Measures of a sustainable commute as a predictor of happiness

The ways in which we travel—by what mode, for how long, and for what purpose—can affect our sense of happiness and well-being. This paper assesses the relationships between measures of the sustainability of transportation systems in U.S. metropolitan areas and subjective well-being. Associations between self-reported happiness levels from the Gallup Healthways Well-being Index and commute data were examined for 187 core-based statistical areas (CBSA). Wealsosupplementthisquantitativeanalysisthroughbriefcasestudiesofhigh-andlow-performing happiness cities. Our quantitative results indicate that regions with higher commute mode shares by non-automobile modes generally had higher well-being scores, even when controlling for important economic predictors of happiness. We also find that pro-sustainable transportation policies can have implications for population-wide happiness and well-being. Our case studies indicate that both high and low scoring happiness cities demonstrate a dedicated commitment to improving sustainable transportation infrastructure. Our study suggests that cities that provide incentives for residents to use more sustainable commute modes may offer greater opportunity for happiness than those that do not

Moisture buffering and mould growth characteristics of naturally ventilated lime plastered houses

Lime plaster is a sustainable building material that can be an effective passive cooling strategy. The moisture buffering quality of lime causes adsorption and desorption of moisture which moderates the indoor relative humidity. Its vapour permeability is also influential in moisture transfer across the building envelope. Lime plaster also has a self-healing quality which prevents the formation of inner cracks. Moreover, its strength increases with time leading to a longer life span. In old structures, an important function is the breathability of ceilings and walls. Hence, it is often used in conservation projects where it improves the appearance and durability of old buildings. Often organic additives employed to impart certain qualities to the lime mortar/plaster led to mould growth. Mould growth degrades indoor air quality, and the occupant health is compromised. To avoid mould related problems, it is necessary to understand the behaviour of lime plaster with respect to the indoor relative humidity and surface moisture content. This paper focuses on the hygrothermal performance of lime plaster in naturally ventilated residential spaces. Surveys were carried out in 45 traditional buildings in Ahmedabad in India with measurements of ambient variables, such as temperature, relative humidity, wall moisture content, etc. The mould growth patterns of these spaces are related to the measured variables and wall characteristics. Hygrothermal simulations of some spaces were also carried out to observe the moisture buffering of lime plaster. Experimental observations were then compared to simulation results to see if the predictions of the hygrothermal models were realistic

Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats

Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption. The role of 5HT in bone therefore remains poorly understood. To address this issue, we used selective breeding to create rat sublines with constitutively high (high-5HT) and low (low-5HT) platelet 5HT level (PSL) and platelet 5HT uptake (PSU). High-5HT rats had decreased bone volume due to increased bone turnover characterized by increased bone formation and mineral apposition rate, increased osteoclast number and serum C-telopeptide level. Daily oral administration of the TPH1 inhibitor (LX1032) for 6 weeks reduced PSL and increased the trabecular bone volume and trabecular number of the spine and femur in high-5HT rats. High-5HT animals also developed a type 2 diabetes (T2D) phenotype with increased: plasma insulin, glucose, hemoglobin A1c, body weight, visceral fat, β-cell pancreatic islets size, serum cholesterol, and decreased muscle strength. Serum calcium accretion mediated by parathyroid hormone slightly increased, whereas treatment with 1,25(OH)2D3 decreased PSL. Insulin reduction was paralleled by a drop in PSL in high-5HT rats. In vitro, insulin and 5HT synergistically up-regulated osteoblast differentiation isolated from high-5HT rats, whereas TPH1 inhibition decreased the number of bone marrow-derived osteoclasts. These results suggest that constitutively elevated PSL is associated with bone loss and T2D via a homeostatic interplay between the peripheral 5HT, bone and insulin

Educational Knowledge Brokerage and Mobilization: The Marshall Memo Case

The importance of intermediation between communities primarily engaged in research production and those primarily engaged in practice is increasingly acknowledged, yet our understanding of the nature and influence of this work in education remains limited. Accordingly, this study utilizes case study methodology and aspires to understand the activities and signature product (the Marshall Memo) of a particularly influential mediator of current educational research, news, and ideas: Mr. Kim Marshall. The article also examines the memo’s meaning to subscribing educators. Data analyses suggest subscribers greatly appreciate several aspects of the memo, which was found to draw from a wide range of source material that varies in terms of its research centredness and its practical implications

CoCast - SLR

We are currently living in a world surrounded by technology, making us very dependent on the little nitty gritty way of accomplishing tasks efficiently. Being mindful of the of the changes that are occurring upon us, we are compelled to helping where possible. Personally, Sheridan College pilots their very own campus radio station – Sheridan Life Radio (SLR) a member of the National Campus and Community Radio Association, whose main aim is to bring a little bit of everything to the table covering special occasions such as Canadian upcoming holidays, Valentine’s Day, Mother’s Day to motivational and inspirational podcasts. SLR primarily doesn’t only produce content for the college but for podcasting platforms such as Spotify, Google Podcasts and Apple Podcast. Hence, keeping in mind of the wide variety of topics that the SLR tackles, the most troublesome one happens to be the management of podcasts. Where the mode of operation for them currently is to have individuals chase producing – the act of finding guests, stories and angles and collaborative podcasting process. This process can be nerve-wreaking and frustrating. To help SLR overcome this problem a proposed solution is to have procuring audio clips to one stop location for the clip gathering cutting the stress and effect of people personally being out and about in the field. Since the proposed solution aims to make the way of operation smarted and less stressful for the SLR team it is called Co-Cast

