A case of successful treatment of pylephlebitis in a patient with acute appendicitis

Pylephlebitis is a rare and potentially lethal complication of acute appendicitis. It leads to the development of liver abscesses and sepsis. Usually, this  complication is the result of late diagnosis. Only rare cases of successful treatment of pylephlebitis in the context of acute appendicitis are published in special literature.The aim of the demonstration is to analyze of the diagnosis and medical tactic mistakes as a case of pylephlebitis in a patient with acute appendicitis; show the possibilities of modern methods of diagnosis and treatment, which made it possible to achieve a success.The case of successful treatment patient with pylephlebitis was shown in the article. Late diagnosis of acute appendicitis was associated with the patient’s refusal and with some diagnostic and tactic mistakes that were analyzed. The case presented by jaundice, liver failure and fever. Thrombosis of portal vein diagnosed by U/S, CT scan with intravenous contrast on day 11 of the illness. Appendectomy was performed. Intensive care with extracorporeal therapy, antibacterial and anticoagulant therapy were also provided. Septic thrombosis  of portal vein was complicated by an abscess of the right lobe of the liver and sepsis. The case of successful treatment of patient with septic thrombosis of portal vein and superior mesenteric vein complicated by liver abscess and sepsis is considered in the article. Intensive therapy, extracorporeal detoxification and abdominal abscess drainage under the U/S control have resulted in a fully  repatency of portal vein that was confirmed by CT scan data

Human platelet concentrates treated with microbicidal 405 nm light retain hemostasis activity

Chemical and UV light-based pathogen reduction technologies are currently in use for human platelet concentrates (PCs) to enhance safety from transfusion-transmitted infections. Relative to UV light, 405 nm violet-blue light in the visible spectrum is known to be less harmful. Hence, in this report for the first time, we have assessed the global hemostasis activity of PCs stored in plasma and the activities of six plasma coagulation factors (CFs) as a measure of in vitro hemostatic activity following exposure to the microbicidal 405 nm light. Apheresis PC samples collected from each screened human donor (n = 22) were used for testing of PCs and platelet poor plasma (PPP). Both PCs and PPPs were treated for 5 h with 405 nm light to achieve a previously established microbicidal light dose of 270 J/cm2. Activated partial thromboplastin time and prothrombin time-based potency assays using a coagulation analyzer and hemostatic capacity via Thromboelastography were analyzed. Thromboelastography analysis of the light-treated PCs and plasma present in the PCs showed little difference between the treated and untreated samples. Further, plasma present in the PCs during the light treatment demonstrated a better stability in potency assays for several coagulation factors compared to the plasma alone prepared from PCs first and subjected to the light treatment separately. Overall, PCs stored in plasma treated with 405 nm violet-blue light retain activity for hemostasis

The seventh blind test of crystal structure prediction: structure ranking methods

\ua9 2024 International Union of Crystallography. All rights reserved. A seventh blind test of crystal structure prediction has been organized by the Cambridge Crystallographic Data Centre. The results are presented in two parts, with this second part focusing on methods for ranking crystal structures in order of stability. The exercise involved standardized sets of structures seeded from a range of structure generation methods. Participants from 22 groups applied several periodic DFT-D methods, machine learned potentials, force fields derived from empirical data or quantum chemical calculations, and various combinations of the above. In addition, one non-energy-based scoring function was used. Results showed that periodic DFT-D methods overall agreed with experimental data within expected error margins, while one machine learned model, applying system-specific AIMnet potentials, agreed with experiment in many cases demonstrating promise as an efficient alternative to DFT-based methods. For target XXXII, a consensus was reached across periodic DFT methods, with consistently high predicted energies of experimental forms relative to the global minimum (above 4 kJ mol- 1 at both low and ambient temperatures) suggesting a more stable polymorph is likely not yet observed. The calculation of free energies at ambient temperatures offered improvement of predictions only in some cases (for targets XXVII and XXXI). Several avenues for future research have been suggested, highlighting the need for greater efficiency considering the vast amounts of resources utilized in many cases

The seventh blind test of crystal structure prediction: structure ranking methods.

