granted based on four pivotal double-blind, placebocontrolled, randomized clinical trials (RCTs) on overall 154 DS patients and 396 LGS ones, receiving CBD 10 or 20 mg/kg/day BID as active treatment. The primary endpoint (reduction in monthly seizure frequency) was met by both CBD doses. Most patients reported adverse events (AEs), generally from mild to moderate and transient, which mainly consisted of somnolence, sedation, decreased appetite, diarrhea and elevation in aminotransferase levels, the last being documented only in subjects on concomitant valproate therapy. The interaction between CBD and clobazam, likely due to CYP2C19 inhibition, might contribute to some AEs, especially somnolence, but also to CBD clinical effectiveness. Cannabidivarin (CBDV), the propyl analogue of CBD, showed anti-convulsant properties in pre-clinical studies, but a plant-derived, purified proprietary formulation of CBDV recently failed the Phase II RCT in patients with uncontrolled focal seizures

Spectroscopy of Giant Stars in the Pyxis Globular Cluster

The Pyxis globular cluster is a recently discovered globular cluster that lies in the outer halo (R_{gc} ~ 40 kpc) of the Milky Way. Pyxis lies along one of the proposed orbital planes of the Large Magellanic Cloud (LMC), and it has been proposed to be a detached LMC globular cluster captured by the Milky Way. We present the first measurement of the radial velocity of the Pyxis globular cluster based on spectra of six Pyxis giant stars. The mean heliocentric radial velocity is ~ 36 km/sec, and the corresponding velocity of Pyxis with respect to a stationary observer at the position of the Sun is ~ -191 km/sec. This radial velocity is a large enough fraction of the cluster's expected total space velocity, assuming that it is bound to the Milky Way, that it allows strict limits to be placed on the range of permissible transverse velocities that Pyxis could have in the case that it still shares or nearly shares an orbital pole with the LMC. We can rule out that Pyxis is on a near circular orbit if it is Magellanic debris, but we cannot rule out an eccentric orbit associated with the LMC. We have calculated the range of allowed proper motions for the Pyxis globular cluster that result in the cluster having an orbital pole within 15 degrees of the present orbital pole of the LMC and that are consistent with our measured radial velocity, but verification of the tidal capture hypothesis must await proper motion measurement from the Space Interferometry Mission or HST. A spectroscopic metallicity estimate of [Fe/H] = -1.4 +/- 0.1 is determined for Pyxis from several spectra of its brightest giant; this is consistent with photometric determinations of the cluster metallicity from isochrone fitting.Comment: 22 pages, 5 figures, aaspp4 style, accepted for publication in October, 2000 issue of the PAS