Azimuthal anisotropy at RHIC: the first and fourth harmonics

We report the first observations of the first harmonic (directed flow, v_1), and the fourth harmonic (v_4), in the azimuthal distribution of particles with respect to the reaction plane in Au+Au collisions at the Relativistic Heavy Ion Collider (RHIC). Both measurements were done taking advantage of the large elliptic flow (v_2) generated at RHIC. From the correlation of v_2 with v_1 it is determined that v_2 is positive, or {\it in-plane}. The integrated v_4 is about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8) harmonics upper limits on the magnitudes are reported.Comment: 6 pages with 3 figures, as accepted for Phys. Rev. Letters The data tables are at http://www.star.bnl.gov/central/publications/pubDetail.php?id=3

Human Health Risk Assessment For Arsenic: A Critical Review

Millions of people are exposed to arsenic resulting in a range of health implications.This paper provides an up-to-date review of the different sources of arsenic (water, soil and food), indicators of human exposure (biomarker assessment of hair, nail, urine and blood), epidemiological and toxicological studies on carcinogenic and non-carcinogenic health outcomes, and risk assessment approaches. The review demonstrates a need for more work evaluating the risks of different arsenic species such as; arsenate, arsenite monomethylarsonic acid, monomethylarsonous acid, dimethylarsinic acid and dimethylarsinous acid as well as a need to better integrate the different exposure sources in risk assessments

Accelerating change: flood hazard-disaster databases in the Indian Himalayan region

Executive Summary: The Problem: Increasing Disaster Risk in Mountain Regions and a Gap in Historical Disaster Knowledge. Disaster statistics for mountain regions reveal a concerning trend of increasing event occurrence, injuries and fatalities, and socio-economic impacts. This reflects increases in population, infrastructure exposure and vulnerability, as well as increasing hazard frequency and magnitude. Amplifying future concerns are complex/contested climate change trajectories and their impact on hazard processes. In response, a much better evaluation of future risk is required, and this needs an improved understanding of historical disaster impacts and losses. Closing this gap will support improved disaster risk reduction, climate change adaptation and sustainable infrastructure planning and development goals, underpinning improved wellbeing and livelihood. The Time for Action, Surging to 2030: Accelerating Implementation of Flood Hazard-Disaster Databases in the Indian Himalayan Region The UNDRR 'Sendai Framework for Disaster Risk Reduction 2015-2030' (SFDRR) is driving global efforts to stem disaster losses and build resilience via a targeted approach. Since 2015 the SFDRR has continued to mature from an elaborate framework statement to that of a growing implementation effort, now with a 'Surge to 2030'. India as a signatory of the SFDRR, and member of the pan-national Asia-Pacific Ministerial Conference on Disaster Risk Reduction, has embraced calls to develop and implement methodologies for the compilation of improved disaster loss data to reduce future disaster impacts, particularly in high-risk flood locations such as the Indian Himalaya. Whilst India can utilise multiple existing global, national, and state disaster databases, it is accepted that these are not necessarily comprehensive, interoperable, accessible, or sufficiently localised. Accordingly, there is a need for new partnership efforts to deliver disaggregated and sub-national flood disaster data. Key Policy-Practice Options: (1) Enhancing Knowledge in the Kullu District & Himachal Pradesh: Using 'HiFlo-DAT' to revise disaster management plans and the HVRA database; engage local communities in two-way knowledge sharing; and review planning requirements for infrastructure projects (State and National) (2) Indian National Disaster Management Policy & Practice Development: Undertake policy review on flood database curation, application and governance; consider the integration and hierarchy of Indian disaster databases; and undertake dedicated review of LLOF and GLOF floods (3) Upscaling of Historical Flood Databases across the IHR: Via partnerships and an array of data sources

