Craneoplastia: efectos de la reposición del cogajo óseo sobre la hemodinámica cerebral

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 18-01-2016Depto. de CirugíaFac. de MedicinaTRUEunpu

Sobre a centralidade urbana de Jardim-MS: notas a partir da escala de uma cidade pequena

Resumo: O presente ensaio visa lançar reflexões sobre centralidade urbana a partir de duas escalas conceituais, quais sejam: a escala do espaço intraurbano, da cidade, com suas porções espaciais que se articulam dialeticamente na relação parte-todo; e a escala interurbana, ou seja, do conjunto funcionalmente articulado de centros urbanos. Tal reflexão girará em torno da análise de uma cidade pequena, com seu sítio urbano localizado na porção territorial sul-mato-grossense da formação espacial brasileira, mais especificamente no Sudoeste do Mato Grosso do Sul, qual seja, Jardim-MS. Entendendo a centralidade urbana como uma construção social, no âmago do processo de produção do espaço, o escopo desse trabalho visa apreender como essa característica (a centralidade), apreensível na dimensão funcional do espaço, liga-se ao conjunto de formas materializadas pela sociedade no espaço. Palavras-chave: centralidade urbana; produção do espaço; cidade pequena; escala. &nbsp

Fronteiras na cidade: das margens na margem às margens no centro

  This essay aims to make some considerations about frontier. In addition to its geographical dimension, generally associated at the common sense level with the notion of boundary between two Nation-sStates, the frontier carries a social, symbolic/immaterial dimension that is projected in the geographical space, unfolding in numerous socio-spatial relations. Far from realizing the complexity/multiplicity of these innumerable relations that produce and occur in space, we propose a dialogical essay, using two socio-spatial situations/realities – the conurbation Ponta Porã/MS (BR) X Pedro Juan Caballero (PY) and the city of Dourados/MS. From these portions of space we bring some examples/situations where boundaries are sometimes material, others immaterial, some geographical symbolic, in order to contribute to the understanding of these socio-spatial relations and also to the understanding of the polysemy of this term/notion/concept – border.O presente ensaio visa a tecer algumas considerações sobre fronteira. Para além de sua dimensão geográfica, geralmente associada, no nível do senso comum, à noção de limite entre dois Estados-Nação, a fronteira carrega uma dimensão social, simbólica/imaterial que são projetadas no espaço geográfico, se desdobrando em inúmeras relações socioespaciais. Longe de darmos conta da complexidade/multiplicidade dessas inúmeras relações que produzem e se dão no espaço, propomos um ensaio dialógico, valendo-nos de duas situações/realidades socioespaciais – a conurbação Ponta Porã/MS (BR) X Pedro Juan Caballero (PY) e a cidade de Dourados/MS. A partir dessas porções do espaço trazemos alguns exemplos/situações onde são estabelecidas fronteiras às vezes materiais, outras imateriais, algumas geográficas outras simbólicas, de modo a contribuir para o entendimento dessas relações socioespaciais e também à compreensão da polissemia desse termo/noção/conceito – fronteira

NOTAS SOBRE O QUADRO URBANO DO ESTADO DE MATO GROSSO DO SUL

O presente trabalho visa a abordar o território sul-mato-grossense, focando no conjunto funcionalmente articulado de cidades que compõe sua estrutura urbana. Formado, em sua maior parte, por cidades pequenas e cidades locais, e algumas, quatro cidades, com maior grau de complexidade funcional e porte populacional, o território sul-mato-grossense denota o curso que o processo de urbanização tomou no estado. A análise dessa estrutura, no âmago do processo de formação territorial e da urbanização do Mato Grosso do Sul, revela-se de significativa importância para compreensão do quadro urbano atual – do papel regional que essas cidades de maior complexidade funcional (Campo Grande, Dourados, Três Lagoas e Corumbá) exercem sobre suas hinterlândias. Nesse sentido, o ensaio, além de abordar o papel de centralidade atual dessas cidades na rede, volta-se a resgatar, resumidamente, os fatores que determinaram e condicionaram a dinâmica urbana e regional desses centros urbano

Das horizontalidades às verticalidades: Reflexões sobre a rede urbana no estado de Mato Grosso do Sul

O presente ensaio visa refletir sobre a rede urbana no estado de Mato Grosso do Sul, considerando o par horizontalidade e verticalidade, cunhado por Santos (1994). Para o embasamento do diálogo, além do apoio no último estudo da publicação Regiões de Influência das Cidades – REGIC (IBGE, 2018), que apresenta dados sobre a redes urbana, abordaremos também, inspirados no caminho metodológico de Catelan (2012), os dados de importações e exportações dos centros urbanos do estado, a partir da consulta à plataforma COMEX STAT do Ministério do Desenvolvimento, Indústria, Comércio e Serviços, para avaliar como se inserem na condição de consumo, distribuição e produção. Alguns produtos cartográficos (rede urbana, importações e exportações do Mato Grosso do Sul) foram sistematizados utilizando o software ArcGis 10.8.2

New highly charged iron(III) metal-organic cube stabilized by a bulky amine.

