From Goethe to Gundolf

"From Goethe to Gundolf: Essays on German Literature and Culture is a collection of Roger Paulin’s groundbreaking essays, spanning the last forty years. The work represents his major research interests of Romanticism and the reception of Shakespeare in Germany, but also explores a broader range of themes, from poetry and the public memorialization of poets to fairy stories - all meticulously researched, yet highly accessible. As a comprehensive examination of German literary history in the period 1700-1900, the collection not only includes accounts of the lives and work of Goethe, Schiller, the Schlegels, and Gundolf (amongst others), serving to nuance our understanding of these figures in history, but also considers diverse (and often underexplored) topics, from academic freedom to the rise of travel literature. The essays have been reformulated, corrected, and updated to add references to recent works. However, the core foundations of the originals remain, and just as when they were first published, the value of these essays – to researchers, students, and all those who are interested in German literary history – cannot be overstated.

Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.

IntroductionPopulation-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air pollutants on patient-reported outcomes, morbidity and progression of COPD.Methods and analysisThe Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Pollution Study (SPIROMICS AIR) was initiated in 2013 to investigate the relation between individual-level estimates of short-term and long-term air pollution exposures, day-to-day symptom variability and disease progression in individuals with COPD. SPIROMICS AIR builds on a multicentre study of smokers with COPD, supplementing it with state-of-the-art air pollution exposure assessments of fine particulate matter, oxides of nitrogen, ozone, sulfur dioxide and black carbon. In the parent study, approximately 3000 smokers with and without airflow obstruction are being followed for up to 3 years for the identification of intermediate biomarkers which predict disease progression. Subcohorts undergo daily symptom monitoring using comprehensive daily diaries. The air monitoring and modelling methods employed in SPIROMICS AIR will provide estimates of individual exposure that incorporate residence-specific infiltration characteristics and participant-specific time-activity patterns. The overarching study aim is to understand the health effects of short-term and long-term exposures to air pollution on COPD morbidity, including exacerbation risk, patient-reported outcomes and disease progression.Ethics and disseminationThe institutional review boards of all the participating institutions approved the study protocols. The results of the trial will be presented at national and international meetings and published in peer-reviewed journals

Die Ähnlichkeit der Götter: Ein Billet Alexander von Humboldts an August Wilhelm Schlegel in der SLUB Dresden

Roger Paulin, einer der besten Kenner der europäischen Literatur des 18. Jahrhunderts, bereitet die erste neuere Biographie zu August Wilhelm Schlegel vor. Die Grundlage dafür ist der Nachlass Schlegels, der sich im Bestand der Handschriftenabteilung der SLUB Dresden befindet

Maria Stuart

"Maria Stuart, described as Schiller’s most perfect play, is a finely balanced, inventive account of the last day of the captive Queen of Scotland, caught up in a great contest for the throne of England after the death of Henry VIII and over the question of England’s religious confession. Hope for and doubt about Mary’s deliverance grow in the first two acts, given to the Scottish and the English queen respectively, reach crisis at the center of the play, where the two queens meet in a famous scene in a castle park, and die away in acts four and five, as the action advances to its inevitable end. The play is at once classical tragedy of great fineness, costume drama of the highest order—a spectacle on the stage—and one of the great moments in the long tradition of classical rhetoric, as Elizabeth’s ministers argue for and against execution of a royal prisoner. Flora Kimmich’s new translation carefully preserves the spirit of the original: the pathos and passion of Mary in captivity, the high seriousness of Elizabeth’s ministers in council, and the robust comedy of that queen’s untidy private life. Notes to the text identify the many historical figures who appear in the text, describe the political setting of the action, and draw attention to the structure of the play. Roger Paulin’s introduction discusses the many threads of the conflict in Maria Stuart and enriches our understanding of this much-loved, much-produced play. Maria Stuart is the last of a series of five new translations of Schiller’s major plays, accompanied by notes to the text and an authoritative introduction.

Morphological and molecular characterization of a new mycobacterium avium Subsp. paratuberculosis S-type strain Genotype in goats

Paratuberculosis is a chronic bacterial disease of global importance mainly in domestic and wild ruminants, caused by Mycobacterium avium subsp. paratuberculosis (MAP). In goats, paratuberculosis is mostly caused by the "C-type" (cattle) and in a few cases by the "S-type" (sheep) strain of MAP. In 2017, a caprine S-type III isolate with a new VNTR profile was identified in a Swiss alpine region. In 2018, new caprine isolates with the same novel VNTR profile originating from a farm of a close by neighboring valley were analyzed. Here we report on this MAP S-type III outbreak in a Swiss dairy goat farm in which we investigated the pathological changes, distribution and genotype of MAP tissue homogenates. Full necropsy and histological examination were undertaken on two female adult goats with a history of weight loss and intermitting diarrhea. Routine and special stains were applied to characterize the morphological changes. DNA was extracted from 33 different tissue samples and tested for MAP by qPCR targeting IS900 and F57. Subtyping was performed, using the variable number tandem repeats (VNTR) and mycobacterial interspersed repetitive units (MIRU) approach. The goats showed moderate to marked emaciation and displayed typical clinical features of paratuberculosis. A moderate granulomatous enteritis and regional lymphadenitis with a small to moderate number of acid-fast bacteria within macrophages was detected. MAP detection was mainly restricted to the gastrointestinal tract, mesenteric and hepatic lymph nodes. Subtyping the S-type isolates using a panel of eight established MIRU-VNTR loci identified a new genotype, INMV 218

