Vertical Dimension Control in Two Different Treatment Protocols: Invisalign First and Bite Block—A Retrospective Study

background: the aim of the present study was to compare the vertical dimension changes, before and after treatment, in two groups of growing patients, one group treated with clear aligner therapy versus a group treated with quad-helix and bite-block therapy. methods: the studied sample was composed of n. 40 patients (20 females and 20 males with a mean age of 8.6 ± 1.8 years), enrolled from the department of orthodontics at policlinico of rome tor vergata. the original sample was randomly divided into two groups: group IF (invisalign first) and group BB (quad-helix and bite block). pre- (T0) and post-treatment (T1 after 12 months) lateral cephalograms were collected from all the selected patients. nine cephalometric parameters, both angular and linear, were measured and recorded for each cephalogram. results: no statistically significant changes were found between both the IF and BB groups at T0, while statistically significant changes were observed in both groups (BB and IF) between T0 and T1 (after 12 months of active therapy), p < 0.005. conclusions: both therapies were able to control the patient’s vertical condition. to date, the use of conventional appliances seems to have slightly better efficacy in controlling the vertical dimension than aligner therapy

Synthesis of novel structural hybrids between aza-heterocycles and azelaic acid moiety with a specific activity on osteosarcoma cells

Nine compounds bearing pyridinyl (or piperidinyl, benzimidazolyl, benzotriazolyl) groups bound to an azelayl moiety through an amide bond were synthesized. The structural analogy with some histone deacetylase inhibitors inspired their syntheses, seeking new selective histone deacetylase inhibitors (HDACi). The azelayl moiety recalls part of 9-hydroxystearic acid, a cellular lipid showing antiproliferative activity toward cancer cells with HDAC as a molecular target. Azelayl derivatives bound to a benzothiazolyl moiety further proved to be active as HDACi. The novel compounds were tested on a panel of both normal and tumor cell lines. Non-specific induction of cytotoxicity was observed in the normal cell line, while three of them induced a biological effect only on the osteosarcoma (U2OS) cell line. One of them induced a change in nuclear shape and size. Cell-cycle alterations are associated with post-transcriptional modification of both H2/H3 and H4 histones. In line with recent studies, revealing unexpected HDAC7 function in osteoclasts, molecular docking studies on the active molecules predicted their proneness to interact with HDAC7. By reducing side effects associated with the action of the first-generation inhibitors, the herein reported compounds, thus, sound promising as selective HDACi

Multivariate statistical integration of satellite infrared and microwave radiometric measurements for rainfall retrieval at the geostationary scale

The objective of this paper is to investigate how the complementarity between low earth orbit (LEO) microwave (MW) and geostationary earth orbit (GEO) infrared (IR) radiometric measurements can be exploited for satellite rainfall detection and estimation. Rainfall retrieval is pursued at the space–time scale of typical geostationary observations, that is at a spatial resolution of few kilometers and a repetition period of few tens of minutes. The basic idea behind the investigated statistical integration methods follows an established approach consisting in using the satellite MW-based rain-rate estimates, assumed to be accurate enough, to calibrate spaceborne IR measurements on sufficiently limited subregions and time windows. The proposed methodologies are focused on new statistical approaches, namely the multivariate probability matching (MPM) and variance-constrained multiple regression (VMR). The MPM and VMR methods are rigorously formulated and systematically analyzed in terms of relative detection and estimation accuracy and computing efficiency. In order to demonstrate the potentiality of the proposed MW–IR combined rainfall algorithm (MICRA), three case studies are discussed, two on a global scale on November 1999 and 2000 and one over the Mediterranean area. A comprehensive set of statistical parameters for detection and estimation assessment is introduced to evaluate the error budget. For a comparative evaluation, the analysis of these case studies has been extended to similar techniques available in literature

How pain affect real life of children and adults with achondroplasia: a systematic review

The clinical features of achondroplasia can cause acute self-limited pain that can develop into chronic pain. Pain causes a low quality of life, in terms of physical, emotional, social, and school functioning in both adult and children with achondroplasia. We conducted a systematic review according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement to describe prevalence, assessment tools, causes and management strategies of pain in this rare disease. We found that shoulder and knee pain is typically referred during infancy, while knee pain is generally referred around 5-6 years of age. The prevalence of general pain in adolescence can be as high as 90%. Chronic pain in the achondroplasia population increases with age, with up to 70% of adults reporting general pain and back pain. Recognizing the multiple determinants of acute and chronic pain in patients with achondroplasia may enable physicians to better understand and manage this burden, particularly with the advent of new drugs that may modify some of the known features of achondroplasia

What to expect of feeding abilities and nutritional aspects in achondroplasia patients: a narrative review

Achondroplasia is an autosomal dominant genetic disease representing the most common form of human skeletal dysplasia: almost all individuals with achondroplasia have identifiable mutations in the fibroblast growth factor receptor type 3 (FGFR3) gene. The cardinal features of this condition and its inheritance have been well-established, but the occurrence of feeding and nutritional complications has received little prominence. In infancy, the presence of floppiness and neurological injury due to foramen magnum stenosis may impair the feeding function of a newborn with achondroplasia. Along with growth, the optimal development of feeding skills may be affected by variable interactions between midface hypoplasia, sleep apnea disturbance, and structural anomalies. Anterior open bite, prognathic mandible, retrognathic maxilla, and relative macroglossia may adversely impact masticatory and respiratory functions. Independence during mealtimes in achondroplasia is usually achieved later than peers. Early supervision of nutritional intake should proceed into adolescence and adulthood because of the increased risk of obesity and respiratory problems and their resulting sequelae. Due to the multisystem involvement, oral motor dysfunction, nutrition, and gastrointestinal issues require special attention and personalized management to facilitate optimal outcomes, especially because of the novel therapeutic options in achondroplasia, which could alter the progression of this rare disease