New Proposal to Iran: Will It Be Enough to Defuse the Nuclear Crisis?

This BASIC Note assesses the progress of transatlantic diplomacy toward Iran on nuclear issues. On June 6, Iran was presented with a revised package of incentives to persuade it to curb its uranium enrichment program. The authors argued previously that the earlier E3/EU proposal was vague on incentives and heavy on demands. (See BASIC Note, August 11, 2005 at http://www.basicint.org/pubs/Notes/BN050811-IranEU.htm). In this article, the authors suggest that if the June 6 proposal had been offered a year ago (or better still two years ago), much of the recent damage to diplomatic relations between Iran and the West could have been avoided

Spanning the Institutional Abyss: The Intergovernmental Network and the Governance of Foreign Direct Investment

Global economic transactions such as foreign direct investment must extend over an institutional abyss between the jurisdiction, and therefore protection, of the states involved. Intergovernmental organizations (IGOs), whose members are states, represent an important attempt to span this abyss. IGOs are mandated variously to smooth economic transactions, facilitate global cooperation, and promote cultural contact and awareness. We use a network approach to demonstrate that the connections between two countries through joint-membership in the same IGOs are associated with a large positive influence on the foreign direct investment that flows between them. Moreover, we show that this effect occurs not only in the case of IGOs that focus on economic issues, but also on those with social and cultural mandates. This demonstrates that relational governance is important and feasible in the global context, and for the most risky transactions. Finally we examine the interdependence between the IGO network and the domestic institutions of states. The interdependence between these global and domestic institutional forms is complex, with target-country democracy being a substitute for economic IGOs, but a complement for social and cultural IGOs.

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers

COMPETITIVE GRANTS AND THE FUNDING OF AGRICULTURAL RESEARCH IN THE U.S.

To increase the efficiency of the public agricultural R&D system, expanded use of competitive grants to fund state institutions has been advocated. This paper characterizes different funding instruments and empirically assesses the effects of changes in mechanism use. Factors associated with greater levels of competitive grants are modeled.Research and Development/Tech Change/Emerging Technologies,

Three clean products from co-mingled waste using a novel hydrodynamic separator

Mixed municipal solid waste currently landfilled contains a high percentage of packaging glass, varying from 33% to 80% by weight according to several sample characterizations, due to the lack of high throughput separation technology. The hydrodynamic separator proposed is a closed-loop device developed to separate co-mingled waste into plastics, glass and other dense particles and organic sludge. The glass and other dense material stream is cleaned by the system, permitting efficient downstream optical sorting to take out metals and ceramics and, if required, glass sorted by colour. The plastics and the organic sludge are separate, processable waste streams. As the solid waste is introduced in the separator, the action of water jets located on the ramps of a fixed sinusoidal-shape bottom and the presence of hydrofoils at the upper part of the tank produce a flow pattern that lead plastics towards its collection point on the surface, while glass and ceramics are settled to the bottom of the tank and transported to the extraction point. Organics and other fine particles are obtained from lamellas, before reintroducing the clarified fluid into the flow loop. The sludge obtained from this process is suitable for feedstock to Anaerobic Digestion processes. In the present paper the equipment and the methodology is described and the physical principles of the separation process are explained. Results from a full scale trial designed to process 9.7 tonnes per hour at a municipal UK waste site operating in Nov 2015 – Feb 2016 are presented

Early evidence of bone marrow dysfunction in children with indeterminate fulminant hepatic failure who ultimately develop aplastic anemia.

In children, aplastic anemia (AA) is a common complication associated with fulminant hepatic failure (FHF). The objective of this study was to determine whether specific pretransplantation clinical and laboratory characteristics can be used to distinguish between patients with FHF who are at higher risk of developing AA. We performed a retrospective case-control study to evaluate the clinical and laboratory characteristics of those patients who presented with evidence of FHF and eventually developed aplastic anemia. We identified nine patients with AA, and all had the indeterminate form of FHF and underwent liver transplantation (LTx). The AA patients were compared with a control group of 47 patients with indeterminate FHF that underwent transplantation and did not develop AA. We found that males were over-represented in the group of patients that developed AA (p = 0.01). Furthermore, during the pretransplant period, the AA group had a significantly lower white count (p = 0.005), absolute lymphocyte count (p = 0.004), and platelet count (p = 0.019) when compared with controls. We conclude that evidence of early bone marrow dysfunction is apparent before liver transplantation and the development of AA in a subset of patients with the indeterminate form of FHF

Testing general relativity with accretion onto compact objects

The X-ray emission of neutron stars and black holes presents a rich phenomenology that can lead us to a better understanding of their nature and to address more general physics questions: Does general relativity apply in the strong gravity regime? Is spacetime around black holes described by the Kerr metric? This white paper considers how we can investigate these questions by studying reverberation mapping and quasi-periodic oscillations in accreting systems with a combination of high-spectral and high-timing resolution. In the near future, we will be able to study compact objects in the X-rays in a new way: advancements in transition-edge sensors (TES) technology will allow for electron-volt-resolution spectroscopy combined with nanoseconds-precision timing.Comment: White paper submitted for Astro2020 Decadal Survey. 8 pages, 2 figure