Introduction: building the history of language learning and teaching (HoLLT)

The papers presented in this issue are the result of a workshop held at the University of Nottingham in December 2012 as part of an Arts and Humanities Research Council research network Towards a History of Modern Foreign Language Teaching and Learning (2012–14) intended to stimulate historical research into language teaching and learning. This, the first workshop in the programme, focused on exchanging information on the history of language learning and teaching (HoLLT) across the different language traditions, for it had become clear to us that scholars working within their own language disciplines were often relatively unaware of work outside these. We hope that this special issue — with overview articles on the history of English, French, German, and Spanish as second/foreign languages — will help overcome that lack of awareness and facilitate further research collaboration. Charting the history of language teaching and learning will, in turn, make us all better informed in facing challenges and changes to policy and practice now and in the future. It is instructive in the current climate, for example, to realize that grave doubts were held about whether second foreign languages could survive alongside French in British schools in the early twentieth century (McLelland, forthcoming), or to look back at earlier attempts to establish foreign languages in primary schools (Bayley, 1989; Burstall et al., 1974; Hoy, 1977). As we write, language learning in England is undergoing yet more radical change. Language teaching for all children from the age of seven is being made compulsory in primary schools from 2014, while at Key Stage 3 (up to age 16), where a foreign language has not been compulsory since 2002, the most recent programme of study for England has virtually abandoned the recent focus on intercultural competence and now requires learners to ‘read great literature in the original language’,1 a radical change in emphasis compared to the previous half-century, which seems to reflect a very different view of what language learning is for. We seem to be little closer in 2014 than we were at the dawn of the twentieth century to answering with any certainty the questions that lie at the very foundations of language teaching: who should learn a foreign language, why learners learn, what they need to learn, and what we want to teach them — answers that we need before we can consider how we want to teach. The research programme begun under our research network is intended to help us to take ‘the long view’ on such questions

Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures

While neurosurgical interventions are frequently used in laboratory mice, refinement efforts to optimize analgesic management based on multimodal approaches appear to be rather limited. Therefore, we compared the efficacy and tolerability of combinations of the non-steroidal anti-inflammatory drug carprofen, a sustained-release formulation of the opioid buprenorphine, and the local anesthetic bupivacaine with carprofen monotherapy. Female and male C57BL/6J mice were subjected to isoflurane anesthesia and an intracranial electrode implant procedure. Given the multidimensional nature of postsurgical pain and distress, various physiological, behavioral, and biochemical parameters were applied for their assessment. The analysis revealed alterations in Neuro scores, home cage locomotion, body weight, nest building, mouse grimace scales, and fecal corticosterone metabolites. A composite measure scheme allowed the allocation of individual mice to severity classes. The comparison between groups failed to indicate the superiority of multimodal regimens over high-dose NSAID monotherapy. In conclusion, our findings confirmed the informative value of various parameters for assessment of pain and distress following neurosurgical procedures in mice. While all drug regimens were well tolerated in control mice, our data suggest that the total drug load should be carefully considered for perioperative management. Future studies would be of interest to assess potential synergies of drug combinations with lower doses of carprofen

ANALYSE DES DEPENSES PUBLIQUES ET DES MENAGES EN SANTE EN RDCONGO, CAS DU PROGRAMME NATIONAL DES COMPTES NATIONAUX DE SANTE DE 2018 A 2022

Il a été question dans cette étude, d’analyser les dépenses publiques et des ménages en santé en RDC de 2018 à 2022. La méthodologie utilisée est celle du Système des Comptes de la Santé (SHA 2011), basée sur une nomenclature et une classification internationale fine et détaillée de la dépense de santé. Les résultats    obtenues en analysant le rapport des comptes de santé en RDC stipule que les principales sources de financement sont : le Gouvernement, les bailleurs de fonds (coopérations bi et multilatérales, ONGs nationales et internationales, Fondations et initiatives internationales), les ménages /populations, les Entreprises publiques et privées.   Les dépenses totales de santé augmentent chaque année. Entre 2018 et 2022, elles sont passées de 1 585 959 993 USD à 2 520 381 562 USD, soit une augmentation de 36,8 %. Par ailleurs, la proportion entre DCS et DIS est restée quasiment constante sur la période (+95% pour les DCS et -5% pour les DIS). Ces dépenses sont restées constantes tout au long de la période sous revue en % du PIB (4% en moyenne).   Les ménages restent la première source de financement (40% de la DCS en 2022). Son financement est passé de 705 921 834 USD à 1 005 925 107 USD entre 2018 et 2022, soit une augmentation de 29,8%