In this work, we report a new octanuclear cluster based on FeIII and the ligand 1H-imidazole-4,5-dicarboxylic acid, [Et3NH]12[Fe8(IDC)12]·10DMF·13H2O (1), with a metal core containing eight FeIII connected by only one type of organic ligand. A peak at 573 m/z in the mass spectra of the compound suggests the adduct species {[Fe8(IDC)12]+8H}4-. By X-ray photoelectron spectroscopy, the oxidation state of the iron cation was confirmed to be 3+, also identifying the presence of a quaternary nitrogen species, which act as a countercation of the anionic metal core [Fe8(IDC)12]12-. Mössbauer spectra recorded at different temperatures show an isomer shift and quadrupole splitting parameters that confirm the existence of only FeIII-HS in the structure of 1. X-ray analysis reveals that compound 1 crystallizes in the orthorhombic system space group Ibam, confirming a molecular cluster structure with an almost regular cube as geometry, with the FeIII atoms located at the corners of the cube and connected by μ-1κ2 N,O:2κ2 N',O‴-IDC3- bridges. Additionally, the magnetic measurements reveal a weak antiferromagnetic coupling in the Fe8 III coordination cluster (J = -3.8 cm-1). To the best of our knowledge, 1 is the first member of the family of cubes assembled with 1H-imidazole-4,5-dicarboxylic acid and FeIII cation, exhibiting high pH stability over a broad pH range, making it an ideal candidate for the design of supramolecular structures and metal-organic frameworks

Validation of <i>N</i>-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of <i>Trypanosoma cruzi</i>

BACKGROUND:Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected tropical disease has become a global health concern. The two clinically available drugs for the chemotherapy of Chagas disease have rather high toxicity and limited efficacy in the chronic phase of the disease, and may induce parasite resistance. The development of new anti-T. cruzi agents is therefore imperative. The enzyme N-myristoyltransferase (NMT) has recently been biochemically characterized, shown to be essential in Leishmania major, Trypanosoma brucei, and T. cruzi¸ and proposed as promising chemotherapeutic target in these trypanosomatids. METHODOLOGY/PRINCIPAL FINDINGS:Here, using high-content imaging we assayed eight known trypanosomatid NMT inhibitors, against mammal-dwelling intracellular amastigote and trypomastigote stages and demonstrated that three of them (compounds 1, 5, and 8) have potent anti-proliferative effect at submicromolar concentrations against T. cruzi, with very low toxicity against human epithelial cells. Moreover, metabolic labeling using myristic acid, azide showed a considerable decrease in the myristoylation of proteins in parasites treated with NMT inhibitors, providing evidence of the on-target activity of the inhibitors. CONCLUSIONS/SIGNIFICANCE:Taken together, our data point out to the potential use of NMT inhibitors as anti-T. cruzi chemotherapy

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Hydroethanolic extract of lampaya medicinalis phil. (verbenaceae) decreases proinflammatory marker expression in palmitic acid-exposed macrophages

Background: Obesity is a major health problem associated with increased comorbiditics, which are partially triggered by inflammation. Proinflaminatory macrophage infiltration in adipose tissue of individuals with obesity increases chronic inflammation. Obesity is associated with elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which promotes inflammation in vivo and in vitro. Infusions of Lampaya medicinalis Phil. (Verbenaceae) are used in the folk medicine of Northern Chile to counteract inflammation of rheumatic diseases. Hydroethanolic extract of lampaya (HEL) contains spectrophotometrically defined compounds that may contribute to the observed effect on inflammation. Methods: We evaluated the phytochemical composition of HEL by high-performance liquid chromatography coupled to diode array detection (HPLC-DAD) and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). We assessed whether the exposure to HEL affects PA-induced expression of proinflammatory factors in THP-1 macrophages. Results: HPLC-DAD and LC-ESI-MS/MS analyses showed the presence of considerable amounts of flavonoids in HEL. The PA-induced phosphorylation of the inflammatory pathway mediators IKK and NF-kappa B, as well as the elevated expression and secretion of proinflammatory cytokines (IL-6, TNF-alpha), were reduced in cells pre-exposed to HEL. Conclusion: These findings give new insights about the effect of HEL reducing IKK/NF-kappa B proinflammatory pathway, likely explained by the number of flavonoids contained in the extract. More studies would be needed to define the possible role of Lampaya as a preventive approach in subjects with obesity whose circulating PA might contribute to chronic inflammation.Universidad de O'Higgins research fund Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1150651 Network for Extreme Environments Research (NEXER) ANT1756 Universidad de Antofagasta, Chil