18,125 research outputs found
You never surf alone. Ubiquitous tracking of users' browsing habits
In the early age of the internet users enjoyed a large level of anonymity. At
the time web pages were just hypertext documents; almost no personalisation of
the user experience was o ered. The Web today has evolved as a world wide
distributed system following specific architectural paradigms. On the web now,
an enormous quantity of user generated data is shared and consumed by a network
of applications and services, reasoning upon users expressed preferences and
their social and physical connections. Advertising networks follow users'
browsing habits while they surf the web, continuously collecting their traces
and surfing patterns. We analyse how users tracking happens on the web by
measuring their online footprint and estimating how quickly advertising
networks are able to pro le users by their browsing habits
Quantifying the Inefficiency of the US Social Security System
We quantify the inefficiency of the retirement component of the US social security system within a model where agents receive idiosyncratic labor-productivity shocks that are privately observedsocial security, efficient allocations, idiosyncratic shocks
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats
Indexación: Web of Science; Scopus.Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Adult male Sprague-Dawley rats were randomly divided into control and stressed groups, and were daily restrained in their motion (2.5 h/day) during 14 days. We found that chronic stress promotes an increase in c-Fos mRNA levels in both hippocampal areas, although it was observed a reduction in the immunoreactivity at pyramidal cell layer. Furthermore, Arc mRNAs levels were increased in both dorsal and VH, accompanied by an increase in Arc immunoreactivity in dendritic hippocampal layers. Furthermore, stress triggered a reduction in PSD-95 and NR1 protein levels in whole extract of dorsal and VH. Moreover, a reduction in NR2A/NR2B ratio was observed only in dorsal pole. In synaptosomal fractions, we detected a rise in NR1 in dorsal hippocampus (DH). By indirect immunofluorescence we found that NR1 subunits rise, especially in neuropil areas of dorsal, but not VH. In relation to AMPA receptor (AMPAR) subunits, chronic stress did not trigger any change, either in dorsal or ventral hippocampal areas. These data suggest that DH is more sensitive than VH to chronic stress exposure, mainly altering the expression of NMDA receptor (NMDAR) subunits, and probably favors changes in the configuration of this receptor that may influence the function of this area.https://www.frontiersin.org/articles/10.3389/fnmol.2017.00244/ful
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents.
The Trier Social Stress Test (TSST) is a well validated and widely used social stressor that has been shown to induce a 2-4 fold increase in cortisol, the biological output produced by the Hypothalamic-Pituitary-Adrenal (HPA) axis in humans. While studies have explored how modifications to the TSST influence stress responsivity, few studies have created a modified TSST appropriate for vulnerable youth that elicits a significant cortisol stress response. Thus, the current study sought to modify or adjust the TSST in a culturally sensitive way for a vulnerable sample of 14 year-old adolescents. The present study took place within the context of a longitudinal birth cohort study of Mexican American families in California called the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS). The CHAMACOS sample was optimal to test the effectiveness of a modified culturally appropriate TSST, as it is comprised of Mexican American youth, who are often excluded from research. These youths also have experienced significant early life adversity. Example modifications included timed prompts, alternative math tasks, use of same-ethnicity peers as confederates, debriefing immediately after the conclusion of the TSST, and using an unknown youth examiner to administer the debrief. Saliva samples were collected at baseline (after a resting phase), and then again at 15, 30, and 45 min post-TSST onset to assess cortisol concentration. A pilot study of 50 participants (50% female) have been analyzed for cortisol reaction to the TSST. Results confirmed that this modified version of the TSST was successful at eliciting a significant cortisol reaction, with a wide range of variability likely due to individual differences. Goals for modifications and ethnicity considerations are discussed. This study provides the foundation for future research to utilize a modified TSST with vulnerable youth
Dexmedetomidine-methadone-ketamine versus dexmedetomidine-methadone-alfaxalone for cats undergoing ovariectomy
Quantitative Stability and Optimality Conditions in Convex Semi-Infinite and Infinite Programming
This paper concerns parameterized convex infinite (or semi-infinite)
inequality systems whose decision variables run over general
infinite-dimensional Banach (resp. finite-dimensional) spaces and that are
indexed by an arbitrary fixed set T . Parameter perturbations on the right-hand
side of the inequalities are measurable and bounded, and thus the natural
parameter space is . Based on advanced variational analysis, we
derive a precise formula for computing the exact Lipschitzian bound of the
feasible solution map, which involves only the system data, and then show that
this exact bound agrees with the coderivative norm of the aforementioned
mapping. On one hand, in this way we extend to the convex setting the results
of [4] developed in the linear framework under the boundedness assumption on
the system coefficients. On the other hand, in the case when the decision space
is reflexive, we succeed to remove this boundedness assumption in the general
convex case, establishing therefore results new even for linear infinite and
semi-infinite systems. The last part of the paper provides verifiable necessary
optimality conditions for infinite and semi-infinite programs with convex
inequality constraints and general nonsmooth and nonconvex objectives. In this
way we extend the corresponding results of [5] obtained for programs with
linear infinite inequality constraints
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