A seventh blind test of crystal structure prediction has been organized by the Cambridge Crystallographic Data Centre. The results are presented in two parts, with this second part focusing on methods for ranking crystal structures in order of stability. The exercise involved standardized sets of structures seeded from a range of structure generation methods. Participants from 22 groups applied several periodic DFT-D methods, machine learned potentials, force fields derived from empirical data or quantum chemical calculations, and various combinations of the above. In addition, one non-energy-based scoring function was used. Results showed that periodic DFT-D methods overall agreed with experimental data within expected error margins, while one machine learned model, applying system-specific AIMnet potentials, agreed with experiment in many cases demonstrating promise as an efficient alternative to DFT-based methods. For target XXXII, a consensus was reached across periodic DFT methods, with consistently high predicted energies of experimental forms relative to the global minimum (above 4 kJ mol-1 at both low and ambient temperatures) suggesting a more stable polymorph is likely not yet observed. The calculation of free energies at ambient temperatures offered improvement of predictions only in some cases (for targets XXVII and XXXI). Several avenues for future research have been suggested, highlighting the need for greater efficiency considering the vast amounts of resources utilized in many cases

Natural vibration analysis of tensioned risers by segmentation method

The natural vibration of deepwater tensioned uniform risers is analysed. The riser is considered as both a cable and a beam due to the fairly weak flexural stiffness. The exact and asymptotic solutions of the cable differential equation are presented. The beam vibration is determined by modifying the cable solution for each halfwave of the natural mode which are called segments . The simplified analytical procedure is verified by the finite element method. Very valuable conclusions are drawn on riser dynamic behaviour in the lower and higher frequency domain. The main application of the study is the assessment of forced vortexinduced riser vibration

Development of a virtual reality simulatorreplacing the check valve on christmas tree

The article describes the stages of the process of creating a virtual reality simulator using the example of a standard operating procedure for replacing a check valve on a Christmas tree. A brief overview of the Christmas tree arrangement and an analysis of the stages of the check valve replacement are described. A short algorithm has been developed based on 11 out of 16 implemented stages. The choice of hardware platform and software is substantiated. Using the Christmas tree as an example, the processes of creating a three-dimensional model and unfolding textures in the three-dimensional editor 3ds Max, creating color maps, reflection and texture normals in the graphical editor Substance Painter are described. The process of creating a landscape in the Unity3D environment is described. Oculus Integration and VR TK assets were used in the development of the main scripts.</jats:p

Is temporomandibular disfunction an occupational disease of flautists?

Wind instrumentalists are prone to a number of occupational hazards that can lead to occupational diseases. C. Zaza defined these diseases as playing-related musculoskeletal disorders (PRMD). Such occupational diseases are devastating for musicians in terms of psychological health and financial state.&#x0D; According to various epidemiological studies, 6286% of orchestra musicians experienced PRMD. Particularly the pressure of the mouthpiece on the lower incisors of wind instrumentalists leads to their movement and provoke periodontal diseases. Moreover, wind instrumentalists place themselves at risk of allergies and galvanism. Musicians do not seek for dental help due to the fear of spoiled embouchure (habitual position of the cheeks, tongue, and lips while playing) in spite of the range of specific oral pathologies. Flautists are of particular interest to dental practitioners because they are subjected to several risk factors; in addition to the mouthpiece pressure, they often hold instruments in an asymmetric posture, and in constrained spaces, being surrounded by the other orchestra musicians.&#x0D; To learn more about the occupational hazards of flautists, we searched for the relevant literature in the central research medical library and for articles in databases eLIBRARY, PubMed, and ResearchGate using the following keywords: wind instrumentalists, flute, temporomandibular disorders, and playing-related musculoskeletal disorders.&#x0D; Some studies claim that the asymmetric posture of flautist, especially in cramped conditions, affects the musicians health and leads to PRMD. Nevertheless, this research topic has been neglected, and published studies lack a strong methodology, explaining why they fail to show a strong association between TMD and flute playing. Therefore, further research is needed.</jats:p

Method for appendix stump closure during laparoscopic appendectomy (literature review)

Currently, the laparoscopic appendectomy is the preferred method for treatment of acute appendicitis. Laparoscopic approach resulted in a decrease of postoperative morbidity (especially for reducing the frequency of surgical site infection), allows to faster postoperative recovery of patients. The method of closure of the appendix stump is the main step of laparoscopic appendectomy. The risk of intra-abdominal complications is considered high during this step. Therefore, it is important to choose the safest method of closure of the appendix stump among the number of available options. The four prominent management options are endoloops, staplers, endoclips and inversion of appendix stump with intracorporal sutures. This literature review presents the advantages and disadvantages of these methods. The results of randomized studies and meta-analysis comparing the methods are also presented. It is shown that there is no evidence pointing to any of the existing methods to be a safer option. It is suggested that factors such as anatomy features, cost efficiency and personal experience of the surgeon using these methods are considered to determine the choice.</jats:p

Development of a new metal alloy based on palladium within the framework of practical implementation of the concept of development of the domestic dental materials science

The article shows the creation of the new Russian alloy based on palladium for metal-ceramic dental prostheses "Palladini UNI puteam comprehensive analysis of the influence of alloying elements on the phase structure of the palladium alloys, physical and mechanical properties and coefficient of thermal linear expansion.</jats:p