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers

The spleen tyrosine kinase (SYK) regulates immune cell activation in response to engagement of a variety of receptors, making it an intriguing target for the treatment of inflammatory and autoimmune disorders as well as certain B-cell malignancies. We have previously reported on the discovery and preclinical characterization of PRT062607, a potent and highly selective inhibitor of SYK that exhibits robust anti-inflammatory activity in a variety of animal models. Here we present data from our first human studies aimed at characterizing the pharmacokinetics (PK), pharmacodynamics (PD), and safety of PRT062607 in healthy volunteers following single and multiple oral administrations. PRT062607 demonstrated a favorable PK profile and the ability to completely inhibit SYK activity in multiple whole-blood assays. The PD half-life in the more sensitive assays was approximately 24 hours and returned to predose levels by 72 hours. Selectivity for SYK was observed at all dose levels tested. Analysis of the PK/PD relationship indicated an IC50 of 324 nM for inhibition of B-cell antigen receptor-mediated B-cell activation and 205 nM for inhibition of FcεRI-mediated basophil degranulation. PRT062607 was safe and well tolerated across the entire range of doses. Clinical PK/PD was related to in vivo anti-inflammatory activity of PRT062607 in the rat collagen-induced arthritis model, which predicts that therapeutic concentrations may be safely achieved in humans for the treatment of autoimmune disease. PRT062607 has a desirable PK profile and is capable of safely, potently, and selectively suppressing SYK kinase function in humans following once-daily oral dosing

HiFlo-DAT: Indian Himalayan Flood Database, for Disaster Risk Reduction in the Kullu District

‘HiFlo-DAT’ is an ongoing bi-lateral research project (UK and India, UGC-UKIERI funded, 2018-2020), focussing on historical floods in the Kullu District, Himachal Pradesh, Indian Himalaya. The project team, comprising academic and state/district disaster management authorities, are together developing a new historical flood hazard database as a foundation for improved disaster risk management functions in the region. This is necessary as current management relies on incomplete knowledge of past flood event occurrence, bringing elevated exposure/ risk to development. The HiFlo-DAT database provides a step-change, drawing on extensive mining of archive materials held in private and public collections in India, UK and USA. These materials include newspapers, government reports/ registers, diaries, books, academic articles etc. Most extensive are English language Indian region newspapers, of which we have amassed overlapping holdings over 184 years (1835 to present), totalling c. 150,000 pages. Our acquisition includes coverage of annual periods where publications are digitally searchable (e.g. The Tribune, The Times of India, The Indian Express). In contrast, where archives remain in an analogue microfilm format (e.g. The Civil and Military Gazette, The Friend of India) we restricted data searches to monsoon season months (i.e. July to September) given this is the typical window for floods in the Western Himalaya. The HiFlo-DAT database architecture takes account of best practice, having systematically reviewed global (most commonly European) flood database research in the last c. 30 years, in regard to database structure, data entry/verification protocols, analytical foci and societal impact. HiFlo-DAT has 103 possible entry categories for each event record, which are aggregated into 11 principal groups (i.e. database management, citation information, timing/ duration, location, causation and hydro-meteorological magnitude, channel/ catchment geomorphological impacts, damage/ destruction/ costs, human casualties, pre-event actions, event response, post-event actions). The bi-lateral review of source materials and population of the database are governed by an agreed set of protocols. Initial analyses are focussing on: (1) event spatial/ temporal/ impact signatures; (2) the relationship between flood occurrence and rainfall conditions. The latter makes use of a unique long-term daily rainfall series for Naggar Farm, being compiled from British government records (1891-1950) and current IARI data (1962 to present). HiFlo-DAT is designed with capacity for future updating, and will be open access via the BathSPAdata repository and HPSDMA website