Prescription Drug Abuse among 12 to 17 Year Adolescents in the United States

This study examines issues related to prescription drug abuse among 12 – 17 year olds in the United States; namely, the physiological effects of prescription medications, current treatments, and prevention methods. The following research questions are addressed: 1) What factors influence and promote the growing prevalence of prescription drug abuse among 12 to 17 year olds in the United States? 2) What efforts are being made to address/prevent the prescription drug abuse among 12 to 17 year olds in the United States? 3) What is the relationship between mental disability and prescription drug abuse among 12 to 17 year olds in the United States? 4) To what extent do gender and ethnicity have an effect on the prescription drug abuse among 12 to 17 year olds in the United States? and 5) To what extent does a history of substance abuse lead to current prescription drug abuse among 12 to 17 year olds in the United States? Conclusive answers to the above questions are difficult to establish because further research still needs to be conducted on the various factors surrounding prescription drug abuse among adolescents

Materials in particulate form for tissue engineering. 2 Applications in bone

Materials in particulate form have been the subjects of intensive research in view of their use as drug delivery systems. While within this application there are still issues to be addressed, these systems are now being regarded as having a great potential for tissue engineering applications. Bone repair is a very demanding task, due to the specific characteristics of skeletal tissues, and the design of scaffolds for bone tissue engineering presents several difficulties. Materials in particulate form are now seen as a means of achieving higher control over parameters such as porosity, pore size, surface area and the mechanical properties of the scaffold. These materials also have the potential to incorporate biologically active molecules for release and to serve as carriers for cells. It is believed that the combination of these features would create a more efficient approach towards regeneration. This review focuses on the application ofmaterials in particulate formfor bone tissue engineering. A brief overview of bone biology and the healing process is also provided in order to place the application in its broader context. An original compilation of molecules with a documented role in bone tissue biology is listed, as they have the potential to be used in bone tissue engineering strategies. To sum up this review, examples of works addressing the above aspects are presented

A novel link between the proteasome pathway and the signal transduction pathway of the Bone Morphogenetic Proteins (BMPs)

BACKGROUND: The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding transcriptional modulators and shown to recruit the master transcriptional co-activator CBP/p300 for transcriptional activation. SNIP1 is a recently discovered novel repressor of CBP/p300. Currently, the detailed molecular mechanisms that allow R-Smads and Co-Smad to co-operatively modulate transcription events are not fully understood. RESULTS: Here we report a novel physical and functional link between Smad1 and the 26S proteasome that contributes to Smad1- and Smad4-mediated transcriptional regulation. Smad1 forms a complex with a proteasome β subunit HsN3 and the ornithine decarboxylase antizyme (Az). The interaction is enhanced upon BMP type I receptor activation and occur prior to the incorporation of HsN3 into the mature 20S proteasome. Furthermore, BMPs trigger the translocation of Smad1, HsN3 and Az into the nucleus, where the novel CBP/p300 repressor protein SNIP1 is further recruited to Smad1/HsN3/Az complex and degraded in a Smad1-, Smad4- and Az-dependent fashion. The degradation of the CBP/p300 repressor SNIP1 is likely an essential step for Smad1-, Smad4-mediated transcriptional activation, since increased SNIP1 expression inhibits BMP-induced gene responses. CONCLUSIONS: Our studies thus add two additional important functional partners of Smad1 into the signaling web of BMPs and also suggest a novel mechanism for Smad1 and Smad4 to co-modulate transcription via regulating proteasomal degradation of CBP/p300 repressor SNIP1

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

Impaired ribosome function is the underlying etiology in a group of bone marrow failure syndromes called ribosomopathies. However, how ribosomes are regulated remains poorly understood, as are approaches to restore hematopoietic stem cell (HSC) function loss because of defective ribosome biogenesis. Here we reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation. Hectd1-deficient HSCs exhibit a striking defect in transplantation ability and ex vivo maintenance concomitant with reduced protein synthesis and growth rate under stress conditions. Mechanistically, HectD1 ubiquitinates and degrades ZNF622, an assembly factor for the ribosomal 60S subunit. Hectd1 loss leads to accumulation of ZNF622 and the anti-association factor eIF6 on 60S, resulting in 60S/40S joining defects. Importantly, Znf622 depletion in Hectd1-deficient HSCs restored ribosomal subunit joining, protein synthesis, and HSC reconstitution capacity. These findings highlight the importance of ubiquitin-coordinated ribosome assembly in HSC regeneration

Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors

Ribosomal RNAs (rRNAs) are the most abundant cellular RNAs, and their synthesis from rDNA repeats by RNA polymerase I accounts for the bulk of all transcription. Despite substantial variation in rRNA transcription rates across cell types, little is known about cell-type-specific factors that bind rDNA and regulate rRNA transcription to meet tissue-specific needs. Using hematopoiesis as a model system, we mapped about 2,200 ChIP-seq datasets for 250 transcription factors (TFs) and chromatin proteins to human and mouse rDNA and identified robust binding of multiple TF families to canonical TF motifs on rDNA. Using a 47S-FISH-Flow assay developed for nascent rRNA quantification, we demonstrated that targeted degradation of C/EBP alpha (CEBPA), a critical hematopoietic TF with conserved rDNA binding, caused rapid reduction in rRNA transcription due to reduced RNA Pol I occupancy. Our work identifies numerous potential rRNA regulators and provides a template for dissection of TF roles in rRNA transcription