Rituximab-associated hypogammaglobulinemia in children with idiopathic nephrotic syndrome: results of an ESPN survey

Background: There is paucity of information on rituximab-associated hypogammaglobulinemia (HGG) and its potential infectious consequences in children treated for idiopathic nephrotic syndrome (INS). Methods: A survey was distributed by the European Society Pediatric Nephrology to its members. It addressed the screening and management practices of pediatric nephrology units for recognizing and treating RTX-associated HGG and its morbidity and mortality. Eighty-four centers which had treated an overall 1328 INS children with RTX responded. Results: The majority of centers administered several courses of RTX and continued concomitant immunosuppressive therapy. Sixty-five percent of centers routinely screened children for HGG prior to RTX infusion, 59% during, and 52% following RTX treatment. Forty-seven percent had observed HGG prior to RTX administration, 61% during and 47% >9 months following treatment in 121, 210, and 128 subjects respectively. Thirty-three severe infections were reported among the cohort of 1328 RTX-treated subjects, of whom 3 children died. HGG had been recognized in 30/33 (80%) of them. Conclusions: HGG in steroid-dependent/frequently relapsing nephrotic syndrome (SDNS/FRNS) children is probably multifactorial and can be observed prior to RTX administration in children with SDNS/FRNS. Persistent HGG lasting >9 months from RTX infusion is not uncommon and may increase the risk of severe infections in this cohort. We advocate for the obligatory screening for HGG in children with SDNS/FRNS prior to, during, and following RTX treatment. Further research is necessary to identify risk factors for developing both HGG and severe infections before recommendations are made for its optimal management

Efficiency of selection in O type lines of sugar beet to biological and agronomic properties

Celem pracy była identyfikacja samozgodnych roślin w 5 liniach typu O. Ogółem zaizolowano po 3 pędy na każdej z 200 wybranych roślin. Część roślin nie zawiązała nasion. Do dalszej selekcji wybrano tylko te rośliny, które zawiązały minimum 150 nasion. Wybrane rośliny S1 ponownie izolowano i otrzymano pokolenie S2. Większość roślin była prawie jednolita co do pokroju, wielkości nasion i gęstego osadzenia na pędach nasiennych. Najlepsze potomstwa S2 rozmnożono w 37 szkółkach chowu siostrzanego. Wartość wybranych 11 potomstw S2 (Fl S2) porównano w doświadczeniach polowych. Plon korzeni zmniejszył się i wynosił 75,2-91,8%, a zawartość cukru była niższa lub zbliżona do średniej wzorca.The aim of the study was to identify self-compatible plants in five O type lines. In all, 200 mother plants, three stalks per plant, were isolated in paper bags. A part of plants did not set any seeds. Only the plants which set at least 150 seeds were taken to further selection. Selected S1 plants were bagged again to obtain the S2 generation. In S2 generation the majority of plants were nearly homogenous as to the habitus, seed size and dense seed distribution on the stalks. Best progenies of S2 were sib-mated in 37 isolated plots. The progeny of best 11 S2 generation (F1 S2) was compared in field trials. Rot yield of F1 S2 was depressed in comparison to standard and varied from 75.2 to 91.8%, whereas the sugar content was somewhat lower or close to standard mean

Role of intermolecular interactions in assemblies of nanocontainers composed of carbon nanotubes and magnetic nanoparticles: A molecular dynamics study

10.1021/jp410736sJournal of Physical Chemistry C11821353-136

Monte Carlo Study of the Properties of a Carbon Nanotube Functionalized by Magnetic Nanoparticles

We present a computer simulation study of the behavior of a carbon nanotube in which both ends are connected to magnetic nanoparticles by a short alkane chain. Such a composite object reveals very interesting features depending on the type of magnetic nanoparticle (ferromagnetic or superparamagnetic). In the case of ferromagnetic nanoparticles, we observed that depending on the strength of the external magnetic field the nanotube mouths can be plugged or opened. It implies that the access to the nanotube interior can be easily controlled by switching on or off the external magnetic field. Such nanodevices might be very promising candidates for drug-delivery systems or storage materials with controllable release of encapsulated molecules. This paper discusses the conditions under which the desirable properties can be attained

Monte Carlo Study of the Properties of a Carbon Nanotube Functionalized by Magnetic Nanoparticles

We present a computer simulation study of the behavior of a carbon nanotube in which both ends are connected to magnetic nanoparticles by a short alkane chain. Such a composite object reveals very interesting features depending on the type of magnetic nanoparticle (ferromagnetic or superparamagnetic). In the case of ferromagnetic nanoparticles, we observed that depending on the strength of the external magnetic field the nanotube mouths can be plugged or opened. It implies that the access to the nanotube interior can be easily controlled by switching on or off the external magnetic field. Such nanodevices might be very promising candidates for drug-delivery systems or storage materials with controllable release of encapsulated molecules. This paper discusses the conditions under which the desirable properties can be attained

Molecular dynamics study of cisplatin release from carbon nanotubes capped by magnetic nanoparticles

10.1021/jp405593uJournal of Physical Chemistry C1173317327-1733