Room Temperature Electrochemical Synthesis of Hg-1212 Superconducting Thin Films

In the present investigation, the novel two-step electrochemical process of room temperature synthesis of Hg-1212 superconducting films has been developed and reported first time. Electrochemical parameters were optimized by studying cyclic voltammetry (CV), linear sweep voltammetry (LSV) and chronoamperometry (CA) for the deposition of Hg-Ba-Ca-Cu alloy at room temperature. Current time transient showed progressive growth with hemispheriodal granules, which were then revealed by scanning electron microscopy (SEM). Stoichiometric electrocrystallization to get Hg1Ba2Ca1Cu2O6+x (Hg-1212) was completed by electrochemically intercalating oxygen species into Hg-Ba-Ca-Cu alloy at room temperature. The oxygen content in the samples was varied by varying the electrochemical oxidation period and the changes in the crystal structure, microstructure, and superconducting transition temperature (Tc) and critical current density (Jc) were recorded. The films oxidized for 28 min showed Tc = 104.7 K with Jc = 1.437 x 103 A/cm2. The dependence of superconducting parameters on oxygen content is correlated with structure property relations and reported in this paper.Comment: 39 pages, 17 figures. Submitted to Physica

Tracking of an electron beam through the solar corona with LOFAR

The Sun's activity leads to bursts of radio emission, among other phenomena. An example is type-III radio bursts. They occur frequently and appear as short-lived structures rapidly drifting from high to low frequencies in dynamic radio spectra. They are usually interpreted as signatures of beams of energetic electrons propagating along coronal magnetic field lines. Here we present novel interferometric LOFAR (LOw Frequency ARray) observations of three solar type-III radio bursts and their reverse bursts with high spectral, spatial, and temporal resolution. They are consistent with a propagation of the radio sources along the coronal magnetic field lines with nonuniform speed. Hence, the type-III radio bursts cannot be generated by a monoenergetic electron beam, but by an ensemble of energetic electrons with a spread distribution in velocity and energy. Additionally, the density profile along the propagation path is derived in the corona. It agrees well with three-fold coronal density model by (1961, ApJ, 133, 983).</p

LOFAR: The LOw-Frequency ARray

LOFAR, the LOw-Frequency ARray, is a new-generation radio interferometer constructed in the north of the Netherlands and across europe. Utilizing a novel phased-array design, LOFAR covers the largely unexplored low-frequency range from 10-240 MHz and pro

Mapping child growth failure across low- and middle-income countries

Childhood malnutrition is associated with high morbidity and mortality globally1. Undernourished children are more likely to experience cognitive, physical, and metabolic developmental impairments that can lead to later cardiovascular disease, reduced intellectual ability and school attainment, and reduced economic productivity in adulthood2. Child growth failure (CGF), expressed as stunting, wasting, and underweight in children under five years of age (0�59 months), is a specific subset of undernutrition characterized by insufficient height or weight against age-specific growth reference standards3�5. The prevalence of stunting, wasting, or underweight in children under five is the proportion of children with a height-for-age, weight-for-height, or weight-for-age z-score, respectively, that is more than two standard deviations below the World Health Organization�s median growth reference standards for a healthy population6. Subnational estimates of CGF report substantial heterogeneity within countries, but are available primarily at the first administrative level (for example, states or provinces)7; the uneven geographical distribution of CGF has motivated further calls for assessments that can match the local scale of many public health programmes8. Building from our previous work mapping CGF in Africa9, here we provide the first, to our knowledge, mapped high-spatial-resolution estimates of CGF indicators from 2000 to 2017 across 105 low- and middle-income countries (LMICs), where 99 of affected children live1, aggregated to policy-relevant first and second (for example, districts or counties) administrative-level units and national levels. Despite remarkable declines over the study period, many LMICs remain far from the ambitious World Health Organization Global Nutrition Targets to reduce stunting by 40 and wasting to less than 5 by 2025. Large disparities in prevalence and progress exist across and within countries; our maps identify high-prevalence areas even within nations otherwise succeeding in reducing overall CGF prevalence. By highlighting where the highest-need populations reside, these geospatial estimates can support policy-makers in planning interventions that are adapted locally and in efficiently directing resources towards reducing CGF and its health implications. © 2020, The Author(s)