Physicochemical Analysis and Molecular Modeling of the Fosinopril β

This research investigates the interaction between fosinopril sodium (FOS) and beta-cyclodextrin (β-CD) in aqueous solution and in solid state, in order to prove the formation of an inclusion complex between the two components. The stoichiometry of the inclusion complex was found as 1 : 1 by employing continuous variation method in UV. The formation constant was calculated as 278.93 M−1 using Benesi-Hildebrand equation. The kneaded product (KP) and the physical mixture (PM) were further experimentally examined, using FTIR, powder X-ray diffractometry, and thermal analysis. The results confirm that the physicochemical properties of the FOS/β-CD KP are different from FOS and that the kneading method leads to formation of solid state inclusion complex between FOS and β-CD. Structural studies of the FOS/β-CD were carried out using molecular modeling techniques, in order to explain the complexation mechanism and the host-guest geometry

Effect of different swelling agents on textural and structural properties of modified mesoporous silica

In this study was carried out the preparation of some large-pore ordered mesoporous silicas using a proper surfactant with different swelling agents. In order to use a micelle swelling agent with a moderate swelling ability we selected three swelling agents: 1-phenyldecane, butyl benzene and mesitylene. The aim of these synthesis was to achieve a pore diameter enlargement but in the same time to avoid the formation of heterogeneous and/or poorly defined nanostructure of silica. These composites were characterized by FT-IR spectroscopy, X-ray diffraction at low angles, nitrogen physisorption at 77 K, SEM-EDS. In the view of a possible use of these amino-functionalized mesoporous silicas as adsorbents for CO2 removal, their adsorption– desorption properties towards CO2 were investigated by the TPD method. CO2 adsorption isotherms of amino-functionalized mesoporous silicas measured at 50, 60 and 70 °C showed that the adsorption capacity (mg CO2/g adsorbent) depend on the temperature of adsorption and on the type of swelling agents and amination reagents used